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Vascular pattern of the spontaneous C3H mouse mammary carcinoma and its significance in radiation response and in hyperthermia

Journal Article:

Abstract

This study showed that the vascular pattern of the spontaneous C3H mouse mammary carcinoma develops from a capillary network into an afferent system lacking arterioles and consisting only of capillary-like vessels and an efferent system characterized by large sinuses. Lack of correlation between the growth of stroma and parenchyma leads to a circuitous and uneven supply of blood and to a high degree of occlusion of the efferent system with consequent reduction in the rate of flow of blood. The parenchyma consists of tubules formed of single or multiple layers of cells between which capillaries do not penetrate. The diffusion pathway of oxygen and nutrients to the inner cells of the multi-layered tubules is considerably longer than that to their outer cells or to the cells of the single-layered tubules. Consequently it is in the former parts that anoxia and severe hypoxia are likely to prevail. The pattern of necrosis agrees with this supposition. It is predicted that radiation hyperthermia will act differentially and in opposite senses on these two tumour components, hyperthermia being more effective on the former, radiation on the latter.
Authors:
Falk, P [1] 
  1. Hammersmith Hospital, London (UK). M.R.C. Cyclotron Unit
Publication Date:
Feb 01, 1980
Product Type:
Journal Article
Reference Number:
AIX-11-538001; EDB-80-098461
Resource Relation:
Journal Name: Eur. J. Cancer; (United Kingdom); Journal Volume: 16:2
Subject:
59 BASIC BIOLOGICAL SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; BLOOD CIRCULATION; MAMMARY GLANDS; ANOXIA; ARTERIES; BIOLOGICAL RADIATION EFFECTS; CAPILLARIES; HEAT TREATMENTS; HISTOLOGY; MICE; NECROSIS; TISSUES; VEINS; X RADIATION; ANIMALS; BIOLOGICAL EFFECTS; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; DISEASES; ELECTROMAGNETIC RADIATION; GLANDS; IONIZING RADIATIONS; MAMMALS; NEOPLASMS; ORGANS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES; 550900* - Pathology; 550603 - Medicine- External Radiation in Therapy- (1980-)
OSTI ID:
5300778
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EJCAA
Submitting Site:
INIS
Size:
Pages: 203-217
Announcement Date:

Journal Article:

Citation Formats

Falk, P. Vascular pattern of the spontaneous C3H mouse mammary carcinoma and its significance in radiation response and in hyperthermia. United Kingdom: N. p., 1980. Web.
Falk, P. Vascular pattern of the spontaneous C3H mouse mammary carcinoma and its significance in radiation response and in hyperthermia. United Kingdom.
Falk, P. 1980. "Vascular pattern of the spontaneous C3H mouse mammary carcinoma and its significance in radiation response and in hyperthermia." United Kingdom.
@misc{etde_5300778,
title = {Vascular pattern of the spontaneous C3H mouse mammary carcinoma and its significance in radiation response and in hyperthermia}
author = {Falk, P}
abstractNote = {This study showed that the vascular pattern of the spontaneous C3H mouse mammary carcinoma develops from a capillary network into an afferent system lacking arterioles and consisting only of capillary-like vessels and an efferent system characterized by large sinuses. Lack of correlation between the growth of stroma and parenchyma leads to a circuitous and uneven supply of blood and to a high degree of occlusion of the efferent system with consequent reduction in the rate of flow of blood. The parenchyma consists of tubules formed of single or multiple layers of cells between which capillaries do not penetrate. The diffusion pathway of oxygen and nutrients to the inner cells of the multi-layered tubules is considerably longer than that to their outer cells or to the cells of the single-layered tubules. Consequently it is in the former parts that anoxia and severe hypoxia are likely to prevail. The pattern of necrosis agrees with this supposition. It is predicted that radiation hyperthermia will act differentially and in opposite senses on these two tumour components, hyperthermia being more effective on the former, radiation on the latter.}
journal = {Eur. J. Cancer; (United Kingdom)}
volume = {16:2}
journal type = {AC}
place = {United Kingdom}
year = {1980}
month = {Feb}
}