You need JavaScript to view this

Carbon-11 labeled diacylglycerol for signal transduction imaging by positron CT. Evaluation of the quality and safety for clinical use

Journal Article:

Abstract

To elucidate the synaptic transmission in the neural system, we have been developing fundamental studies for intracellular signaling. For clinical application of carbon-11 labeled diacylglycerol (1-[1-{sup 11}C]butyryl-2-palmitoyl-rac-glycerol: {sup 11}C-DAG) using positron emission computed tomography (PET), we evaluated the quality and the safety of {sup 11}C-DAG as the solution for injection. As a result, {sup 11}C-DAG was synthesized within 50 minutes, including the preparation step for injection. The half life time and energy spectrum of {sup 11}C-DAG were the same as the physical character of carbon-11, and other radioisotopes were not detected. In the quality control, {sup 11}C-DAG solution was negative in the examination of bacterial contamination and the pyrogen test in three successive synthesis procedures. In the acute toxicity test by administration of {sup 11}C-DAG and 100 {mu}mol/kg of non-radioactive DAG to the rat intravenously, the systemic condition of the rat was not changed and no abnormalities were found in any organ 24 hours after administration. These findings indicated the safety of {sup 11}C-DAG solution. Clinical application of {sup 11}C-DAG using positron emission tomography may be useful to elucidate the dysfunction of intracellular signaling in disorders of higher cortical function such as Alzheimer disease. (author).
Authors:
Fujii, Ryou; [1]  Imahori, Yoshio; Ido, Tatsuo [2] 
  1. Nishijin Hospital, Kyoto (Japan)
  2. and others
Publication Date:
Feb 01, 1995
Product Type:
Journal Article
Reference Number:
SCA: 550601; PA: JPN-95:004400; EDB-95:086997; SN: 95001401786
Resource Relation:
Journal Name: Kaku Igaku (Japanese Journal of Nuclear Medicine); Journal Volume: 32; Journal Issue: 2; Other Information: PBD: Feb 1995
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; CARBON 11; RADIOPHARMACEUTICALS; CARBOXYLIC ACIDS; POSITRON COMPUTED TOMOGRAPHY; SYNTHESIS; NERVE CELLS; ENERGY SPECTRA; TISSUE DISTRIBUTION; PH VALUE; RATS; TOXICITY; BIOLOGICAL HALF-LIFE; RADIATION DOSES
OSTI ID:
53088
Research Organizations:
No corporate text available (Country unknown/Code not available)
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: KAIGBZ; ISSN 0022-7854; TRN: JP9504400
Submitting Site:
JPN
Size:
pp. 191-198
Announcement Date:
Jun 19, 1995

Journal Article:

Citation Formats

Fujii, Ryou, Imahori, Yoshio, and Ido, Tatsuo. Carbon-11 labeled diacylglycerol for signal transduction imaging by positron CT. Evaluation of the quality and safety for clinical use. Japan: N. p., 1995. Web.
Fujii, Ryou, Imahori, Yoshio, & Ido, Tatsuo. Carbon-11 labeled diacylglycerol for signal transduction imaging by positron CT. Evaluation of the quality and safety for clinical use. Japan.
Fujii, Ryou, Imahori, Yoshio, and Ido, Tatsuo. 1995. "Carbon-11 labeled diacylglycerol for signal transduction imaging by positron CT. Evaluation of the quality and safety for clinical use." Japan.
@misc{etde_53088,
title = {Carbon-11 labeled diacylglycerol for signal transduction imaging by positron CT. Evaluation of the quality and safety for clinical use}
author = {Fujii, Ryou, Imahori, Yoshio, and Ido, Tatsuo}
abstractNote = {To elucidate the synaptic transmission in the neural system, we have been developing fundamental studies for intracellular signaling. For clinical application of carbon-11 labeled diacylglycerol (1-[1-{sup 11}C]butyryl-2-palmitoyl-rac-glycerol: {sup 11}C-DAG) using positron emission computed tomography (PET), we evaluated the quality and the safety of {sup 11}C-DAG as the solution for injection. As a result, {sup 11}C-DAG was synthesized within 50 minutes, including the preparation step for injection. The half life time and energy spectrum of {sup 11}C-DAG were the same as the physical character of carbon-11, and other radioisotopes were not detected. In the quality control, {sup 11}C-DAG solution was negative in the examination of bacterial contamination and the pyrogen test in three successive synthesis procedures. In the acute toxicity test by administration of {sup 11}C-DAG and 100 {mu}mol/kg of non-radioactive DAG to the rat intravenously, the systemic condition of the rat was not changed and no abnormalities were found in any organ 24 hours after administration. These findings indicated the safety of {sup 11}C-DAG solution. Clinical application of {sup 11}C-DAG using positron emission tomography may be useful to elucidate the dysfunction of intracellular signaling in disorders of higher cortical function such as Alzheimer disease. (author).}
journal = {Kaku Igaku (Japanese Journal of Nuclear Medicine)}
issue = {2}
volume = {32}
journal type = {AC}
place = {Japan}
year = {1995}
month = {Feb}
}