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Fractionated homogenous total-body irradiation prior to bone marrow transplantation

Abstract

At the University of Kiel, myeloid and acute lymphatic leukemia is treated since 1983 by total-body irradiation applied prior to bone marrow transplantation. Dose deviations in the midplane caused by the irregular surface and tissue inhomogeneities of the patient are reduced down to +-3.5% compared to the central ray, with the help of CT-based individual compensators. This method prevents above all an excessive dose to the lungs. The radiobiologic advantages of fractionated irradiation have been employed for all patients treated hitherto (n = 9). At present, a total body dose of 12 Gy in six fractions is applied within three days. There were no undesired acute radiogenic reactions except a mild acute mucositis found in all patients. Chronic side effects, especially in the lungs, were not demonstrated, too. However, the average follow-up time of 149 days has been rather short. One patient died from relapse of leukemia after a total dose of 10 Gy, another patient died because the transplanted bone marrow was rejected, and a third died from catheter sepsis. Six out of nine patients are in complete remission with a maximum index of Karnofsky. The limited experiences gained hitherto show that the homogeneous accelerated-fractionated total-body irradiation offers essential  More>>
Publication Date:
Mar 01, 1985
Product Type:
Conference
Report Number:
CONF-8405341-
Reference Number:
FRG-84-06869; EDB-85-142082
Resource Relation:
Journal Name: Strahlentherapie; (Germany, Federal Republic of); Journal Volume: 161:3; Conference: 65. German radiological congress, Baden-Baden, F.R. Germany, 30 May 1984
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BONE MARROW; TRANSPLANTS; IRRADIATION PROCEDURES; COMPARATIVE EVALUATIONS; LEUKEMIA; FRACTIONATED IRRADIATION; WHOLE-BODY IRRADIATION; CRITICAL ORGANS; GRAFT-HOST REACTION; PATIENTS; RADIATION CHIMERAS; RADIATION DOSES; RADIATION INJURIES; RADIOTHERAPY; SIDE EFFECTS; SURVIVAL TIME; ANIMAL TISSUES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CHIMERAS; DISEASES; DOSES; EXTERNAL IRRADIATION; HEMATOPOIETIC SYSTEM; HEMIC DISEASES; INJURIES; IRRADIATION; MEDICINE; MOSAICISM; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; RADIATION EFFECTS; RADIOLOGY; THERAPY; TISSUES; 550603* - Medicine- External Radiation in Therapy- (1980-)
OSTI ID:
5356427
Country of Origin:
Germany
Language:
German
Other Identifying Numbers:
Journal ID: CODEN: STRAA
Submitting Site:
HEDB
Size:
Pages: 134-139
Announcement Date:

Citation Formats

Duehmke, E, Brix, F, Hebbinghaus, D, Jensen, M, Wendhausen, H, and Schmitz, N. Fractionated homogenous total-body irradiation prior to bone marrow transplantation. Germany: N. p., 1985. Web.
Duehmke, E, Brix, F, Hebbinghaus, D, Jensen, M, Wendhausen, H, & Schmitz, N. Fractionated homogenous total-body irradiation prior to bone marrow transplantation. Germany.
Duehmke, E, Brix, F, Hebbinghaus, D, Jensen, M, Wendhausen, H, and Schmitz, N. 1985. "Fractionated homogenous total-body irradiation prior to bone marrow transplantation." Germany.
@misc{etde_5356427,
title = {Fractionated homogenous total-body irradiation prior to bone marrow transplantation}
author = {Duehmke, E, Brix, F, Hebbinghaus, D, Jensen, M, Wendhausen, H, and Schmitz, N}
abstractNote = {At the University of Kiel, myeloid and acute lymphatic leukemia is treated since 1983 by total-body irradiation applied prior to bone marrow transplantation. Dose deviations in the midplane caused by the irregular surface and tissue inhomogeneities of the patient are reduced down to +-3.5% compared to the central ray, with the help of CT-based individual compensators. This method prevents above all an excessive dose to the lungs. The radiobiologic advantages of fractionated irradiation have been employed for all patients treated hitherto (n = 9). At present, a total body dose of 12 Gy in six fractions is applied within three days. There were no undesired acute radiogenic reactions except a mild acute mucositis found in all patients. Chronic side effects, especially in the lungs, were not demonstrated, too. However, the average follow-up time of 149 days has been rather short. One patient died from relapse of leukemia after a total dose of 10 Gy, another patient died because the transplanted bone marrow was rejected, and a third died from catheter sepsis. Six out of nine patients are in complete remission with a maximum index of Karnofsky. The limited experiences gained hitherto show that the homogeneous accelerated-fractionated total-body irradiation offers essential advantages compared to non-compensated single dose irradiation with respect to the prevention of undesired radiogenic effects in sound tissues and that its therapeutic efficacy is at least the same.}
journal = {Strahlentherapie; (Germany, Federal Republic of)}
volume = {161:3}
place = {Germany}
year = {1985}
month = {Mar}
}