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Clinico-chemical studies on subacute cadmium poisoning in rabbits

Journal Article:

Abstract

GOT, GPT, LDH, total Ac-P, prostatic Ac-P, cholesterol, free fatty acid, Ca, and P in plasma were measured once a week on rabbits injected subcutaneously with 0.5 and 1.0 mg Cd/kg daily for 11 weeks respectively, and Cd, Cu, Mn, and Zn contents in organs were determined at the termination of the experiment. Prostatic Ac-P activity, cholesterol, and free fatty acid levels in plasma rose in the early stage of administration, and GOT, GPT, LDH, and Al-P activities rose in the latter stage of administration. Ca and P levels in plasma did not change in any periods of the experiment. From these results, it could be concluded that a measurement of prostatic Ac-P, cholesterol, and free fatty acid is adequate to evaluate excess intake of Cd. Cd contents in heart, lungs, spleen, and testes of rabbits injected with 1.0 mg Cd/kg increased significantly compared with those with 0.5 mg Cd/kg, but a difference between the two groups in Cd contents in liver, kidneys and submandibular glands which contained high concentration of Cd was not recognized. Zn contents in organs of rabbits injected with Cd increased remarkably, while Cu contents decreased generally. This phenomenon was especially remarkable in liver and kidneys.  More>>
Publication Date:
Jan 01, 1974
Product Type:
Journal Article
Reference Number:
EDB-85-142578
Resource Relation:
Journal Name: Ind. Health (Kawasaki, Jpn.); (Japan); Journal Volume: 12:3-4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CADMIUM; SUBCUTANEOUS INJECTION; TOXICITY; BIOLOGICAL LOCALIZATION; BLOOD PLASMA; CALCIUM; CARBOXYLIC ACIDS; CHEMICAL COMPOSITION; CHOLESTEROL; CHRONIC EXPOSURE; ENZYMES; HEART; KIDNEYS; LIVER; LUNGS; PHOSPHORUS; RABBITS; SPLEEN; TESTES; TISSUE DISTRIBUTION; ZINC; ALKALINE EARTH METALS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BODY; BODY FLUIDS; CARDIOVASCULAR SYSTEM; DIGESTIVE SYSTEM; DISTRIBUTION; ELEMENTS; GLANDS; GONADS; HYDROXY COMPOUNDS; INJECTION; INTAKE; MALE GENITALS; MAMMALS; MATERIALS; METALS; NONMETALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RESPIRATORY SYSTEM; STEROIDS; STEROLS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
5300203
Research Organizations:
National Institute of Industrial Health, Kawasaki, Japan
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: INHEA
Submitting Site:
HEDB
Size:
Pages: 127-140
Announcement Date:

Journal Article:

Citation Formats

Yoshikawa, H, Ohsawa, M, and Kaneta, M. Clinico-chemical studies on subacute cadmium poisoning in rabbits. Japan: N. p., 1974. Web.
Yoshikawa, H, Ohsawa, M, & Kaneta, M. Clinico-chemical studies on subacute cadmium poisoning in rabbits. Japan.
Yoshikawa, H, Ohsawa, M, and Kaneta, M. 1974. "Clinico-chemical studies on subacute cadmium poisoning in rabbits." Japan.
@misc{etde_5300203,
title = {Clinico-chemical studies on subacute cadmium poisoning in rabbits}
author = {Yoshikawa, H, Ohsawa, M, and Kaneta, M}
abstractNote = {GOT, GPT, LDH, total Ac-P, prostatic Ac-P, cholesterol, free fatty acid, Ca, and P in plasma were measured once a week on rabbits injected subcutaneously with 0.5 and 1.0 mg Cd/kg daily for 11 weeks respectively, and Cd, Cu, Mn, and Zn contents in organs were determined at the termination of the experiment. Prostatic Ac-P activity, cholesterol, and free fatty acid levels in plasma rose in the early stage of administration, and GOT, GPT, LDH, and Al-P activities rose in the latter stage of administration. Ca and P levels in plasma did not change in any periods of the experiment. From these results, it could be concluded that a measurement of prostatic Ac-P, cholesterol, and free fatty acid is adequate to evaluate excess intake of Cd. Cd contents in heart, lungs, spleen, and testes of rabbits injected with 1.0 mg Cd/kg increased significantly compared with those with 0.5 mg Cd/kg, but a difference between the two groups in Cd contents in liver, kidneys and submandibular glands which contained high concentration of Cd was not recognized. Zn contents in organs of rabbits injected with Cd increased remarkably, while Cu contents decreased generally. This phenomenon was especially remarkable in liver and kidneys. 31 references, 7 figures, 2 tables.}
journal = {Ind. Health (Kawasaki, Jpn.); (Japan)}
volume = {12:3-4}
journal type = {AC}
place = {Japan}
year = {1974}
month = {Jan}
}