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SPECT imaging of dopamine and serotonin transporters with [[sup 123]I][beta]-CIT. Binding kinetics in the human brain

Abstract

Single photon emission computerized tomography (SPECT) studies in non-human primates have previously shown that the cocaine derivative [[sup 123]I]-2-[beta]-carbomethoxy-3-[beta]-(4-iodophenyl)-tropane ([[sup 123]I][beta]-CIT) labels dopamine transporters in the striatum and serotonin transporters in the hypothalamus-midbrain area. Here, we report on the regional kinetic uptake of [[sup 123]I][beta]-CIT in the brain of 4 normal volunteers and 2 patients with Parkinson's disease. In healthy subjects striatal activity increased slowly to reach peak values at about 20 hours post injection. In the hypothalamus-midbrain area peak activities were observed at about 4 hours with a slow decrease thereafter. Low activity was observed in cortical and cerebellar areas. The striatal to cerebellar ratio was about 4 after 5 hours and 9 after 20 hours. In 2 patients with idiopathic Parkinson's disease striatal activity was markedly decreased while the activity in hypothalamus-midbrain areas was only diminished. Uptake into cortical and cerebellar areas appeared to be unchanged in Parkinson's disease. Consequently, in Parkinson's disease the striatal to cerebellar ratio was decreased to values around 2.5 after 20 hours. These preliminary methodological studies suggest that [[sup 123]I][beta]-CIT is a useful SPECT ligand for studying dopamine and possibly also serotonin transporters in the living human brain.
Authors:
Bruecke, T; Asenbaum, S; Frassine, H; Podreka, I; [1]  Kornhuber, J; [2]  Angelberger, P [3] 
  1. Vienna Univ. (Austria). Neurologische Klinik
  2. Wuerzburg Univ. (Germany)
  3. Oesterreichisches Forschungszentrum Seibersdorf GmbH (Austria)
Publication Date:
Jan 01, 1993
Product Type:
Journal Article
Reference Number:
AIX-25-025303; EDB-94-058278
Resource Relation:
Journal Name: Journal of Neural Transmission; (Austria); Journal Volume: 94
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BRAIN; RADIONUCLIDE KINETICS; COCAINE; DOPAMINE; IODINE 123; MAN; NERVOUS SYSTEM DISEASES; SEROTONIN; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; ALKALOIDS; AMINES; ANESTHETICS; ANIMALS; ANTIDEPRESSANTS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZAARENES; AZOLES; BETA DECAY RADIOISOTOPES; BODY; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INDOLES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MAMMALS; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; PRIMATES; PSYCHOTROPIC DRUGS; PYRROLES; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; SYMPATHOMIMETICS; TOMOGRAPHY; TRYPTAMINES; VERTEBRATES; 560161* - Radionuclide Effects, Kinetics, & Toxicology- Man
OSTI ID:
5267974
Country of Origin:
Austria
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0300-9564; CODEN: JNTMAH
Submitting Site:
INIS
Size:
Pages: 137-146
Announcement Date:

Citation Formats

Bruecke, T, Asenbaum, S, Frassine, H, Podreka, I, Kornhuber, J, and Angelberger, P. SPECT imaging of dopamine and serotonin transporters with [[sup 123]I][beta]-CIT. Binding kinetics in the human brain. Austria: N. p., 1993. Web. doi:10.1007/BF01245007.
Bruecke, T, Asenbaum, S, Frassine, H, Podreka, I, Kornhuber, J, & Angelberger, P. SPECT imaging of dopamine and serotonin transporters with [[sup 123]I][beta]-CIT. Binding kinetics in the human brain. Austria. doi:10.1007/BF01245007.
Bruecke, T, Asenbaum, S, Frassine, H, Podreka, I, Kornhuber, J, and Angelberger, P. 1993. "SPECT imaging of dopamine and serotonin transporters with [[sup 123]I][beta]-CIT. Binding kinetics in the human brain." Austria. doi:10.1007/BF01245007. https://www.osti.gov/servlets/purl/10.1007/BF01245007.
@misc{etde_5267974,
title = {SPECT imaging of dopamine and serotonin transporters with [[sup 123]I][beta]-CIT. Binding kinetics in the human brain}
author = {Bruecke, T, Asenbaum, S, Frassine, H, Podreka, I, Kornhuber, J, and Angelberger, P}
abstractNote = {Single photon emission computerized tomography (SPECT) studies in non-human primates have previously shown that the cocaine derivative [[sup 123]I]-2-[beta]-carbomethoxy-3-[beta]-(4-iodophenyl)-tropane ([[sup 123]I][beta]-CIT) labels dopamine transporters in the striatum and serotonin transporters in the hypothalamus-midbrain area. Here, we report on the regional kinetic uptake of [[sup 123]I][beta]-CIT in the brain of 4 normal volunteers and 2 patients with Parkinson's disease. In healthy subjects striatal activity increased slowly to reach peak values at about 20 hours post injection. In the hypothalamus-midbrain area peak activities were observed at about 4 hours with a slow decrease thereafter. Low activity was observed in cortical and cerebellar areas. The striatal to cerebellar ratio was about 4 after 5 hours and 9 after 20 hours. In 2 patients with idiopathic Parkinson's disease striatal activity was markedly decreased while the activity in hypothalamus-midbrain areas was only diminished. Uptake into cortical and cerebellar areas appeared to be unchanged in Parkinson's disease. Consequently, in Parkinson's disease the striatal to cerebellar ratio was decreased to values around 2.5 after 20 hours. These preliminary methodological studies suggest that [[sup 123]I][beta]-CIT is a useful SPECT ligand for studying dopamine and possibly also serotonin transporters in the living human brain.}
doi = {10.1007/BF01245007}
journal = {Journal of Neural Transmission; (Austria)}
volume = {94}
journal type = {AC}
place = {Austria}
year = {1993}
month = {Jan}
}