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Simple method for the estimation of glomerular filtration rate

Journal Article:

Abstract

A simple method is presented for indirect estimation of the glomerular filtration rate from two venous blood samples, drawn after a single injection of a small dose of (/sup 125/I)sodium iothalamate (10 ..mu..Ci). The method does not require exact dosage, as the first sample, taken after a few minutes (t=5 min) after injection, is used to normilize the value of the second sample, which should be taken in between 2 to 4 h after injection. The glomerular filtration rate, as measured by standard insulin clearance, may then be predicted from the logarithm of the normalized value and linear regression formulas with a standard error of estimate of the order of 1 to 2 ml/min/1.73 m/sup 2/. The slope-intercept method for direct estimation of glomerular filtration rate is also evaluated and found to significantly underestimate standard insulin clearance. The normalized 'single-point' method is concluded to be superior to the slope-intercept method and more sophisticated methods using curve fitting technique, with regard to predictive force and clinical applicability.
Authors:
Groth, T; [1]  Tengstroem, B [2] 
  1. Group for Biomedical Informatics, Uppsala Univ. Data Center, Uppsala (Sweden)
  2. District General Hospital, Skoevde (Sweden)
Publication Date:
Feb 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-08-330469; EDB-78-028507
Resource Relation:
Journal Name: Scand. J. Clin. Lab. Invest.; (Norway); Journal Volume: 37:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; GLOMERULI; ULTRAFILTRATION; MEASURING METHODS; ACCURACY; ERRORS; IODINE 125; ORGANIC IODINE COMPOUNDS; SODIUM COMPOUNDS; ALKALI METAL COMPOUNDS; BETA DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; KIDNEYS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANS; RADIOISOTOPES; SEPARATION PROCESSES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5332649
Country of Origin:
Norway
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: SJCLA
Submitting Site:
INIS
Size:
Pages: 39-47
Announcement Date:

Journal Article:

Citation Formats

Groth, T, and Tengstroem, B. Simple method for the estimation of glomerular filtration rate. Norway: N. p., 1977. Web.
Groth, T, & Tengstroem, B. Simple method for the estimation of glomerular filtration rate. Norway.
Groth, T, and Tengstroem, B. 1977. "Simple method for the estimation of glomerular filtration rate." Norway.
@misc{etde_5332649,
title = {Simple method for the estimation of glomerular filtration rate}
author = {Groth, T, and Tengstroem, B}
abstractNote = {A simple method is presented for indirect estimation of the glomerular filtration rate from two venous blood samples, drawn after a single injection of a small dose of (/sup 125/I)sodium iothalamate (10 ..mu..Ci). The method does not require exact dosage, as the first sample, taken after a few minutes (t=5 min) after injection, is used to normilize the value of the second sample, which should be taken in between 2 to 4 h after injection. The glomerular filtration rate, as measured by standard insulin clearance, may then be predicted from the logarithm of the normalized value and linear regression formulas with a standard error of estimate of the order of 1 to 2 ml/min/1.73 m/sup 2/. The slope-intercept method for direct estimation of glomerular filtration rate is also evaluated and found to significantly underestimate standard insulin clearance. The normalized 'single-point' method is concluded to be superior to the slope-intercept method and more sophisticated methods using curve fitting technique, with regard to predictive force and clinical applicability.}
journal = {Scand. J. Clin. Lab. Invest.; (Norway)}
volume = {37:1}
journal type = {AC}
place = {Norway}
year = {1977}
month = {Feb}
}