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Inactivation of hemopoietic stem cells by lymphocytes as related to genotype of interacting cells

Journal Article:

Abstract

Inoculation of a mixture of bone marrow cells with allogeneic lymphocytes into irradiated mice of inbred strains or into F/sub 1/ hybrids results in the depression of bone marrow cell proliferation in the spleen of the recipient: the effect of inactivation of nonsyngeneic stem cells. The inactivation of stem cells by allogeneic lymphocytes can be detected in all tested combinations of mice strains - donors of lymphocytes and bone marrow cells and mice - recipients but the degree of inactivation differs and depends on the genotype of cell donors rather than on the genotype of the recipient. Lymphocytes of some mice strains (haplotypes H-2sup(k) and H-2sup(a)) are more active killers of bone marrow cells as compared with lymphocytes of other strains (hyplotypes H-2sup(b) and H-2sup(d)). Probably, the degree of stem cells inactivation by lymphocytes depends on the differences of their histocompatibility in H-2 system.
Publication Date:
May 01, 1975
Product Type:
Journal Article
Reference Number:
AIX-09-354790; EDB-78-034204
Resource Relation:
Journal Name: Tsitologiya; (USSR); Journal Volume: 17:5
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; IMMUNE REACTIONS; BIOLOGICAL RADIATION EFFECTS; STEM CELLS; INACTIVATION; BONE MARROW CELLS; CFU; GENOTYPE; HAPLOIDY; IRRADIATION; LYMPHOCYTES; MICE; SPLEEN COLONY FORMATION; TRANSPLANTS; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; COLONY FORMATION; CONNECTIVE TISSUE CELLS; LEUKOCYTES; MAMMALS; PLOIDY; RADIATION EFFECTS; RODENTS; SOMATIC CELLS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
5369821
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: TSITA
Submitting Site:
INIS
Size:
Pages: 560-564
Announcement Date:

Journal Article:

Citation Formats

Petrov, R V, Seslavina, L S, Panteleev, E I, and Egorova, O S. Inactivation of hemopoietic stem cells by lymphocytes as related to genotype of interacting cells. USSR: N. p., 1975. Web.
Petrov, R V, Seslavina, L S, Panteleev, E I, & Egorova, O S. Inactivation of hemopoietic stem cells by lymphocytes as related to genotype of interacting cells. USSR.
Petrov, R V, Seslavina, L S, Panteleev, E I, and Egorova, O S. 1975. "Inactivation of hemopoietic stem cells by lymphocytes as related to genotype of interacting cells." USSR.
@misc{etde_5369821,
title = {Inactivation of hemopoietic stem cells by lymphocytes as related to genotype of interacting cells}
author = {Petrov, R V, Seslavina, L S, Panteleev, E I, and Egorova, O S}
abstractNote = {Inoculation of a mixture of bone marrow cells with allogeneic lymphocytes into irradiated mice of inbred strains or into F/sub 1/ hybrids results in the depression of bone marrow cell proliferation in the spleen of the recipient: the effect of inactivation of nonsyngeneic stem cells. The inactivation of stem cells by allogeneic lymphocytes can be detected in all tested combinations of mice strains - donors of lymphocytes and bone marrow cells and mice - recipients but the degree of inactivation differs and depends on the genotype of cell donors rather than on the genotype of the recipient. Lymphocytes of some mice strains (haplotypes H-2sup(k) and H-2sup(a)) are more active killers of bone marrow cells as compared with lymphocytes of other strains (hyplotypes H-2sup(b) and H-2sup(d)). Probably, the degree of stem cells inactivation by lymphocytes depends on the differences of their histocompatibility in H-2 system.}
journal = {Tsitologiya; (USSR)}
volume = {17:5}
journal type = {AC}
place = {USSR}
year = {1975}
month = {May}
}