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Regional cerebral blood flow and oxygen consumption during normal human sleep

Abstract

Regional cerebral blood flow (rCBF), regional oxygen extraction fraction (rCEF) and regional cerebral metabolic rate for oxygen (rCMRO{sub 2}) were measured using the continuous inhalation technique for {sup 15}O with positron emission tomography (PET) during both wakefulness and sleep. Ten paid volunteers, with a mean age of 21.6 yrs., were deprived of sleep for a period of approximately 20 hours, and the experiments were performed mostly in the morning. {sup 15}O activity of both whole blood and the plasma, pixel count of PET, total arterial blood oxygen content were used for analysis of rCBF, rOEF and rCMRO{sub 2}. PET scannings were carried out mostly during the very light non-rapid eye movement (NREM) sleep, i.e. stage 1 and/or 2, and wakefulness. About 10 minutes after the start of continuous inhalation of {sup 15}O gas, the {sup 15}O activity of the brain was found to be in a steady-state condition. During this steady-state condition, PET scannings were performed for about 10 minutes. Regions of interest, square in shape and having an area of 2.8 cm{sup 3}, were set in each cortex on PET images of a horizontal cross-section of the brain, set at 45 mm above the orbitomeatal line. The rCBF and  More>>
Authors:
Takahashi, Ken [1] 
  1. Toho Univ., Tokyo (Japan). School of Medicine
Publication Date:
Sep 01, 1989
Product Type:
Journal Article
Reference Number:
JPN-89-014236; EDB-90-011429
Resource Relation:
Journal Name: No To Shinkei; (Japan); Journal Volume: 41:9
Subject:
60 APPLIED LIFE SCIENCES; CEREBRUM; BLOOD FLOW; POSITRON COMPUTED TOMOGRAPHY; OXYGEN 15; ARTERIES; BREATH; ELECTROENCEPHALOGRAPHY; IMAGES; INHALATION; METABOLISM; REFERENCE MAN; SLEEP; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BLOOD VESSELS; BODY; BRAIN; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; INTAKE; ISOTOPES; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; ORGANS; OXYGEN ISOTOPES; RADIOISOTOPES; TOMOGRAPHY; 553006* - Agriculture & Food Technology- Other Agricultural Applications- (1987-)
OSTI ID:
5357871
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0006-8969; CODEN: NOTOA
Submitting Site:
JPN
Size:
Pages: 919-925
Announcement Date:
Jan 15, 1990

Citation Formats

Takahashi, Ken. Regional cerebral blood flow and oxygen consumption during normal human sleep. Japan: N. p., 1989. Web.
Takahashi, Ken. Regional cerebral blood flow and oxygen consumption during normal human sleep. Japan.
Takahashi, Ken. 1989. "Regional cerebral blood flow and oxygen consumption during normal human sleep." Japan.
@misc{etde_5357871,
title = {Regional cerebral blood flow and oxygen consumption during normal human sleep}
author = {Takahashi, Ken}
abstractNote = {Regional cerebral blood flow (rCBF), regional oxygen extraction fraction (rCEF) and regional cerebral metabolic rate for oxygen (rCMRO{sub 2}) were measured using the continuous inhalation technique for {sup 15}O with positron emission tomography (PET) during both wakefulness and sleep. Ten paid volunteers, with a mean age of 21.6 yrs., were deprived of sleep for a period of approximately 20 hours, and the experiments were performed mostly in the morning. {sup 15}O activity of both whole blood and the plasma, pixel count of PET, total arterial blood oxygen content were used for analysis of rCBF, rOEF and rCMRO{sub 2}. PET scannings were carried out mostly during the very light non-rapid eye movement (NREM) sleep, i.e. stage 1 and/or 2, and wakefulness. About 10 minutes after the start of continuous inhalation of {sup 15}O gas, the {sup 15}O activity of the brain was found to be in a steady-state condition. During this steady-state condition, PET scannings were performed for about 10 minutes. Regions of interest, square in shape and having an area of 2.8 cm{sup 3}, were set in each cortex on PET images of a horizontal cross-section of the brain, set at 45 mm above the orbitomeatal line. The rCBF and rCMRO{sub 2} were analysed in 5 of 10 male subjects during both wakefulness and NREM sleep, and only 3 were done during three sleep stages, including REM sleep. Levels of rCBF and rCMRO{sub 2} were found to be decreased in NREM sleep, and the decreasing rates were calculated at 10.2% and 7.6% from the level of wakefulness, respectively. There was no significant difference in the mean value of rOEF between wakefulness and NREM sleep. There were no significant regional differences found in the rate of decrease among the frontal, temporal and occipital cortices. It was considered that the decrease of rCBF and rCMRO{sub 2} during NREM sleep suggested a decrease of the activity levels in the cerebral functions. (author).}
journal = []
volume = {41:9}
journal type = {AC}
place = {Japan}
year = {1989}
month = {Sep}
}