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Experimental alkylmercurial poisoning in swine. Lesions in the peripheral and central nervous systems

Journal Article:

Abstract

The effects of alkylmercurial poisoning were studied in 16 pigs poisoned with daily oral doses of a fungicide containing methylmercury 2, 3-dihydroxy propyl mercaptide and methylmercury acetate. Clinical signs included weakness, wobbling gait, blindness, recumbency and death. Microscopic studies of the peripheral nervous system revealed Wallerian degeneration in sensory fibers and neuronal degeneration in dorsal root ganglia. In the central nervous system, there were neuronal degeneration of ischemic type, glial degeneration, gliosis and necrosis of the media of meningeal arterioles. The last mentioned lesion was not extensive. The sequential development of lesions and the absence of segmental demyelination suggest that the primary lesion in the peripheral nervous system was neuronal-axonal degeneration rather than degeneration of the Schwann cell and myelin sheath. 25 references.
Authors:
Publication Date:
Jan 01, 1974
Product Type:
Journal Article
Reference Number:
EDB-85-150114
Resource Relation:
Journal Name: Can. J. Comp. Med.; (Canada); Journal Volume: 38:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MERCURY; BIOLOGICAL EFFECTS; ANIMAL TISSUES; CENTRAL NERVOUS SYSTEM; CEREALS; EXPERIMENTAL DATA; FUNGICIDES; HISTOLOGICAL TECHNIQUES; SWINE; ANIMALS; BODY; DATA; DOMESTIC ANIMALS; ELEMENTS; GRASS; INFORMATION; MAMMALS; METALS; NERVOUS SYSTEM; NUMERICAL DATA; PESTICIDES; PLANTS; TISSUES; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
5310136
Research Organizations:
Animal Diseases Research Institute, Hull, Quebec
Country of Origin:
Canada
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CJCMA
Submitting Site:
HEDB
Size:
Pages: 75-81
Announcement Date:

Journal Article:

Citation Formats

Charlton, K M. Experimental alkylmercurial poisoning in swine. Lesions in the peripheral and central nervous systems. Canada: N. p., 1974. Web.
Charlton, K M. Experimental alkylmercurial poisoning in swine. Lesions in the peripheral and central nervous systems. Canada.
Charlton, K M. 1974. "Experimental alkylmercurial poisoning in swine. Lesions in the peripheral and central nervous systems." Canada.
@misc{etde_5310136,
title = {Experimental alkylmercurial poisoning in swine. Lesions in the peripheral and central nervous systems}
author = {Charlton, K M}
abstractNote = {The effects of alkylmercurial poisoning were studied in 16 pigs poisoned with daily oral doses of a fungicide containing methylmercury 2, 3-dihydroxy propyl mercaptide and methylmercury acetate. Clinical signs included weakness, wobbling gait, blindness, recumbency and death. Microscopic studies of the peripheral nervous system revealed Wallerian degeneration in sensory fibers and neuronal degeneration in dorsal root ganglia. In the central nervous system, there were neuronal degeneration of ischemic type, glial degeneration, gliosis and necrosis of the media of meningeal arterioles. The last mentioned lesion was not extensive. The sequential development of lesions and the absence of segmental demyelination suggest that the primary lesion in the peripheral nervous system was neuronal-axonal degeneration rather than degeneration of the Schwann cell and myelin sheath. 25 references.}
journal = {Can. J. Comp. Med.; (Canada)}
volume = {38:1}
journal type = {AC}
place = {Canada}
year = {1974}
month = {Jan}
}