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Radiation sensitivity of messenger RNA

Journal Article:

Abstract

Messenger RNA function is inactivated by irradiation with ultraviolet light. A unit length mRNA (in bases) is 2-3 times more sensitive than a unit length of DNA (in base pairs) with respect to the inactivation of template function. These data stem from four experimental systems all of which do not repair DNA: the translation of E. coli mRNA in rifampicin-treated cells, of T7 mRNA in infected E.coli, of f2 phage RNA in vivo, and of stable mRNA in chromosomeless minicells. The comparison of relative sensitivities to UV is relevant to the technique of UV mapping of transcription units which enjoys increasing popularity in pro- and eukaryotic genetic research.
Authors:
Ponta, H; Pfennig-Yeh, M L; Herrlich, P; [1]  Karlsruhe Univ. (TH) (Germany, F.R.). Inst. fuer Genetik); Wagner, E F; Schweiger, M [2] 
  1. Kernforschungszentrum Karlsruhe G.m.b.H. (Germany, F.R.). Inst. fuer Genetik und Toxikologie von Spaltstoffen
  2. Innsbruck Univ. (Austria). Inst. fuer Biochemie
Publication Date:
Aug 01, 1979
Product Type:
Journal Article
Reference Number:
AIX-11-499557; EDB-80-057784
Resource Relation:
Journal Name: Mol. Gen. Genet.; (Germany, Federal Republic of); Journal Volume: 175:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MESSENGER-RNA; RADIOSENSITIVITY; BIOLOGICAL REPAIR; COMPARATIVE EVALUATIONS; ESCHERICHIA COLI; GENETIC RADIATION EFFECTS; IN VIVO; ULTRAVIOLET RADIATION; BACTERIA; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; ELECTROMAGNETIC RADIATION; GENETIC EFFECTS; MICROORGANISMS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RECOVERY; REPAIR; RNA; 560131* - Radiation Effects on Microorganisms- Basic Studies- (-1987)
OSTI ID:
5408638
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: MGGEA
Submitting Site:
INIS
Size:
Pages: 13-17
Announcement Date:

Journal Article:

Citation Formats

Ponta, H, Pfennig-Yeh, M L, Herrlich, P, Karlsruhe Univ. (TH) (Germany, F.R.). Inst. fuer Genetik), Wagner, E F, and Schweiger, M. Radiation sensitivity of messenger RNA. Germany: N. p., 1979. Web.
Ponta, H, Pfennig-Yeh, M L, Herrlich, P, Karlsruhe Univ. (TH) (Germany, F.R.). Inst. fuer Genetik), Wagner, E F, & Schweiger, M. Radiation sensitivity of messenger RNA. Germany.
Ponta, H, Pfennig-Yeh, M L, Herrlich, P, Karlsruhe Univ. (TH) (Germany, F.R.). Inst. fuer Genetik), Wagner, E F, and Schweiger, M. 1979. "Radiation sensitivity of messenger RNA." Germany.
@misc{etde_5408638,
title = {Radiation sensitivity of messenger RNA}
author = {Ponta, H, Pfennig-Yeh, M L, Herrlich, P, Karlsruhe Univ. (TH) (Germany, F.R.). Inst. fuer Genetik), Wagner, E F, and Schweiger, M}
abstractNote = {Messenger RNA function is inactivated by irradiation with ultraviolet light. A unit length mRNA (in bases) is 2-3 times more sensitive than a unit length of DNA (in base pairs) with respect to the inactivation of template function. These data stem from four experimental systems all of which do not repair DNA: the translation of E. coli mRNA in rifampicin-treated cells, of T7 mRNA in infected E.coli, of f2 phage RNA in vivo, and of stable mRNA in chromosomeless minicells. The comparison of relative sensitivities to UV is relevant to the technique of UV mapping of transcription units which enjoys increasing popularity in pro- and eukaryotic genetic research.}
journal = {Mol. Gen. Genet.; (Germany, Federal Republic of)}
volume = {175:1}
journal type = {AC}
place = {Germany}
year = {1979}
month = {Aug}
}