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Effect of irradiation on T-cell suppression of ELISA-determined Ig production by human blood B-cells in vitro

Abstract

Human blood B-lymphocytes were co-cultured with in vitro irradiated allogeneic or autologous T-lymphocytes in the presence of pokeweed mitogen (PWM). The production of IgG, IgM and IgA, as assessed by the enzyme-linked immunosorbent assay (ELISA) was increased 2-7 times, as compared to values obtained with non-irradiated T-lymphocytes. It was suggested that the increase of Ig production was due to the selective radiosensitivity of T-lymphocytes with suppressor function. (author).
Authors:
Wasserman, J; Stedingk, L.V. von; Biberfeld, G; Petrini, B; Blomgren, H; Baral, E [1] 
  1. Central Microbiologcal Lab. of Stockholm County Council (Sweden)
Publication Date:
Nov 01, 1979
Product Type:
Journal Article
Reference Number:
AIX-11-505064; EDB-80-073043
Resource Relation:
Journal Name: Clin. Exp. Immunol.; (United Kingdom); Journal Volume: 38:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; IMMUNOGLOBULINS; IMMUNOSUPPRESSION; LYMPHOCYTES; RADIOSENSITIVITY; X RADIATION; BIOLOGICAL RADIATION EFFECTS; CELL CULTURES; EXTERNAL IRRADIATION; IN VITRO; MAN; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; GLOBULINS; IONIZING RADIATIONS; IRRADIATION; LEUKOCYTES; MAMMALS; MATERIALS; ORGANIC COMPOUNDS; PRIMATES; PROTEINS; RADIATION EFFECTS; RADIATIONS; SOMATIC CELLS; VERTEBRATES; 560121* - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
5393979
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CEXIA
Submitting Site:
INIS
Size:
Pages: 366-369
Announcement Date:
May 01, 1980

Citation Formats

Wasserman, J, Stedingk, L.V. von, Biberfeld, G, Petrini, B, Blomgren, H, and Baral, E. Effect of irradiation on T-cell suppression of ELISA-determined Ig production by human blood B-cells in vitro. United Kingdom: N. p., 1979. Web.
Wasserman, J, Stedingk, L.V. von, Biberfeld, G, Petrini, B, Blomgren, H, & Baral, E. Effect of irradiation on T-cell suppression of ELISA-determined Ig production by human blood B-cells in vitro. United Kingdom.
Wasserman, J, Stedingk, L.V. von, Biberfeld, G, Petrini, B, Blomgren, H, and Baral, E. 1979. "Effect of irradiation on T-cell suppression of ELISA-determined Ig production by human blood B-cells in vitro." United Kingdom.
@misc{etde_5393979,
title = {Effect of irradiation on T-cell suppression of ELISA-determined Ig production by human blood B-cells in vitro}
author = {Wasserman, J, Stedingk, L.V. von, Biberfeld, G, Petrini, B, Blomgren, H, and Baral, E}
abstractNote = {Human blood B-lymphocytes were co-cultured with in vitro irradiated allogeneic or autologous T-lymphocytes in the presence of pokeweed mitogen (PWM). The production of IgG, IgM and IgA, as assessed by the enzyme-linked immunosorbent assay (ELISA) was increased 2-7 times, as compared to values obtained with non-irradiated T-lymphocytes. It was suggested that the increase of Ig production was due to the selective radiosensitivity of T-lymphocytes with suppressor function. (author).}
journal = []
volume = {38:2}
journal type = {AC}
place = {United Kingdom}
year = {1979}
month = {Nov}
}