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Lack of radiation protective effect of orgotein in normal and malignant mammalian cells

Journal Article:

Abstract

The potential radiation protective effect of orgotein, a metalloprotein with superoxide dismutase activity, was investigated in L/sub 1/A/sub 2/ tumour cells in vitro, jejunal crypt cells and C/sub 3/H mouse mammary carcinoma in vivo. No effect of orgotein, given either 2 hours before irradiation or 30 min after, was observed compared to the effect of irradiation alone. Thus, it was concluded that orgotein did not influence the primary radiation response in air in mammalian cells.
Authors:
Overgaard, J; Nielsen, O S; Overgaard, M; Steenholdt, S; Jakobsen, A; Sell, A [1] 
  1. Institute of Cancer Research and The Department of Radiation Therapy and Oncology, The Radium Centre, Aarhus, Denmark
Publication Date:
Jan 01, 1979
Product Type:
Journal Article
Reference Number:
AIX-11-525154; EDB-80-086405
Resource Relation:
Journal Name: Acta Radiol.: Oncol., Radiat Phys., Biol.; (Sweden); Journal Volume: 18:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HYPERTHERMIA; RADIOSENSITIVITY EFFECTS; PROTEINS; TISSUE EXTRACTS; CARCINOMAS; CRYPT CELLS; DOSE-RESPONSE RELATIONSHIPS; EXPERIMENTAL DATA; FERMENTATION; GRAPHS; IRRADIATION; MAMMARY GLANDS; MICE; RADIATION DOSES; RADIOPROTECTIVE SUBSTANCES; SMALL INTESTINE; SUPEROXIDE RADICALS; SURVIVAL CURVES; TUMOR CELLS; ANIMAL CELLS; ANIMALS; BIOCONVERSION; BIOLOGICAL MATERIALS; BODY; BODY TEMPERATURE; DATA; DATA FORMS; DIGESTIVE SYSTEM; DISEASES; DOSES; DRUGS; GASTROINTESTINAL TRACT; GLANDS; INFORMATION; INTESTINES; MAMMALS; MATERIALS; NEOPLASMS; NUMERICAL DATA; ORGANIC COMPOUNDS; ORGANS; RADICALS; RESPONSE MODIFYING FACTORS; RODENTS; SOMATIC CELLS; TISSUES; VERTEBRATES; 560121* - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
5299039
Country of Origin:
Sweden
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: AROND
Submitting Site:
INIS
Size:
Pages: 305-312
Announcement Date:
Jun 01, 1980

Journal Article:

Citation Formats

Overgaard, J, Nielsen, O S, Overgaard, M, Steenholdt, S, Jakobsen, A, and Sell, A. Lack of radiation protective effect of orgotein in normal and malignant mammalian cells. Sweden: N. p., 1979. Web.
Overgaard, J, Nielsen, O S, Overgaard, M, Steenholdt, S, Jakobsen, A, & Sell, A. Lack of radiation protective effect of orgotein in normal and malignant mammalian cells. Sweden.
Overgaard, J, Nielsen, O S, Overgaard, M, Steenholdt, S, Jakobsen, A, and Sell, A. 1979. "Lack of radiation protective effect of orgotein in normal and malignant mammalian cells." Sweden.
@misc{etde_5299039,
title = {Lack of radiation protective effect of orgotein in normal and malignant mammalian cells}
author = {Overgaard, J, Nielsen, O S, Overgaard, M, Steenholdt, S, Jakobsen, A, and Sell, A}
abstractNote = {The potential radiation protective effect of orgotein, a metalloprotein with superoxide dismutase activity, was investigated in L/sub 1/A/sub 2/ tumour cells in vitro, jejunal crypt cells and C/sub 3/H mouse mammary carcinoma in vivo. No effect of orgotein, given either 2 hours before irradiation or 30 min after, was observed compared to the effect of irradiation alone. Thus, it was concluded that orgotein did not influence the primary radiation response in air in mammalian cells.}
journal = {Acta Radiol.: Oncol., Radiat Phys., Biol.; (Sweden)}
volume = {18:4}
journal type = {AC}
place = {Sweden}
year = {1979}
month = {Jan}
}