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Spontaneous and x-irradiation induced carcinomas of small intestine in Wistar-Furth rats

Journal Article:

Abstract

Spontaneous carcinoma of the small intestine in Wistar-Furth (WF) rats and carcinoma of the small intestine induced by local x-ray irradiation to the abdomen of WF rats without carcinoma were observed, and x-ray sensitivity of the small intestine mucosa was reported. Out of 19 rats with spontaneous carcinoma of the small intestine, 18 also had carcinoma of the colon, and 4 also had gastric cancer. They already had spontaneous carcinoma of the small intestine within 2 weeks after their birth, and the ratio of female and male was 13 : 6. Histological type of this carcinoma in all 19 rats was highly differentiated adenocarcinoma, and small intestine epithelium around carcinoma presented atypical epithelium. As to mice without carcinoma, x-ray, 1,000 R, 1,500 R, and 2,000 R, was irradiated to the abdomen of Sprague-Dawley (SD) and WF rats. In the irradiation with 1,000 R, carcinogenesis was not found in rats of both strains. In the irradiation with 1,500 R, carcinogenesis was hardly found, but in the irradiation with 2,000 R, carcinoma of small intestine occurred in 5 of 17 rats 15 weeks after the irradiation, 9 of 19 rats 25 weeks after the irradiation, and 9 of 14 rats 35 weeks  More>>
Authors:
Maeura, Y; Kosaki, G; Kitamura, H; [1]  Nagatomo, T
  1. Osaka Univ. (Japan). Faculty of Medicine
Publication Date:
Apr 01, 1980
Product Type:
Journal Article
Reference Number:
AIX-13-674796; EDB-82-116229
Resource Relation:
Journal Name: Igaku No Ayumi; (Japan); Journal Volume: 113:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; SMALL INTESTINE; BIOLOGICAL RADIATION EFFECTS; X RADIATION; CARCINOGENESIS; AGE DEPENDENCE; CARCINOMAS; COMPARATIVE EVALUATIONS; LARGE INTESTINE; RADIATION DOSES; RATS; SPECIFICITY; STOMACH; ANIMALS; BIOLOGICAL EFFECTS; BODY; DIGESTIVE SYSTEM; DISEASES; DOSES; ELECTROMAGNETIC RADIATION; GASTROINTESTINAL TRACT; INTESTINES; IONIZING RADIATIONS; MAMMALS; NEOPLASMS; ORGANS; PATHOGENESIS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
5403390
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: IGAYA
Submitting Site:
HEDB
Size:
Pages: 175-177
Announcement Date:

Journal Article:

Citation Formats

Maeura, Y, Kosaki, G, Kitamura, H, and Nagatomo, T. Spontaneous and x-irradiation induced carcinomas of small intestine in Wistar-Furth rats. Japan: N. p., 1980. Web.
Maeura, Y, Kosaki, G, Kitamura, H, & Nagatomo, T. Spontaneous and x-irradiation induced carcinomas of small intestine in Wistar-Furth rats. Japan.
Maeura, Y, Kosaki, G, Kitamura, H, and Nagatomo, T. 1980. "Spontaneous and x-irradiation induced carcinomas of small intestine in Wistar-Furth rats." Japan.
@misc{etde_5403390,
title = {Spontaneous and x-irradiation induced carcinomas of small intestine in Wistar-Furth rats}
author = {Maeura, Y, Kosaki, G, Kitamura, H, and Nagatomo, T}
abstractNote = {Spontaneous carcinoma of the small intestine in Wistar-Furth (WF) rats and carcinoma of the small intestine induced by local x-ray irradiation to the abdomen of WF rats without carcinoma were observed, and x-ray sensitivity of the small intestine mucosa was reported. Out of 19 rats with spontaneous carcinoma of the small intestine, 18 also had carcinoma of the colon, and 4 also had gastric cancer. They already had spontaneous carcinoma of the small intestine within 2 weeks after their birth, and the ratio of female and male was 13 : 6. Histological type of this carcinoma in all 19 rats was highly differentiated adenocarcinoma, and small intestine epithelium around carcinoma presented atypical epithelium. As to mice without carcinoma, x-ray, 1,000 R, 1,500 R, and 2,000 R, was irradiated to the abdomen of Sprague-Dawley (SD) and WF rats. In the irradiation with 1,000 R, carcinogenesis was not found in rats of both strains. In the irradiation with 1,500 R, carcinogenesis was hardly found, but in the irradiation with 2,000 R, carcinoma of small intestine occurred in 5 of 17 rats 15 weeks after the irradiation, 9 of 19 rats 25 weeks after the irradiation, and 9 of 14 rats 35 weeks after the irradiation. Histological type of carcinoma in irradiated rats was highly differentiated adenocarcinoma. The incidence of carcinoma in irradiated rats was higher in WF rats than SD rats through the course after the irradiation, which suggested that x-ray sensitivity of WF rats was higher than that of SD rats. Therefore, carcinoma of the small intestine in irradiated mice seemed to be induced by x-ray.}
journal = {Igaku No Ayumi; (Japan)}
volume = {113:3}
journal type = {AC}
place = {Japan}
year = {1980}
month = {Apr}
}