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Treatment of neuroblastoma. Role of total Body Irradiation

Journal Article:

Abstract

Advanced neuroblastoma, scarcely responsive to conventional therapies, can take advantage of high dose chemio-radiotherapic treatment followed by bone marrow transplant. Nineteen young patients underwent an ablative chemotherapy with high dose Vincristine and Melphalan plus Total Body Irradiation in Genoa, Italy; all of them underwent autologus bone marrow transplantation. Fourteen children were in complete remission (CR), 5 had residual disease. Thirteen are alive after a median of 7 months following transplant; 9 are in CR; 4 have disease; 1 died for toxicity; 5 for relapse. The results seem to suggest that ablative therapy should be given to patients in CR. Toxicity was not remarkable mainly as far as TBI is concerned.
Publication Date:
Jan 01, 1986
Product Type:
Journal Article
Reference Number:
AIX-19-045416; EDB-88-080885
Resource Relation:
Journal Name: Radiol. Med.; (Italy); Journal Volume: 72:12
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; NEOPLASMS; NERVOUS SYSTEM DISEASES; WHOLE-BODY IRRADIATION; BONE MARROW; CHEMOTHERAPY; COBALT 60; RADIOTHERAPY; TRANSPLANTS; ANIMAL TISSUES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COBALT ISOTOPES; DISEASES; EXTERNAL IRRADIATION; HEMATOPOIETIC SYSTEM; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICINE; MINUTES LIVING RADIOISOTOPES; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIOISOTOPES; RADIOLOGY; THERAPY; TISSUES; YEARS LIVING RADIOISOTOPES; 550603* - Medicine- External Radiation in Therapy- (1980-)
OSTI ID:
5270719
Research Organizations:
Istituto Giannina Gaslini, Genoa (Italy). Div. di Ematologia e Oncologia Pediatrica; Genoa Univ. (Italy). Ist. di Radiologia. Cattedre Base
Country of Origin:
Italy
Language:
Italian
Other Identifying Numbers:
Journal ID: CODEN: RAMEA
Submitting Site:
INIS
Size:
Pages: 959-962
Announcement Date:

Journal Article:

Citation Formats

Dini, G, Perin, G P, Franzone, P, Corvo, R, and Scarpati, D. Treatment of neuroblastoma. Role of total Body Irradiation. Italy: N. p., 1986. Web.
Dini, G, Perin, G P, Franzone, P, Corvo, R, & Scarpati, D. Treatment of neuroblastoma. Role of total Body Irradiation. Italy.
Dini, G, Perin, G P, Franzone, P, Corvo, R, and Scarpati, D. 1986. "Treatment of neuroblastoma. Role of total Body Irradiation." Italy.
@misc{etde_5270719,
title = {Treatment of neuroblastoma. Role of total Body Irradiation}
author = {Dini, G, Perin, G P, Franzone, P, Corvo, R, and Scarpati, D}
abstractNote = {Advanced neuroblastoma, scarcely responsive to conventional therapies, can take advantage of high dose chemio-radiotherapic treatment followed by bone marrow transplant. Nineteen young patients underwent an ablative chemotherapy with high dose Vincristine and Melphalan plus Total Body Irradiation in Genoa, Italy; all of them underwent autologus bone marrow transplantation. Fourteen children were in complete remission (CR), 5 had residual disease. Thirteen are alive after a median of 7 months following transplant; 9 are in CR; 4 have disease; 1 died for toxicity; 5 for relapse. The results seem to suggest that ablative therapy should be given to patients in CR. Toxicity was not remarkable mainly as far as TBI is concerned.}
journal = {Radiol. Med.; (Italy)}
volume = {72:12}
journal type = {AC}
place = {Italy}
year = {1986}
month = {Jan}
}