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Glucocorticoid receptors on leukemic cells as evidenced by dexamethasone-induced cytolysis and /sup 3/H-dexamethasone binding

Journal Article:

Abstract

The presence of glucocorticoid receptors on the leukemic cells of 33 patients affected with acute lymphatic leukemia (ALL) and 6 patients affected with acute myeloic leukemia (AML) was investigated by dexamethasone-induced cytolysis and (/sup 3/H)-dexamethasone binding. The tests undertaken proved that after 20 hours of incubation 9 of 26 non-T-non-B-ALL (c-ALL and unclassified ALL) and 2 of AML were lysed with dexamethasone; blood lymphocytes and bone marrow leukocytes of healthy donors, however, were not affected. Non-T-non-B-ALL and AML were able to bind essentially more (/sup 3/H)-dexamethasone than T-ALL. There existed no correlation between dexamethasone binding and dexamethasone-induced cytolysis.
Publication Date:
Jan 01, 1987
Product Type:
Journal Article
Reference Number:
AIX-19-054864; EDB-88-094607
Resource Relation:
Journal Name: Folia Haematol. (Leipzig); (German Democratic Republic); Journal Volume: 114:6
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DEXAMETHASONE; TRITIUM COMPOUNDS; GLUCOCORTICOIDS; RECEPTORS; BONE MARROW CELLS; LEUKEMIA; LYMPHOCYTES; MYELOID LEUKEMIA; PATIENTS; TRACER TECHNIQUES; ADRENAL HORMONES; ANIMAL CELLS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; CORTICOSTEROIDS; DISEASES; HEMIC DISEASES; HORMONES; HYDROXY COMPOUNDS; ISOTOPE APPLICATIONS; KETONES; LABELLED COMPOUNDS; LEUKOCYTES; MATERIALS; MEMBRANE PROTEINS; NEOPLASMS; ORGANIC COMPOUNDS; PREGNANES; PROTEINS; SOMATIC CELLS; STEROID HORMONES; STEROIDS; 560161* - Radionuclide Effects, Kinetics, & Toxicology- Man
OSTI ID:
5286887
Research Organizations:
Friedrich-Schiller-Universitaet, Jena (German Democratic Republic). Kinderklinik
Country of Origin:
Germany
Language:
German
Other Identifying Numbers:
Journal ID: CODEN: FOLHA
Submitting Site:
INIS
Size:
Pages: 751-759
Announcement Date:

Journal Article:

Citation Formats

Thraenhardt, H, Haefer, R, and Zintl, F. Glucocorticoid receptors on leukemic cells as evidenced by dexamethasone-induced cytolysis and /sup 3/H-dexamethasone binding. Germany: N. p., 1987. Web.
Thraenhardt, H, Haefer, R, & Zintl, F. Glucocorticoid receptors on leukemic cells as evidenced by dexamethasone-induced cytolysis and /sup 3/H-dexamethasone binding. Germany.
Thraenhardt, H, Haefer, R, and Zintl, F. 1987. "Glucocorticoid receptors on leukemic cells as evidenced by dexamethasone-induced cytolysis and /sup 3/H-dexamethasone binding." Germany.
@misc{etde_5286887,
title = {Glucocorticoid receptors on leukemic cells as evidenced by dexamethasone-induced cytolysis and /sup 3/H-dexamethasone binding}
author = {Thraenhardt, H, Haefer, R, and Zintl, F}
abstractNote = {The presence of glucocorticoid receptors on the leukemic cells of 33 patients affected with acute lymphatic leukemia (ALL) and 6 patients affected with acute myeloic leukemia (AML) was investigated by dexamethasone-induced cytolysis and (/sup 3/H)-dexamethasone binding. The tests undertaken proved that after 20 hours of incubation 9 of 26 non-T-non-B-ALL (c-ALL and unclassified ALL) and 2 of AML were lysed with dexamethasone; blood lymphocytes and bone marrow leukocytes of healthy donors, however, were not affected. Non-T-non-B-ALL and AML were able to bind essentially more (/sup 3/H)-dexamethasone than T-ALL. There existed no correlation between dexamethasone binding and dexamethasone-induced cytolysis.}
journal = {Folia Haematol. (Leipzig); (German Democratic Republic)}
volume = {114:6}
journal type = {AC}
place = {Germany}
year = {1987}
month = {Jan}
}