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Method of monolayer cultures of the guinea pig spleen used to evaluate the radioprotective action of mexamine on the survival of colony-forming cells. [Method of monolayer cultures, quantitative estimation of radioprotective action of drugs]

Journal Article:

Abstract

Dose dependent survival of colony-forming splenic cells of guinea pigs has been studied after ..gamma..-irradiation in vitro. The average lethal dose (D/sub 0/) for colony-forming cells is 245 rads, the extrapolation number - 1.5. Radiosensitivity of the splenic cells is markedly lower than that of the bone marrow cells (128 rads). After intraperitoneal administration of mexamine (150 mg/kg) to guinea pigs 10-15 min before irradiation, D/sub 0/ increases up to 319 rads, extrapolation number is 1.4, and DRF is 1.3.
Authors:
Baisogolov, G D; Rudakova, S F; Rudakov, I A; Konoplyannikov, A G [1] 
  1. Akademiya Meditsinskikh Nauk SSSR, Obninsk. Nauchno-Issledovatel'skij Inst. Meditsinskoj Radiologii
Publication Date:
Jan 01, 1976
Product Type:
Journal Article
Reference Number:
AIX-09-360218; EDB-78-046878
Resource Relation:
Journal Name: Radiobiologiya; (USSR); Journal Volume: 16:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BONE MARROW CELLS; RADIOPROTECTIVE SUBSTANCES; GAMMA RADIATION; BIOLOGICAL RADIATION EFFECTS; MEXAMINE; RESPONSE MODIFYING FACTORS; CFU; DOSE-RESPONSE RELATIONSHIPS; EFFICIENCY; GUINEA PIGS; IN VITRO; LETHAL IRRADIATION; ORGANIC OXYGEN COMPOUNDS; SURVIVAL CURVES; SUSPENSIONS; AMINES; ANIMAL CELLS; ANIMALS; AZOLES; BIOLOGICAL EFFECTS; CONNECTIVE TISSUE CELLS; DISPERSIONS; DRUGS; ELECTROMAGNETIC RADIATION; ETHERS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INDOLES; IONIZING RADIATIONS; IRRADIATION; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRROLES; RADIATION EFFECTS; RADIATIONS; RODENTS; SEROTONIN; SOMATIC CELLS; SYMPATHOMIMETICS; TRYPTAMINES; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals; 560122 - Radiation Effects on Cells- Internal Source- (-1987)
OSTI ID:
5302368
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: RADOA
Submitting Site:
INIS
Size:
Pages: 117-120
Announcement Date:

Journal Article:

Citation Formats

Baisogolov, G D, Rudakova, S F, Rudakov, I A, and Konoplyannikov, A G. Method of monolayer cultures of the guinea pig spleen used to evaluate the radioprotective action of mexamine on the survival of colony-forming cells. [Method of monolayer cultures, quantitative estimation of radioprotective action of drugs]. USSR: N. p., 1976. Web.
Baisogolov, G D, Rudakova, S F, Rudakov, I A, & Konoplyannikov, A G. Method of monolayer cultures of the guinea pig spleen used to evaluate the radioprotective action of mexamine on the survival of colony-forming cells. [Method of monolayer cultures, quantitative estimation of radioprotective action of drugs]. USSR.
Baisogolov, G D, Rudakova, S F, Rudakov, I A, and Konoplyannikov, A G. 1976. "Method of monolayer cultures of the guinea pig spleen used to evaluate the radioprotective action of mexamine on the survival of colony-forming cells. [Method of monolayer cultures, quantitative estimation of radioprotective action of drugs]." USSR.
@misc{etde_5302368,
title = {Method of monolayer cultures of the guinea pig spleen used to evaluate the radioprotective action of mexamine on the survival of colony-forming cells. [Method of monolayer cultures, quantitative estimation of radioprotective action of drugs]}
author = {Baisogolov, G D, Rudakova, S F, Rudakov, I A, and Konoplyannikov, A G}
abstractNote = {Dose dependent survival of colony-forming splenic cells of guinea pigs has been studied after ..gamma..-irradiation in vitro. The average lethal dose (D/sub 0/) for colony-forming cells is 245 rads, the extrapolation number - 1.5. Radiosensitivity of the splenic cells is markedly lower than that of the bone marrow cells (128 rads). After intraperitoneal administration of mexamine (150 mg/kg) to guinea pigs 10-15 min before irradiation, D/sub 0/ increases up to 319 rads, extrapolation number is 1.4, and DRF is 1.3.}
journal = {Radiobiologiya; (USSR)}
volume = {16:1}
journal type = {AC}
place = {USSR}
year = {1976}
month = {Jan}
}