You need JavaScript to view this

Anti-glucagon antibodies in diabetes mellitus

Journal Article:

Abstract

Anti-insulin antibodies appear in the sera of patients treated with insulin lastingly. A high anti-insulin antibody level results in the development of insulin resistance. Most of the insulin preparations available on the market contain also glucagon as an impurity. It was therefore to be expected that in part of the patients, who had been treated with insulin lastingly, antibodies would be produced also against glucagon, and the presence of these was actually demonstrated. It is to be assumed that the anti-glucagon antibodies play a role in the pathomechanism of diabetes mellitus, mainly in its labile form. The possible presence of anti-glucagon antibodies must be taken into account when the glucagon concentration in the sera of diabetics is to be determined by means of radioimmunoassay (RIA). The specific antibodies in the serum give false results in the quantitative determination of glucagon. We have tested the sera of 10 diabetics who had been treated with insulin for at least 6 years. All patients were given protamine zinc and crystalline insulin preparations.
Publication Date:
Jan 01, 1973
Product Type:
Journal Article
Reference Number:
EDB-78-034020
Resource Relation:
Journal Name: Ann. Immunol. Hung.; (Hungary); Journal Volume: 17
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; GLUCAGON; RADIOIMMUNOASSAY; ERRORS; ANTIBODIES; BLOOD SERUM; DIABETES MELLITUS; IODINE 125; PATIENTS; BETA DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; ENDOCRINE DISEASES; HORMONES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PEPTIDE HORMONES; PEPTIDES; POLYPEPTIDES; PROTEINS; RADIOASSAY; RADIOISOTOPES; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5300733
Research Organizations:
Inst. for Serobacteriological Production and Research, Budapest
Country of Origin:
Hungary
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: AIMHA
Submitting Site:
TIC
Size:
Pages: 231-233
Announcement Date:

Journal Article:

Citation Formats

Gergely, A, Koranyi, L, Halmos, T, Zsombok, M, Peterfy, F, Csizer, Z, Salamon, F, and Tako, J. Anti-glucagon antibodies in diabetes mellitus. Hungary: N. p., 1973. Web.
Gergely, A, Koranyi, L, Halmos, T, Zsombok, M, Peterfy, F, Csizer, Z, Salamon, F, & Tako, J. Anti-glucagon antibodies in diabetes mellitus. Hungary.
Gergely, A, Koranyi, L, Halmos, T, Zsombok, M, Peterfy, F, Csizer, Z, Salamon, F, and Tako, J. 1973. "Anti-glucagon antibodies in diabetes mellitus." Hungary.
@misc{etde_5300733,
title = {Anti-glucagon antibodies in diabetes mellitus}
author = {Gergely, A, Koranyi, L, Halmos, T, Zsombok, M, Peterfy, F, Csizer, Z, Salamon, F, and Tako, J}
abstractNote = {Anti-insulin antibodies appear in the sera of patients treated with insulin lastingly. A high anti-insulin antibody level results in the development of insulin resistance. Most of the insulin preparations available on the market contain also glucagon as an impurity. It was therefore to be expected that in part of the patients, who had been treated with insulin lastingly, antibodies would be produced also against glucagon, and the presence of these was actually demonstrated. It is to be assumed that the anti-glucagon antibodies play a role in the pathomechanism of diabetes mellitus, mainly in its labile form. The possible presence of anti-glucagon antibodies must be taken into account when the glucagon concentration in the sera of diabetics is to be determined by means of radioimmunoassay (RIA). The specific antibodies in the serum give false results in the quantitative determination of glucagon. We have tested the sera of 10 diabetics who had been treated with insulin for at least 6 years. All patients were given protamine zinc and crystalline insulin preparations.}
journal = {Ann. Immunol. Hung.; (Hungary)}
volume = {17}
journal type = {AC}
place = {Hungary}
year = {1973}
month = {Jan}
}