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Decrease of glucose-induced insulin secretion of pancreatic rat islets after irradiation in vitro

Abstract

Irradiation of pancreatic rat islets up to a dose of 2.5 Gy did neither alter glucose-nor IBMX-induced insulin secretion studied in vitro. The insulin as well as glucagon content of irradiated islets were similar as in the control tissue. This was also true in islets irradiated with 25 Gy which were characterized by a decreased insulin secretion in the presence of glucose and IBMX, respectively. Since we did not find indications of an enhanced hormone output in the radiation medium, we want to suggest that higher irradiation doses affect insulin release of pancreatic islets in vitro. This observation has to be taken into account for application of radioimmunosuppression for transplantation.
Publication Date:
Jan 01, 1983
Product Type:
Journal Article
Reference Number:
EDB-84-046033
Resource Relation:
Journal Name: Exp. Clin. Endocrinol.; (German Democratic Republic); Journal Volume: 81:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; PANCREAS; BIOLOGICAL RADIATION EFFECTS; GLUCOSE; HORMONES; IMMUNOSUPPRESSION; IN VITRO; INSULIN; RATS; TISSUE CULTURES; TRANSPLANTS; ALDEHYDES; ANIMALS; BIOLOGICAL EFFECTS; BODY; CARBOHYDRATES; DIGESTIVE SYSTEM; ENDOCRINE GLANDS; GLANDS; HEXOSES; MAMMALS; MONOSACCHARIDES; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; RADIATION EFFECTS; RODENTS; SACCHARIDES; VERTEBRATES; 560121* - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
5272297
Research Organizations:
Central Institute of Diabetes, Research and Treatment, Karlsburg, GDR
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EXCED
Submitting Site:
HEDB
Size:
Pages: 94-97
Announcement Date:

Citation Formats

Heinzmann, D, Nadrowitz, R, Besch, W, Schmidt, W, and Hahn, H J. Decrease of glucose-induced insulin secretion of pancreatic rat islets after irradiation in vitro. Germany: N. p., 1983. Web. doi:10.1055/s-0029-1210213.
Heinzmann, D, Nadrowitz, R, Besch, W, Schmidt, W, & Hahn, H J. Decrease of glucose-induced insulin secretion of pancreatic rat islets after irradiation in vitro. Germany. doi:10.1055/s-0029-1210213.
Heinzmann, D, Nadrowitz, R, Besch, W, Schmidt, W, and Hahn, H J. 1983. "Decrease of glucose-induced insulin secretion of pancreatic rat islets after irradiation in vitro." Germany. doi:10.1055/s-0029-1210213. https://www.osti.gov/servlets/purl/10.1055/s-0029-1210213.
@misc{etde_5272297,
title = {Decrease of glucose-induced insulin secretion of pancreatic rat islets after irradiation in vitro}
author = {Heinzmann, D, Nadrowitz, R, Besch, W, Schmidt, W, and Hahn, H J}
abstractNote = {Irradiation of pancreatic rat islets up to a dose of 2.5 Gy did neither alter glucose-nor IBMX-induced insulin secretion studied in vitro. The insulin as well as glucagon content of irradiated islets were similar as in the control tissue. This was also true in islets irradiated with 25 Gy which were characterized by a decreased insulin secretion in the presence of glucose and IBMX, respectively. Since we did not find indications of an enhanced hormone output in the radiation medium, we want to suggest that higher irradiation doses affect insulin release of pancreatic islets in vitro. This observation has to be taken into account for application of radioimmunosuppression for transplantation.}
doi = {10.1055/s-0029-1210213}
journal = {Exp. Clin. Endocrinol.; (German Democratic Republic)}
volume = {81:1}
journal type = {AC}
place = {Germany}
year = {1983}
month = {Jan}
}