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Chronic copper poisoning in lambs

Journal Article:

Abstract

This communication presented evidence of the elevation of plasma GOT (glutamic oxaloacetic transaminase or aspartate transaminase) concentration during the development of copper toxicity in some experimental lambs, and also demonstrated that plasma GOT concentration can be used to assess the course of the disease during treatment. A group of Kerry Hill lambs were fed 1 1/2 lb per day of a proprietary concentrate containing 40 parts of copper per million on a dry-matter basis in addition to hay and water ad lib. Data was included for the plasma GOT concentrations of the lambs, bled weekly after weaning from pasture to this diet. There was some variation between the individual lambs, and in one there was no increase in plasma GOT by the 20th week when all the surviving lambs were slaughtered. The concentrations of copper found in the caudate lobe of the liver and in the kidney cortex post mortem were given. The overall findings showed that the liver gave a reliable indication of the copper status of an animal whereas the kidney cortex copper concentration was a better criterion for the diagnosis of copper poisoning and was in agreement with the results of Eden, Todd, and Grocey and Thompson.  More>>
Authors:
Publication Date:
Aug 08, 1964
Product Type:
Journal Article
Reference Number:
EDB-85-142590
Resource Relation:
Journal Name: Vet. Rec.; (United Kingdom); Journal Volume: 76:32
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; COPPER; TOXICITY; AMINOTRANSFERASES; AMMONIUM COMPOUNDS; DIET; ECOLOGICAL CONCENTRATION; EXPERIMENTAL DATA; GLUTAMIC ACID; KIDNEYS; LIVER; MOLYBDATES; RESPONSE MODIFYING FACTORS; SHEEP; SODIUM SULFATES; UNITED KINGDOM; ALKALI METAL COMPOUNDS; AMINO ACIDS; ANIMALS; BODY; CARBOXYLIC ACIDS; DATA; DIGESTIVE SYSTEM; DOMESTIC ANIMALS; ELEMENTS; ENZYMES; EUROPE; GLANDS; INFORMATION; MAMMALS; METALS; MOLYBDENUM COMPOUNDS; NITROGEN TRANSFERASES; NUMERICAL DATA; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; REFRACTORY METAL COMPOUNDS; RUMINANTS; SODIUM COMPOUNDS; SULFATES; SULFUR COMPOUNDS; TRANSFERASES; TRANSITION ELEMENT COMPOUNDS; TRANSITION ELEMENTS; VERTEBRATES; WESTERN EUROPE; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
5300137
Research Organizations:
Farm Livestock Research Centre, Stock, England
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: VETRA
Submitting Site:
HEDB
Size:
Pages: 875-876
Announcement Date:

Journal Article:

Citation Formats

Ross, D B. Chronic copper poisoning in lambs. United Kingdom: N. p., 1964. Web.
Ross, D B. Chronic copper poisoning in lambs. United Kingdom.
Ross, D B. 1964. "Chronic copper poisoning in lambs." United Kingdom.
@misc{etde_5300137,
title = {Chronic copper poisoning in lambs}
author = {Ross, D B}
abstractNote = {This communication presented evidence of the elevation of plasma GOT (glutamic oxaloacetic transaminase or aspartate transaminase) concentration during the development of copper toxicity in some experimental lambs, and also demonstrated that plasma GOT concentration can be used to assess the course of the disease during treatment. A group of Kerry Hill lambs were fed 1 1/2 lb per day of a proprietary concentrate containing 40 parts of copper per million on a dry-matter basis in addition to hay and water ad lib. Data was included for the plasma GOT concentrations of the lambs, bled weekly after weaning from pasture to this diet. There was some variation between the individual lambs, and in one there was no increase in plasma GOT by the 20th week when all the surviving lambs were slaughtered. The concentrations of copper found in the caudate lobe of the liver and in the kidney cortex post mortem were given. The overall findings showed that the liver gave a reliable indication of the copper status of an animal whereas the kidney cortex copper concentration was a better criterion for the diagnosis of copper poisoning and was in agreement with the results of Eden, Todd, and Grocey and Thompson. Observations demonstrated the benefits resulting from the early diagnosis of chronic copper poisoning in lambs, when treatment of affected animals may be commenced before the haemolytic crisis develops. Treatment included reducing the copper intake and dosing with ammonium molybdate and sodium sulfate, and the plasma GOT concentration may be used to assess the rate of recovery. 4 references, 3 tables.}
journal = {Vet. Rec.; (United Kingdom)}
volume = {76:32}
journal type = {AC}
place = {United Kingdom}
year = {1964}
month = {Aug}
}