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ACTHsub(1-24) and lysine vasopressin selectively activate dopamine synthesis in frontal cortex

Journal Article:

Abstract

The accumulation of (/sup 3/H)catecholamines from (/sup 3/H)tyrosine in frontal cortical, septal, striatal and hippocampal slices was examined following intracerebroventricular (i.c.v.) injections of ACTHsub(1-24), lysine vasopressin (LVP) and saline. Both ACTHsub(1-24) and LVP (1..mu..g) selectively increased the accumulation of (/sup 3/H)dopamine (DA) in frontal cortical slices, but did not affect that of (/sup 3/H)norepinephrine (NE). LVP but not ACTHsub(1-24) also inhibited the accumulation of (/sup 3/H)DA in striatal slices. ACTHsub(1-24) did not alter the accumulation of (/sup 3/H)NE in hippocampal slices, nor did LVP alter the accumulation of either catecholamine (CA) in septal slices. In vitro incubations with ACTH analogs or LVP failed to alter the rate of accumulation of (/sup 3/H)CAs in striatal, substantia nigral and frontal cortical slices, except for an inhibitory effect at high doses. This effect is believed to be an artifact of precursor dilution caused by release of tyrosine following degradation of the peptides. Neither peptide modified the increased (/sup 3/H)CA accumulation stimulated by 26 mM K/sup +/, nor did ACTHsub(1-24) modify the inhibition of (/sup 3/H)CA accumulation caused by 3 X 10/sup -6/ M Haloperidol or 3 X 10/sup -7/ M apomorphine. Selective activation of the mesocortical DA system has also been reported to  More>>
Authors:
Delanoy, R L; Kramarcy, N R; Dunn, A J [1] 
  1. Florida Univ., Gainesville (USA). Coll. of Medicine
Publication Date:
Jan 07, 1982
Product Type:
Journal Article
Reference Number:
AIX-13-671406; EDB-82-104935
Resource Relation:
Journal Name: Brain Res.; (Netherlands); Journal Volume: 231:1
Subject:
59 BASIC BIOLOGICAL SCIENCES; CATECHOLAMINES; BUILDUP; CEREBRAL CORTEX; TYROSINE; DOPAMINE; LABELLED COMPOUNDS; LYSINE; MICE; RADIONUCLIDE KINETICS; TRITIUM; VASOPRESSIN; AMINES; AMINO ACIDS; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; BRAIN; CARBOXYLIC ACIDS; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; CEREBRUM; DRUGS; HORMONES; HYDROGEN ISOTOPES; HYDROXY ACIDS; HYDROXY COMPOUNDS; ISOTOPES; LIGHT NUCLEI; MAMMALS; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PHENOLS; PITUITARY HORMONES; POLYPHENOLS; RADIOISOTOPES; RODENTS; SYMPATHOMIMETICS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 550501* - Metabolism- Tracer Techniques
OSTI ID:
5405457
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BRREA
Submitting Site:
HEDB
Size:
Pages: 117-129
Announcement Date:

Journal Article:

Citation Formats

Delanoy, R L, Kramarcy, N R, and Dunn, A J. ACTHsub(1-24) and lysine vasopressin selectively activate dopamine synthesis in frontal cortex. Netherlands: N. p., 1982. Web.
Delanoy, R L, Kramarcy, N R, & Dunn, A J. ACTHsub(1-24) and lysine vasopressin selectively activate dopamine synthesis in frontal cortex. Netherlands.
Delanoy, R L, Kramarcy, N R, and Dunn, A J. 1982. "ACTHsub(1-24) and lysine vasopressin selectively activate dopamine synthesis in frontal cortex." Netherlands.
@misc{etde_5405457,
title = {ACTHsub(1-24) and lysine vasopressin selectively activate dopamine synthesis in frontal cortex}
author = {Delanoy, R L, Kramarcy, N R, and Dunn, A J}
abstractNote = {The accumulation of (/sup 3/H)catecholamines from (/sup 3/H)tyrosine in frontal cortical, septal, striatal and hippocampal slices was examined following intracerebroventricular (i.c.v.) injections of ACTHsub(1-24), lysine vasopressin (LVP) and saline. Both ACTHsub(1-24) and LVP (1..mu..g) selectively increased the accumulation of (/sup 3/H)dopamine (DA) in frontal cortical slices, but did not affect that of (/sup 3/H)norepinephrine (NE). LVP but not ACTHsub(1-24) also inhibited the accumulation of (/sup 3/H)DA in striatal slices. ACTHsub(1-24) did not alter the accumulation of (/sup 3/H)NE in hippocampal slices, nor did LVP alter the accumulation of either catecholamine (CA) in septal slices. In vitro incubations with ACTH analogs or LVP failed to alter the rate of accumulation of (/sup 3/H)CAs in striatal, substantia nigral and frontal cortical slices, except for an inhibitory effect at high doses. This effect is believed to be an artifact of precursor dilution caused by release of tyrosine following degradation of the peptides. Neither peptide modified the increased (/sup 3/H)CA accumulation stimulated by 26 mM K/sup +/, nor did ACTHsub(1-24) modify the inhibition of (/sup 3/H)CA accumulation caused by 3 X 10/sup -6/ M Haloperidol or 3 X 10/sup -7/ M apomorphine. Selective activation of the mesocortical DA system has also been reported to occur in response to footshock, suggesting the possibility that endogenous ACTH and/or LVP might mediate the stress-induced activation of mesocortical DA synthesis. Alternatively, i.c.v. injections of these peptides may themselves be stressful and thus indirectly elicit the response.}
journal = {Brain Res.; (Netherlands)}
volume = {231:1}
journal type = {AC}
place = {Netherlands}
year = {1982}
month = {Jan}
}