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Determination of serum DNA concentration by enzyme immunoassay (ELISA) in gamma irradiated rats

Journal Article:

Abstract

A sensitive and specific ELISA method was used to determine changes in the serum DNA concentration in rats at hours 6 and 9 and on the days 1, 3, 7, 10, 15 and 30 after acute whole-body gamma irradiation with a dose of 8 Gy. Changes in the DNA serum concentration were determined also on day 10 after irradiation with doses of 4, 6, 8, 10 and 12 Gy. The present results indicate that the pattern of changes in the serum DNA concentration is characterized by an initial decrease, typical also of the leukocyte count, followed by a statistically significant increase in the DNA concentration on day 10 and in later periods of time. These data confirmed, in principle, the authors' previous findings on changes in the DNA concentration in the rat blood plasma after acute X-ray irradiation assessed by the fluorimetric method with ethidium bromide. (author). 4 figs., 14 refs.
Publication Date:
Jan 01, 1987
Product Type:
Journal Article
Reference Number:
AIX-19-044638; EDB-88-080984
Resource Relation:
Journal Name: Biologia (Bratislava); (Czechoslovakia); Journal Volume: 42:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BLOOD SERUM; DNA; ENZYME IMMUNOASSAY; GAMMA RADIATION; LEUKOCYTES; QUANTITY RATIO; RATS; WHOLE-BODY IRRADIATION; X RADIATION; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; IMMUNOASSAY; IONIZING RADIATIONS; IRRADIATION; MAMMALS; MATERIALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; RADIATIONS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
5270238
Research Organizations:
Univerzita P.J. Safarika, Kosice (Czechoslovakia). Katedra Vseobecnej Biologie
Country of Origin:
Serbia and Montenegro
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BLOAA
Submitting Site:
INIS
Size:
Pages: 247-252
Announcement Date:

Journal Article:

Citation Formats

Gabor, J, and Misurova, E. Determination of serum DNA concentration by enzyme immunoassay (ELISA) in gamma irradiated rats. Serbia and Montenegro: N. p., 1987. Web.
Gabor, J, & Misurova, E. Determination of serum DNA concentration by enzyme immunoassay (ELISA) in gamma irradiated rats. Serbia and Montenegro.
Gabor, J, and Misurova, E. 1987. "Determination of serum DNA concentration by enzyme immunoassay (ELISA) in gamma irradiated rats." Serbia and Montenegro.
@misc{etde_5270238,
title = {Determination of serum DNA concentration by enzyme immunoassay (ELISA) in gamma irradiated rats}
author = {Gabor, J, and Misurova, E}
abstractNote = {A sensitive and specific ELISA method was used to determine changes in the serum DNA concentration in rats at hours 6 and 9 and on the days 1, 3, 7, 10, 15 and 30 after acute whole-body gamma irradiation with a dose of 8 Gy. Changes in the DNA serum concentration were determined also on day 10 after irradiation with doses of 4, 6, 8, 10 and 12 Gy. The present results indicate that the pattern of changes in the serum DNA concentration is characterized by an initial decrease, typical also of the leukocyte count, followed by a statistically significant increase in the DNA concentration on day 10 and in later periods of time. These data confirmed, in principle, the authors' previous findings on changes in the DNA concentration in the rat blood plasma after acute X-ray irradiation assessed by the fluorimetric method with ethidium bromide. (author). 4 figs., 14 refs.}
journal = {Biologia (Bratislava); (Czechoslovakia)}
volume = {42:3}
journal type = {AC}
place = {Serbia and Montenegro}
year = {1987}
month = {Jan}
}