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/sup 35/S induced dominant lethals in immature oocytes in mice

Journal Article:

Abstract

CBA female mice were injected intraperitoneally with a dose of 20..mu..Ci of sulphur-35 on 15.5 day post conception. Another group of pregnant mice injected with normal saline was kept as control. The pregnant females were allowed to litter and the mothers were separated from their offsprings 4 weeks after littering. Eight weeks after treatment i.e. at the age of 22 to 24 weeks, the treated mothers were mated with control C/sub 3/H/He males. The vaginal plugs were checked every morning and those which mated were separated. The pregnant females were killed on the 14th day of gestation. The uterine contents were examined for live and dead embryos and the ovaries for corpora lutea. The pre- and post-implantation losses and total loss were calculated in the treated females and compared with those of controls. Embryonic death was significantly higher among treated animals. The results indicated that /sup 35/S can induced dominant lethal mutations in immature oocytes.
Authors:
Satyanarayana Reddy, K; Reddy, P P; Reddi, O S [1] 
  1. Osmania Univ., Hyderabad (India). Dept. of Genetics
Publication Date:
Mar 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-08-330423; EDB-78-028624
Resource Relation:
Journal Name: Indian J. Med. Res.; (India); Journal Volume: 65:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DOMINANT MUTATIONS; RADIOINDUCTION; LETHAL MUTATIONS; OOCYTES; GENETIC RADIATION EFFECTS; SULFUR 35; MUTAGENESIS; EMBRYOS; INTRAPERITONEAL INJECTION; MICE; PREGNANCY; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; DAYS LIVING RADIOISOTOPES; EVEN-ODD NUCLEI; GENETIC EFFECTS; GERM CELLS; INJECTION; INTAKE; ISOTOPES; LIGHT NUCLEI; MAMMALS; MUTATIONS; NUCLEI; RADIATION EFFECTS; RADIOISOTOPES; RODENTS; SULFUR ISOTOPES; VERTEBRATES; 560162* - Radionuclide Effects, Kinetics, & Toxicology- Animals, Plants, Microorganisms, & Cells
OSTI ID:
5401472
Country of Origin:
India
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: IJMRA
Submitting Site:
INIS
Size:
Pages: 357-365
Announcement Date:
Dec 01, 1977

Journal Article:

Citation Formats

Satyanarayana Reddy, K, Reddy, P P, and Reddi, O S. /sup 35/S induced dominant lethals in immature oocytes in mice. India: N. p., 1977. Web.
Satyanarayana Reddy, K, Reddy, P P, & Reddi, O S. /sup 35/S induced dominant lethals in immature oocytes in mice. India.
Satyanarayana Reddy, K, Reddy, P P, and Reddi, O S. 1977. "/sup 35/S induced dominant lethals in immature oocytes in mice." India.
@misc{etde_5401472,
title = {/sup 35/S induced dominant lethals in immature oocytes in mice}
author = {Satyanarayana Reddy, K, Reddy, P P, and Reddi, O S}
abstractNote = {CBA female mice were injected intraperitoneally with a dose of 20..mu..Ci of sulphur-35 on 15.5 day post conception. Another group of pregnant mice injected with normal saline was kept as control. The pregnant females were allowed to litter and the mothers were separated from their offsprings 4 weeks after littering. Eight weeks after treatment i.e. at the age of 22 to 24 weeks, the treated mothers were mated with control C/sub 3/H/He males. The vaginal plugs were checked every morning and those which mated were separated. The pregnant females were killed on the 14th day of gestation. The uterine contents were examined for live and dead embryos and the ovaries for corpora lutea. The pre- and post-implantation losses and total loss were calculated in the treated females and compared with those of controls. Embryonic death was significantly higher among treated animals. The results indicated that /sup 35/S can induced dominant lethal mutations in immature oocytes.}
journal = {Indian J. Med. Res.; (India)}
volume = {65:3}
journal type = {AC}
place = {India}
year = {1977}
month = {Mar}
}