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Radiation pancreatic death. A new radiation injury and its pathologic physiology

Journal Article:

Abstract

In lethal radiation injury, the organ which is responsible for gastrointestinal death was sought from the relationship between radiation dose and survival length of hamsters. In this research, a new plateau was found in the range of radiation dose from 30,000 to 60,000 rad. Histological examination revealed that the organ responsible to the survival of the animals in the plateau was Langerhans's (L.'s) island of the pancreas. Acute necrotic changes of L.'s islands was disclosed by blood glucose level, changes in granules of ..cap alpha.. and ..beta.. cells, atrophy of L.'s islands, and by deficiency of blood insulin. The death of hamsters in the plateau is probably due to diabetic syndrome which was induced by the necrosis of L.'s island.
Authors:
Tsubouchi, Susumu [1] 
  1. Fukui Medical School, Fukui (Japan)
Publication Date:
Mar 01, 1982
Product Type:
Journal Article
Reference Number:
AIX-14-806032; EDB-84-032159
Resource Relation:
Journal Name: Hoshasen Seibutsu Kenkyu; (Japan); Journal Volume: 17:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; PANCREAS; LETHAL IRRADIATION; RADIATION INJURIES; BIOLOGICAL FUNCTIONS; DIABETES MELLITUS; DOSE-RESPONSE RELATIONSHIPS; HAMSTERS; INSULIN; NECROSIS; SURVIVAL CURVES; SURVIVAL TIME; ULTRASTRUCTURAL CHANGES; WHOLE-BODY IRRADIATION; X RADIATION; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DIGESTIVE SYSTEM; DISEASES; ELECTROMAGNETIC RADIATION; ENDOCRINE DISEASES; ENDOCRINE GLANDS; EXTERNAL IRRADIATION; FUNCTIONS; GLANDS; HORMONES; INJURIES; IONIZING RADIATIONS; IRRADIATION; MAMMALS; METABOLIC DISEASES; MORPHOLOGICAL CHANGES; ORGANS; PATHOLOGICAL CHANGES; PEPTIDE HORMONES; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
5347686
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: HSKEA
Submitting Site:
HEDB
Size:
Pages: 26-42
Announcement Date:

Journal Article:

Citation Formats

Tsubouchi, Susumu. Radiation pancreatic death. A new radiation injury and its pathologic physiology. Japan: N. p., 1982. Web.
Tsubouchi, Susumu. Radiation pancreatic death. A new radiation injury and its pathologic physiology. Japan.
Tsubouchi, Susumu. 1982. "Radiation pancreatic death. A new radiation injury and its pathologic physiology." Japan.
@misc{etde_5347686,
title = {Radiation pancreatic death. A new radiation injury and its pathologic physiology}
author = {Tsubouchi, Susumu}
abstractNote = {In lethal radiation injury, the organ which is responsible for gastrointestinal death was sought from the relationship between radiation dose and survival length of hamsters. In this research, a new plateau was found in the range of radiation dose from 30,000 to 60,000 rad. Histological examination revealed that the organ responsible to the survival of the animals in the plateau was Langerhans's (L.'s) island of the pancreas. Acute necrotic changes of L.'s islands was disclosed by blood glucose level, changes in granules of ..cap alpha.. and ..beta.. cells, atrophy of L.'s islands, and by deficiency of blood insulin. The death of hamsters in the plateau is probably due to diabetic syndrome which was induced by the necrosis of L.'s island.}
journal = {Hoshasen Seibutsu Kenkyu; (Japan)}
volume = {17:1}
journal type = {AC}
place = {Japan}
year = {1982}
month = {Mar}
}