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Photoallergic responses to chemicals

Journal Article:

Abstract

Photochemical and immunologic knowledge about photoallergy to chemicals is briefly summarized. Studies in in vitro systems have demonstrated that photoallergic compounds can covalently bond to proteins through a photochemical reaction. The immunologic nature of the photoallergic response is based mainly on clinical observations, induction of photoallergy in man and in guinea-pigs and on results of in vitro immunologic tests. Studies of the photoreactions of the photoallergic compound, 3,3',4',5-tetrachlorosalicylanilide (TCSA) with proteins are discussed. TSCA noncovalently bonds to human serum albumin prior to irradiation. Prior interaction is essential for formation of a photoaddition product indicating that a short-lived reactive species derived from TCSA is involved in the photoaddition and limiting the number of skin proteins which can participate in antigen formation. By fragmentation of the TCSA-albumin photoadduct with CNBr, it was determined that TCSA can bond to at least three sites on the albumin molecule. TCSA alone can sensitize the photooxidation of histidine in albumin.
Authors:
Kochievar, I E [1] 
  1. Columbia Univ., New York (USA). Coll. of Physicians and Surgeons
Publication Date:
Oct 01, 1979
Product Type:
Journal Article
Reference Number:
AIX-11-499550; EDB-80-057767
Resource Relation:
Journal Name: Photochem. Photobiol.; (United Kingdom); Journal Volume: 30:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ALLERGY; IMMUNE REACTIONS; PHOTOCHEMISTRY; ADDUCTS; ALBUMINS; ANILINE; ANTIGENS; BLOOD SERUM; CHEMICAL BONDS; COVALENCE; HISTIDINE; MOLECULAR STRUCTURE; ORGANIC CHLORINE COMPOUNDS; OXIDATION; PHOTOSENSITIVITY; SALICYLIC ACID; SKIN; AMINES; AMINO ACIDS; AROMATICS; AZOLES; BODY; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; CHEMISTRY; DISEASES; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; HYDROXY ACIDS; IMIDAZOLES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PROTEINS; SENSITIVITY; 560121* - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
5408788
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: PHCBA
Submitting Site:
INIS
Size:
Pages: 437-442
Announcement Date:
Mar 01, 1980

Journal Article:

Citation Formats

Kochievar, I E. Photoallergic responses to chemicals. United Kingdom: N. p., 1979. Web.
Kochievar, I E. Photoallergic responses to chemicals. United Kingdom.
Kochievar, I E. 1979. "Photoallergic responses to chemicals." United Kingdom.
@misc{etde_5408788,
title = {Photoallergic responses to chemicals}
author = {Kochievar, I E}
abstractNote = {Photochemical and immunologic knowledge about photoallergy to chemicals is briefly summarized. Studies in in vitro systems have demonstrated that photoallergic compounds can covalently bond to proteins through a photochemical reaction. The immunologic nature of the photoallergic response is based mainly on clinical observations, induction of photoallergy in man and in guinea-pigs and on results of in vitro immunologic tests. Studies of the photoreactions of the photoallergic compound, 3,3',4',5-tetrachlorosalicylanilide (TCSA) with proteins are discussed. TSCA noncovalently bonds to human serum albumin prior to irradiation. Prior interaction is essential for formation of a photoaddition product indicating that a short-lived reactive species derived from TCSA is involved in the photoaddition and limiting the number of skin proteins which can participate in antigen formation. By fragmentation of the TCSA-albumin photoadduct with CNBr, it was determined that TCSA can bond to at least three sites on the albumin molecule. TCSA alone can sensitize the photooxidation of histidine in albumin.}
journal = {Photochem. Photobiol.; (United Kingdom)}
volume = {30:4}
journal type = {AC}
place = {United Kingdom}
year = {1979}
month = {Oct}
}