Abstract
The heads of rats were irradiated by 4 MeV electrons in doses 90, 180, and 360 Gy. The observed times of deaths ranged 120-600, 60-420, and 150-370 min after 90, 180, and 360 Gy, respectively. A dose dependent decrease of the brain uptake index of haloperidol was observed 1 and 3 h post radiation. On the other hand an increased brain uptake index was found for stobadin after head irradiation with doses of 180 and 360 Gy. Regional cerebral blood flow, blood pressure, and heart rate were not significantly altered in the period following irradiation with 180 Gy. The observed changes in blood-brain barrier (BBB) permeability seem to be the result of the damaged function of morphological structures forming the BBB rather than altered regional blood flow. (orig.).
Trnovec, T;
Kallay, Z;
[1]
Volenec, K;
[2]
Bezek, S;
Durisova, M;
Scasnar, V;
Kubu, M;
[3]
Svoboda, V
[4]
- Komenskeho Univ., Bratislava (Czechoslovakia). Inst. of Preventive and Clinical Medicine
- Karlova Univ., Hradec Kralove (Czechoslovakia). Lekarska Fakulta
- Slovenska Akademia Vied, Bratislava (Czechoslovakia). Ustav Experimentalnej Farmakologie
- Medical Academy J.E. Purkyne, Hradec Kralove (Czechoslovakia)
Citation Formats
Trnovec, T, Kallay, Z, Volenec, K, Bezek, S, Durisova, M, Scasnar, V, Kubu, M, and Svoboda, V.
The effect of high energy electron irradiation on blood-brain barrier permeability to haloperidol and stobadin in rats.
Germany: N. p.,
1991.
Web.
doi:10.1007/BF01210512.
Trnovec, T, Kallay, Z, Volenec, K, Bezek, S, Durisova, M, Scasnar, V, Kubu, M, & Svoboda, V.
The effect of high energy electron irradiation on blood-brain barrier permeability to haloperidol and stobadin in rats.
Germany.
https://doi.org/10.1007/BF01210512
Trnovec, T, Kallay, Z, Volenec, K, Bezek, S, Durisova, M, Scasnar, V, Kubu, M, and Svoboda, V.
1991.
"The effect of high energy electron irradiation on blood-brain barrier permeability to haloperidol and stobadin in rats."
Germany.
https://doi.org/10.1007/BF01210512.
@misc{etde_5315018,
title = {The effect of high energy electron irradiation on blood-brain barrier permeability to haloperidol and stobadin in rats}
author = {Trnovec, T, Kallay, Z, Volenec, K, Bezek, S, Durisova, M, Scasnar, V, Kubu, M, and Svoboda, V}
abstractNote = {The heads of rats were irradiated by 4 MeV electrons in doses 90, 180, and 360 Gy. The observed times of deaths ranged 120-600, 60-420, and 150-370 min after 90, 180, and 360 Gy, respectively. A dose dependent decrease of the brain uptake index of haloperidol was observed 1 and 3 h post radiation. On the other hand an increased brain uptake index was found for stobadin after head irradiation with doses of 180 and 360 Gy. Regional cerebral blood flow, blood pressure, and heart rate were not significantly altered in the period following irradiation with 180 Gy. The observed changes in blood-brain barrier (BBB) permeability seem to be the result of the damaged function of morphological structures forming the BBB rather than altered regional blood flow. (orig.).}
doi = {10.1007/BF01210512}
journal = []
volume = {30:4}
journal type = {AC}
place = {Germany}
year = {1991}
month = {Oct}
}
title = {The effect of high energy electron irradiation on blood-brain barrier permeability to haloperidol and stobadin in rats}
author = {Trnovec, T, Kallay, Z, Volenec, K, Bezek, S, Durisova, M, Scasnar, V, Kubu, M, and Svoboda, V}
abstractNote = {The heads of rats were irradiated by 4 MeV electrons in doses 90, 180, and 360 Gy. The observed times of deaths ranged 120-600, 60-420, and 150-370 min after 90, 180, and 360 Gy, respectively. A dose dependent decrease of the brain uptake index of haloperidol was observed 1 and 3 h post radiation. On the other hand an increased brain uptake index was found for stobadin after head irradiation with doses of 180 and 360 Gy. Regional cerebral blood flow, blood pressure, and heart rate were not significantly altered in the period following irradiation with 180 Gy. The observed changes in blood-brain barrier (BBB) permeability seem to be the result of the damaged function of morphological structures forming the BBB rather than altered regional blood flow. (orig.).}
doi = {10.1007/BF01210512}
journal = []
volume = {30:4}
journal type = {AC}
place = {Germany}
year = {1991}
month = {Oct}
}