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Post-irradiation vasculopathy of intracranial major arteries in children; Report of two cases

Abstract

We report two rare cases of post-irradiation vasculopathy of intracranial major arteries in children. A 13-year-old girl suffered from transient right hemiparesis 1 year after irradiation for suprasellar germinoma. Left carotid angiograms revealed marked stenoses of the intracranial internal carotid, middle cerebral, and anterior cerebral arteries, which were previously normal, and moyamoya vessels. A 2.5-year-old girl underwent internal irradiation with {sup 198}Au colloid for cystic craniopharyngioma. At the age of 10 years, she suddenly became unconscious after vomiting. Computed tomographic scans showed a right frontal intracerebral hematoma. Right carotid angiograms disclosed complete obstruction of the intracranial internal carotid, middle cerebral, and anterior cerebral arteries and moyamoya vessels, previously not present. The danger of radiation therapy causing occlusive vasculopathy in small and major cerebral arteries in children is emphasized. To prevent permanent ischemic neurological deficits, vasculopathy should be treated either medically or surgically as early as possible. (author).
Authors:
Nishizawa, Shigeru; Ryu, Hiroshi; Yokoyama, Tetsuo; Ninchoji, Toshiaki; Shimoyama, Ichiro; Yamamoto, Seiji; Uemura, Kenichi [1] 
  1. Hamamatsu Univ. School of Medicine, Shizuoka (Japan)
Publication Date:
Jun 01, 1991
Product Type:
Journal Article
Reference Number:
JPN-91-009231; EDB-91-148280
Resource Relation:
Journal Name: Neurologia Medico-Chirurgica; (Japan); Journal Volume: 31:6
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ARTERIES; RADIATION INJURIES; ATROPHY; CEREBRUM; CHILDREN; DELAYED RADIATION EFFECTS; GOLD 198; HEMORRHAGE; NEOPLASMS; PATIENTS; RADIOTHERAPY; VASOCONSTRICTION; VISION; VOMITING; AGE GROUPS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BLOOD VESSELS; BODY; BRAIN; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DAYS LIVING RADIOISOTOPES; DISEASES; GOLD ISOTOPES; HEAVY NUCLEI; INJURIES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIOISOTOPES; RADIOLOGY; SYMPTOMS; THERAPY; 560151* - Radiation Effects on Animals- Man
OSTI ID:
5262946
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0387-2572; CODEN: NMCHB
Submitting Site:
JPN
Size:
Pages: 336-341
Announcement Date:
Nov 15, 1991

Citation Formats

Nishizawa, Shigeru, Ryu, Hiroshi, Yokoyama, Tetsuo, Ninchoji, Toshiaki, Shimoyama, Ichiro, Yamamoto, Seiji, and Uemura, Kenichi. Post-irradiation vasculopathy of intracranial major arteries in children; Report of two cases. Japan: N. p., 1991. Web.
Nishizawa, Shigeru, Ryu, Hiroshi, Yokoyama, Tetsuo, Ninchoji, Toshiaki, Shimoyama, Ichiro, Yamamoto, Seiji, & Uemura, Kenichi. Post-irradiation vasculopathy of intracranial major arteries in children; Report of two cases. Japan.
Nishizawa, Shigeru, Ryu, Hiroshi, Yokoyama, Tetsuo, Ninchoji, Toshiaki, Shimoyama, Ichiro, Yamamoto, Seiji, and Uemura, Kenichi. 1991. "Post-irradiation vasculopathy of intracranial major arteries in children; Report of two cases." Japan.
@misc{etde_5262946,
title = {Post-irradiation vasculopathy of intracranial major arteries in children; Report of two cases}
author = {Nishizawa, Shigeru, Ryu, Hiroshi, Yokoyama, Tetsuo, Ninchoji, Toshiaki, Shimoyama, Ichiro, Yamamoto, Seiji, and Uemura, Kenichi}
abstractNote = {We report two rare cases of post-irradiation vasculopathy of intracranial major arteries in children. A 13-year-old girl suffered from transient right hemiparesis 1 year after irradiation for suprasellar germinoma. Left carotid angiograms revealed marked stenoses of the intracranial internal carotid, middle cerebral, and anterior cerebral arteries, which were previously normal, and moyamoya vessels. A 2.5-year-old girl underwent internal irradiation with {sup 198}Au colloid for cystic craniopharyngioma. At the age of 10 years, she suddenly became unconscious after vomiting. Computed tomographic scans showed a right frontal intracerebral hematoma. Right carotid angiograms disclosed complete obstruction of the intracranial internal carotid, middle cerebral, and anterior cerebral arteries and moyamoya vessels, previously not present. The danger of radiation therapy causing occlusive vasculopathy in small and major cerebral arteries in children is emphasized. To prevent permanent ischemic neurological deficits, vasculopathy should be treated either medically or surgically as early as possible. (author).}
journal = []
volume = {31:6}
journal type = {AC}
place = {Japan}
year = {1991}
month = {Jun}
}