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The radioprotective effects of methylprednisolone and Sho-Saikoto on mouse lung

Journal Article:

Abstract

The radioprotective effects of methylprednisolone and Sho-Saikoto (a herbal medicine) on radiation damage to lung tissue were evaluated in four main groups of female Slc-ICR mice, one control group and three groups irradiated with single doses (6 Gy, 12 Gy, 18 Gy) of {sup 60}Co gamma rays. Subgroups were established with administration of methylprednisolone and Sho-Saikoto, alone and together. Direct quantitative measurements of collagen accumulation in lung (lung fibrosis) were made by analysis of digitally processed microscopic images of Azan-Mallory stained sections 24 weeks after irradiation. Administration of methylprednisolone supressed the expected development of fibrotic lung tissue in each of the irradiated groups. In a further study, peplomycin, a lung fibrosis enhancing agent, was administered to all four groups in addition to methylprednisolone and Sho-Saikoto, alone and together. Methylprednisolone was demonstrated to be effective only in 12 Gy group. Overall, Sho-Saikoto showed a lesser degree of effect in the prevention of the fibrosis than methylprednisolone, but the administration of both was demonstrated to be more effective than either alone. (author).
Authors:
Kure, Fumio [1] 
  1. Kyoto Prefectural Univ. of Medicine (Japan)
Publication Date:
Jan 01, 1992
Product Type:
Journal Article
Reference Number:
JPN-92-004324; EDB-92-091339
Resource Relation:
Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Nippon Acta Radiologica); (Japan); Journal Volume: 52:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LUNGS; RADIATION INJURIES; MEDICINAL PLANTS; RADIOPROTECTIVE SUBSTANCES; COLLAGEN; FIBROSIS; GAMMA RADIATION; MICE; PNEUMONITIS; PREDNISOLONE; RADIATION DOSES; RADIATION PROTECTION; ADRENAL HORMONES; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CORTICOSTEROIDS; DOSES; DRUGS; ELECTROMAGNETIC RADIATION; GLUCOCORTICOIDS; HORMONES; HYDROXY COMPOUNDS; INJURIES; IONIZING RADIATIONS; KETONES; MAMMALS; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PLANTS; PREGNANES; PROTEINS; RADIATION EFFECTS; RADIATIONS; RESPIRATORY SYSTEM; RODENTS; SCLEROPROTEINS; STEROID HORMONES; STEROIDS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
5400576
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0048-0428; CODEN: NHGZA
Submitting Site:
JPN
Size:
Pages: 96-103
Announcement Date:
Jun 15, 1992

Journal Article:

Citation Formats

Kure, Fumio. The radioprotective effects of methylprednisolone and Sho-Saikoto on mouse lung. Japan: N. p., 1992. Web.
Kure, Fumio. The radioprotective effects of methylprednisolone and Sho-Saikoto on mouse lung. Japan.
Kure, Fumio. 1992. "The radioprotective effects of methylprednisolone and Sho-Saikoto on mouse lung." Japan.
@misc{etde_5400576,
title = {The radioprotective effects of methylprednisolone and Sho-Saikoto on mouse lung}
author = {Kure, Fumio}
abstractNote = {The radioprotective effects of methylprednisolone and Sho-Saikoto (a herbal medicine) on radiation damage to lung tissue were evaluated in four main groups of female Slc-ICR mice, one control group and three groups irradiated with single doses (6 Gy, 12 Gy, 18 Gy) of {sup 60}Co gamma rays. Subgroups were established with administration of methylprednisolone and Sho-Saikoto, alone and together. Direct quantitative measurements of collagen accumulation in lung (lung fibrosis) were made by analysis of digitally processed microscopic images of Azan-Mallory stained sections 24 weeks after irradiation. Administration of methylprednisolone supressed the expected development of fibrotic lung tissue in each of the irradiated groups. In a further study, peplomycin, a lung fibrosis enhancing agent, was administered to all four groups in addition to methylprednisolone and Sho-Saikoto, alone and together. Methylprednisolone was demonstrated to be effective only in 12 Gy group. Overall, Sho-Saikoto showed a lesser degree of effect in the prevention of the fibrosis than methylprednisolone, but the administration of both was demonstrated to be more effective than either alone. (author).}
journal = {Nippon Igaku Hoshasen Gakkai Zasshi (Nippon Acta Radiologica); (Japan)}
volume = {52:1}
journal type = {AC}
place = {Japan}
year = {1992}
month = {Jan}
}