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Somatostatin and serum gastrin in normal subjects and in patients with pernicious anaemia, chronic liver and renal disease

Journal Article:

Abstract

The effects of somatostatin (growth hormone release inhibiting hormone) on basal gastrin were studied in patients suffering from pernicious anaemia and chronic renal and liver disease, and during sequential arginine/insulin-stimulated gastrin release in normal subjects. When basal gastrin concentrations were normal (10-50 pg/ml) in controls and in patients who were in renal and liver failure, somatostatin had no effect on gastrin levels. Raised basal gastrin levels in pernicious anaemia and in 2 cases of chronic renal disease, were significantly inhibited by somatostatin with a half-life (T-half) of 3 to 4 minutes. Arginine infusion caused an insignificant rise in serum gastrin which was unaffected by somatostatin, whereas insulin hypoglycaemia significantly stimulated gastrin release, which was inhibited by somatostatin.
Publication Date:
Sep 13, 1975
Product Type:
Journal Article
Reference Number:
AIX-08-330547; EDB-78-028537
Resource Relation:
Journal Name: S. Afr. Med. J.; (South Africa); Journal Volume: 49:39
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; GASTRIN; RADIOIMMUNOASSAY; HORMONES; ARGININE; BLOOD SERUM; DIALYSIS; INSULIN; IODINE 125; KIDNEYS; LIVER; PANCREAS; POLYPEPTIDES; STH; AMINO ACIDS; BETA DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; ELECTRON CAPTURE RADIOISOTOPES; ENDOCRINE GLANDS; GLANDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PEPTIDES; PITUITARY HORMONES; PROTEINS; RADIOASSAY; RADIOISOTOPES; SEPARATION PROCESSES; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5281552
Country of Origin:
South Africa
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: SAMJA
Submitting Site:
INIS
Size:
Pages: 1601-1604
Announcement Date:

Journal Article:

Citation Formats

Le Roith, D, Vinik, A I, Epstein, S, Baron, P, Olkenitzky, M N, and Pimstone, B L. Somatostatin and serum gastrin in normal subjects and in patients with pernicious anaemia, chronic liver and renal disease. South Africa: N. p., 1975. Web.
Le Roith, D, Vinik, A I, Epstein, S, Baron, P, Olkenitzky, M N, & Pimstone, B L. Somatostatin and serum gastrin in normal subjects and in patients with pernicious anaemia, chronic liver and renal disease. South Africa.
Le Roith, D, Vinik, A I, Epstein, S, Baron, P, Olkenitzky, M N, and Pimstone, B L. 1975. "Somatostatin and serum gastrin in normal subjects and in patients with pernicious anaemia, chronic liver and renal disease." South Africa.
@misc{etde_5281552,
title = {Somatostatin and serum gastrin in normal subjects and in patients with pernicious anaemia, chronic liver and renal disease}
author = {Le Roith, D, Vinik, A I, Epstein, S, Baron, P, Olkenitzky, M N, and Pimstone, B L}
abstractNote = {The effects of somatostatin (growth hormone release inhibiting hormone) on basal gastrin were studied in patients suffering from pernicious anaemia and chronic renal and liver disease, and during sequential arginine/insulin-stimulated gastrin release in normal subjects. When basal gastrin concentrations were normal (10-50 pg/ml) in controls and in patients who were in renal and liver failure, somatostatin had no effect on gastrin levels. Raised basal gastrin levels in pernicious anaemia and in 2 cases of chronic renal disease, were significantly inhibited by somatostatin with a half-life (T-half) of 3 to 4 minutes. Arginine infusion caused an insignificant rise in serum gastrin which was unaffected by somatostatin, whereas insulin hypoglycaemia significantly stimulated gastrin release, which was inhibited by somatostatin.}
journal = {S. Afr. Med. J.; (South Africa)}
volume = {49:39}
journal type = {AC}
place = {South Africa}
year = {1975}
month = {Sep}
}