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Reduction of superoxide dismutase activity correlates with visualization of edema by T[sub 2]-weighted MR imaging in focal ischemic rat brain

Journal Article:

Abstract

This study investigated the correlation between in vivo serial T[sub 2]-weighted magnetic resonance (MR) imaging and changes in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, and water, sodium ion (Na[sup +]), and potassium ion (K[sup +]) contents measured in vitro using rat brain following right middle cerebral artery occlusion in conjunction with bilateral common carotid artery (CCA) occlusion. One hour later the left CCA was released. Serial MR images showed edema developed from the outer cortex towards the center. The T[sub 2] signal intensity of the injured right cortex increased with time compared to that of the contralateral cortex. Increased Na[sup +] and water and decreased K[sup +] contents occurred in the injured cortex, indicating that serial T[sub 2]-weighted MR imaging reflects the changes in water content and Na[sup +] and K[sup +] concentrations determined by biochemical techniques. GSH-Px activity was little changed. Total SOD in the injured cortex decreased 1 hour after ischemia and remained low throughout the experiment. In contrast, SOD activity in the noninfarcted left cortex also decreased after 1 hour but returned to normal after 2 hours of ischemia. Our results suggest that oxygen free radicals are important in developing ischemic brain edema and cerebral  More>>
Authors:
Imaizumi, Shigeki; Chang, LeeHong; Cohen, Yoram; Chan, P H; Weinstein, P R; James, T L; [1]  Yoshimoto, Takashi
  1. California Univ., San Francisco, CA (United States)
Publication Date:
Jan 01, 1994
Product Type:
Journal Article
Reference Number:
JPN-94-002370; EDB-94-057467
Resource Relation:
Journal Name: Neurologia Medico-Chirurgica; (Japan); Journal Volume: 34:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CEREBRUM; SPIN-SPIN RELAXATION; ARTERIES; EDEMA; GLUTATHIONE; INJURIES; ISCHEMIA; NMR IMAGING; RATS; SUPEROXIDE DISMUTASE; VASCULAR DISEASES; ANEMIAS; ANIMALS; BLOOD VESSELS; BODY; BRAIN; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ENZYMES; HEMIC DISEASES; MAMMALS; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANS; OXIDOREDUCTASES; PATHOLOGICAL CHANGES; PEPTIDES; POLYPEPTIDES; PROTEINS; RADIOPROTECTIVE SUBSTANCES; RELAXATION; RODENTS; SYMPTOMS; VERTEBRATES; 550602* - Medicine- External Radiation in Diagnostics- (1980-)
OSTI ID:
5330235
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0387-2572; CODEN: NMCHBN
Submitting Site:
JPN
Size:
Pages: 1-9
Announcement Date:

Journal Article:

Citation Formats

Imaizumi, Shigeki, Chang, LeeHong, Cohen, Yoram, Chan, P H, Weinstein, P R, James, T L, and Yoshimoto, Takashi. Reduction of superoxide dismutase activity correlates with visualization of edema by T[sub 2]-weighted MR imaging in focal ischemic rat brain. Japan: N. p., 1994. Web.
Imaizumi, Shigeki, Chang, LeeHong, Cohen, Yoram, Chan, P H, Weinstein, P R, James, T L, & Yoshimoto, Takashi. Reduction of superoxide dismutase activity correlates with visualization of edema by T[sub 2]-weighted MR imaging in focal ischemic rat brain. Japan.
Imaizumi, Shigeki, Chang, LeeHong, Cohen, Yoram, Chan, P H, Weinstein, P R, James, T L, and Yoshimoto, Takashi. 1994. "Reduction of superoxide dismutase activity correlates with visualization of edema by T[sub 2]-weighted MR imaging in focal ischemic rat brain." Japan.
@misc{etde_5330235,
title = {Reduction of superoxide dismutase activity correlates with visualization of edema by T[sub 2]-weighted MR imaging in focal ischemic rat brain}
author = {Imaizumi, Shigeki, Chang, LeeHong, Cohen, Yoram, Chan, P H, Weinstein, P R, James, T L, and Yoshimoto, Takashi}
abstractNote = {This study investigated the correlation between in vivo serial T[sub 2]-weighted magnetic resonance (MR) imaging and changes in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, and water, sodium ion (Na[sup +]), and potassium ion (K[sup +]) contents measured in vitro using rat brain following right middle cerebral artery occlusion in conjunction with bilateral common carotid artery (CCA) occlusion. One hour later the left CCA was released. Serial MR images showed edema developed from the outer cortex towards the center. The T[sub 2] signal intensity of the injured right cortex increased with time compared to that of the contralateral cortex. Increased Na[sup +] and water and decreased K[sup +] contents occurred in the injured cortex, indicating that serial T[sub 2]-weighted MR imaging reflects the changes in water content and Na[sup +] and K[sup +] concentrations determined by biochemical techniques. GSH-Px activity was little changed. Total SOD in the injured cortex decreased 1 hour after ischemia and remained low throughout the experiment. In contrast, SOD activity in the noninfarcted left cortex also decreased after 1 hour but returned to normal after 2 hours of ischemia. Our results suggest that oxygen free radicals are important in developing ischemic brain edema and cerebral infarction. (author).}
journal = {Neurologia Medico-Chirurgica; (Japan)}
volume = {34:1}
journal type = {AC}
place = {Japan}
year = {1994}
month = {Jan}
}