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Identification and analysis of senile plaques using nuclear microscopy

Conference:

Abstract

The senile plaques and neuro-fibrillary tangles which form part of the pathology of Alzheimer's disease have come under increasing scrutiny over the last decade. In particular, much work has been done investigating their elemental composition. The suggestion that 75-100% of tensile plaques with mature cores contain aluminium and silicon, probably in the form of alumino-silicates, has led to increasing speculation about the role of these elements in the disease. SPM preliminary studies suggest that aluminium and silicon are not present in as great a proportion of senile plaques as presented in the literature. The situation is complicated by the fact that airborn and solubilised salts of aluminium and silicon may be encountered as contamination. They have been found, for example, in granular or crystalline form in the Aristar grade organic laboratory reagents used for staining the tissue, and in the pure pioloform used to back the samples. The latest results from scans of stained and unstained Alzheimer tissue are presented. (orig.).
Authors:
Landsberg, J P; Roberts, J M; Grime, G W; Watt, F; [1]  McDonald, B [2] 
  1. Nuclear Physics Lab., Oxford (UK)
  2. Dept. of Neuropathology, Radcliffe Infirmary, Oxford (UK) Nuffield Dept. of Pathology, John Radcliffe Hospital, Oxford (UK) MRC Neuroanatomical Unit, Dept. of Pharmacology, Oxford (UK)
Publication Date:
Mar 01, 1991
Product Type:
Conference
Report Number:
CONF-900223-
Reference Number:
AIX-22-075422; EDB-91-135907
Resource Relation:
Journal Name: Nuclear Instruments and Methods in Physics Research, Section B; (Netherlands); Journal Volume: 54:1-3; Conference: 2. international conference on nuclear microprobe technology and applications, Melbourne (Australia), 5-9 Feb 1990
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; BRAIN; PROTON MICROPROBE ANALYSIS; ALUMINIUM; MAN; MULTI-ELEMENT ANALYSIS; NERVOUS SYSTEM DISEASES; PATHOLOGICAL CHANGES; PIXE ANALYSIS; SILICON; ANIMALS; BODY; CENTRAL NERVOUS SYSTEM; CHEMICAL ANALYSIS; DISEASES; ELEMENTS; MAMMALS; METALS; MICROANALYSIS; NERVOUS SYSTEM; NONDESTRUCTIVE ANALYSIS; ORGANS; PRIMATES; SEMIMETALS; VERTEBRATES; X-RAY EMISSION ANALYSIS; 550602* - Medicine- External Radiation in Diagnostics- (1980-); 550900 - Pathology
OSTI ID:
5271556
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0168-583X; CODEN: NIMBE
Submitting Site:
NLN
Size:
Pages: 180-185
Announcement Date:

Conference:

Citation Formats

Landsberg, J P, Roberts, J M, Grime, G W, Watt, F, and McDonald, B. Identification and analysis of senile plaques using nuclear microscopy. Netherlands: N. p., 1991. Web.
Landsberg, J P, Roberts, J M, Grime, G W, Watt, F, & McDonald, B. Identification and analysis of senile plaques using nuclear microscopy. Netherlands.
Landsberg, J P, Roberts, J M, Grime, G W, Watt, F, and McDonald, B. 1991. "Identification and analysis of senile plaques using nuclear microscopy." Netherlands.
@misc{etde_5271556,
title = {Identification and analysis of senile plaques using nuclear microscopy}
author = {Landsberg, J P, Roberts, J M, Grime, G W, Watt, F, and McDonald, B}
abstractNote = {The senile plaques and neuro-fibrillary tangles which form part of the pathology of Alzheimer's disease have come under increasing scrutiny over the last decade. In particular, much work has been done investigating their elemental composition. The suggestion that 75-100% of tensile plaques with mature cores contain aluminium and silicon, probably in the form of alumino-silicates, has led to increasing speculation about the role of these elements in the disease. SPM preliminary studies suggest that aluminium and silicon are not present in as great a proportion of senile plaques as presented in the literature. The situation is complicated by the fact that airborn and solubilised salts of aluminium and silicon may be encountered as contamination. They have been found, for example, in granular or crystalline form in the Aristar grade organic laboratory reagents used for staining the tissue, and in the pure pioloform used to back the samples. The latest results from scans of stained and unstained Alzheimer tissue are presented. (orig.).}
journal = {Nuclear Instruments and Methods in Physics Research, Section B; (Netherlands)}
volume = {54:1-3}
place = {Netherlands}
year = {1991}
month = {Mar}
}