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Enhancement of intrinsic antitumor activity in spore-endotoxin mixtures of Bacillus thuringiensis by exposure to ultraviolet radiation

Abstract

Irradiation of spore-endotoxin mixtures from Bacillus thuringiensis cultures at 254 nm (60 ..mu..W cm/sup -2/) enhances their intrinsic antitumor potency as well as that of either component. The extent of enhancement depends on the length of exposure (optimum: 35 min) and may thus be due to photochemical changes of the endotoxin protein or/and to photoproduction of additional compounds with antitumor activity. Antitumor effects, expressed as survival rates of C57BL/6 mice inoculated with Lewis' mouse lung carcinoma and subjected to treatments 24 h later, depended on the number of doses of preparations administered (mixture, separated components).
Authors:
Zamola, B; Karminski-Zamola, G; Fuks, Z; Kubovic, M; [1]  Wrishcer, M [2] 
  1. Zagreb Univ. (Yugoslavia)
  2. Institut Rudjer Boskovic, Zagreb (Yugoslavia)
Publication Date:
Mar 01, 1985
Product Type:
Journal Article
Reference Number:
AIX-16-060447; EDB-85-149874
Resource Relation:
Journal Name: Photochem. Photobiol.; (United Kingdom); Journal Volume: 41:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BACILLUS; BIOLOGICAL RADIATION EFFECTS; DOSE-RESPONSE RELATIONSHIPS; ENDOTOXINS; NEAR ULTRAVIOLET RADIATION; RESPONSE MODIFYING FACTORS; SPORES; TIME DEPENDENCE; TUMOR CELLS; ANIMAL CELLS; ANTIGENS; BACTERIA; BIOLOGICAL EFFECTS; ELECTROMAGNETIC RADIATION; MATERIALS; MICROORGANISMS; RADIATION EFFECTS; RADIATIONS; TOXIC MATERIALS; TOXINS; ULTRAVIOLET RADIATION; 560131* - Radiation Effects on Microorganisms- Basic Studies- (-1987)
OSTI ID:
5378036
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: PHCBA
Submitting Site:
HEDB
Size:
Pages: 361-365
Announcement Date:

Citation Formats

Zamola, B, Karminski-Zamola, G, Fuks, Z, Kubovic, M, and Wrishcer, M. Enhancement of intrinsic antitumor activity in spore-endotoxin mixtures of Bacillus thuringiensis by exposure to ultraviolet radiation. United Kingdom: N. p., 1985. Web. doi:10.1111/j.1751-1097.1985.tb03498.x.
Zamola, B, Karminski-Zamola, G, Fuks, Z, Kubovic, M, & Wrishcer, M. Enhancement of intrinsic antitumor activity in spore-endotoxin mixtures of Bacillus thuringiensis by exposure to ultraviolet radiation. United Kingdom. doi:10.1111/j.1751-1097.1985.tb03498.x.
Zamola, B, Karminski-Zamola, G, Fuks, Z, Kubovic, M, and Wrishcer, M. 1985. "Enhancement of intrinsic antitumor activity in spore-endotoxin mixtures of Bacillus thuringiensis by exposure to ultraviolet radiation." United Kingdom. doi:10.1111/j.1751-1097.1985.tb03498.x. https://www.osti.gov/servlets/purl/10.1111/j.1751-1097.1985.tb03498.x.
@misc{etde_5378036,
title = {Enhancement of intrinsic antitumor activity in spore-endotoxin mixtures of Bacillus thuringiensis by exposure to ultraviolet radiation}
author = {Zamola, B, Karminski-Zamola, G, Fuks, Z, Kubovic, M, and Wrishcer, M}
abstractNote = {Irradiation of spore-endotoxin mixtures from Bacillus thuringiensis cultures at 254 nm (60 ..mu..W cm/sup -2/) enhances their intrinsic antitumor potency as well as that of either component. The extent of enhancement depends on the length of exposure (optimum: 35 min) and may thus be due to photochemical changes of the endotoxin protein or/and to photoproduction of additional compounds with antitumor activity. Antitumor effects, expressed as survival rates of C57BL/6 mice inoculated with Lewis' mouse lung carcinoma and subjected to treatments 24 h later, depended on the number of doses of preparations administered (mixture, separated components).}
doi = {10.1111/j.1751-1097.1985.tb03498.x}
journal = {Photochem. Photobiol.; (United Kingdom)}
volume = {41:3}
journal type = {AC}
place = {United Kingdom}
year = {1985}
month = {Mar}
}