Abstract
Inoculation of a mixture of bone marrow cells with allogeneic lymphocytes into irradiated mice of inbred strains or into F/sub 1/ hybrids results in the depression of bone marrow cell proliferation in the spleen of the recipient: the effect of inactivation of nonsyngeneic stem cells. The inactivation of stem cells by allogeneic lymphocytes can be detected in all tested combinations of mice strains - donors of lymphocytes and bone marrow cells and mice - recipients but the degree of inactivation differs and depends on the genotype of cell donors rather than on the genotype of the recipient. Lymphocytes of some mice strains (haplotypes H-2sup(k) and H-2sup(a)) are more active killers of bone marrow cells as compared with lymphocytes of other strains (hyplotypes H-2sup(b) and H-2sup(d)). Probably, the degree of stem cells inactivation by lymphocytes depends on the differences of their histocompatibility in H-2 system.
Citation Formats
Petrov, R V, Seslavina, L S, Panteleev, E I, and Egorova, O S.
Inactivation of hemopoietic stem cells by lymphocytes as related to genotype of interacting cells.
USSR: N. p.,
1975.
Web.
Petrov, R V, Seslavina, L S, Panteleev, E I, & Egorova, O S.
Inactivation of hemopoietic stem cells by lymphocytes as related to genotype of interacting cells.
USSR.
Petrov, R V, Seslavina, L S, Panteleev, E I, and Egorova, O S.
1975.
"Inactivation of hemopoietic stem cells by lymphocytes as related to genotype of interacting cells."
USSR.
@misc{etde_5369821,
title = {Inactivation of hemopoietic stem cells by lymphocytes as related to genotype of interacting cells}
author = {Petrov, R V, Seslavina, L S, Panteleev, E I, and Egorova, O S}
abstractNote = {Inoculation of a mixture of bone marrow cells with allogeneic lymphocytes into irradiated mice of inbred strains or into F/sub 1/ hybrids results in the depression of bone marrow cell proliferation in the spleen of the recipient: the effect of inactivation of nonsyngeneic stem cells. The inactivation of stem cells by allogeneic lymphocytes can be detected in all tested combinations of mice strains - donors of lymphocytes and bone marrow cells and mice - recipients but the degree of inactivation differs and depends on the genotype of cell donors rather than on the genotype of the recipient. Lymphocytes of some mice strains (haplotypes H-2sup(k) and H-2sup(a)) are more active killers of bone marrow cells as compared with lymphocytes of other strains (hyplotypes H-2sup(b) and H-2sup(d)). Probably, the degree of stem cells inactivation by lymphocytes depends on the differences of their histocompatibility in H-2 system.}
journal = []
volume = {17:5}
journal type = {AC}
place = {USSR}
year = {1975}
month = {May}
}
title = {Inactivation of hemopoietic stem cells by lymphocytes as related to genotype of interacting cells}
author = {Petrov, R V, Seslavina, L S, Panteleev, E I, and Egorova, O S}
abstractNote = {Inoculation of a mixture of bone marrow cells with allogeneic lymphocytes into irradiated mice of inbred strains or into F/sub 1/ hybrids results in the depression of bone marrow cell proliferation in the spleen of the recipient: the effect of inactivation of nonsyngeneic stem cells. The inactivation of stem cells by allogeneic lymphocytes can be detected in all tested combinations of mice strains - donors of lymphocytes and bone marrow cells and mice - recipients but the degree of inactivation differs and depends on the genotype of cell donors rather than on the genotype of the recipient. Lymphocytes of some mice strains (haplotypes H-2sup(k) and H-2sup(a)) are more active killers of bone marrow cells as compared with lymphocytes of other strains (hyplotypes H-2sup(b) and H-2sup(d)). Probably, the degree of stem cells inactivation by lymphocytes depends on the differences of their histocompatibility in H-2 system.}
journal = []
volume = {17:5}
journal type = {AC}
place = {USSR}
year = {1975}
month = {May}
}