Abstract
Chromosome studies were performed on peripheral blood lymphocytes of 28 patients with connective tissue disease (6 with progressive systemic sclerosis, 6 with systemic lupus erythematosus, 6 with anti-nuclear antibody positive rheumatoid arthritis, 6 with anti-nuclear antibody negative rheumatoid arthritis, and 4 with mixed connective tissue disease) and on 17 controls to determine the frequency of spontaneous as well as X-ray (75 rads) induced aberrations. The mean spontaneous chromosomal aberration frequency for the 28 patients (9.1%) was significantly (P=0.038) greater than that of controls (6.4%). When patients were categorized into specific clinically designated connective tissue disease subdivisions for comparison with the controls, only X-irradiated cells from the progressive systemic sclerosis group displayed significantly elevated levels of total chromosomal aberrations over those of the control group. The X-irradiated lymphocytes from these patients had an average of 23.6% aberrations per patient, while those of the control group showed an average of 14.9% per patient (P<0.05).
Burkhardt, W C;
Jackson, J F;
Songcharoen, S;
Meydrech, E F
[1]
- Mississippi Univ., Jackson (USA). Medical Center
Citation Formats
Burkhardt, W C, Jackson, J F, Songcharoen, S, and Meydrech, E F.
Spontaneous and X-ray induced chromosomal aberrations in selected connective tissue diseases.
Denmark: N. p.,
1980.
Web.
Burkhardt, W C, Jackson, J F, Songcharoen, S, & Meydrech, E F.
Spontaneous and X-ray induced chromosomal aberrations in selected connective tissue diseases.
Denmark.
Burkhardt, W C, Jackson, J F, Songcharoen, S, and Meydrech, E F.
1980.
"Spontaneous and X-ray induced chromosomal aberrations in selected connective tissue diseases."
Denmark.
@misc{etde_5262626,
title = {Spontaneous and X-ray induced chromosomal aberrations in selected connective tissue diseases}
author = {Burkhardt, W C, Jackson, J F, Songcharoen, S, and Meydrech, E F}
abstractNote = {Chromosome studies were performed on peripheral blood lymphocytes of 28 patients with connective tissue disease (6 with progressive systemic sclerosis, 6 with systemic lupus erythematosus, 6 with anti-nuclear antibody positive rheumatoid arthritis, 6 with anti-nuclear antibody negative rheumatoid arthritis, and 4 with mixed connective tissue disease) and on 17 controls to determine the frequency of spontaneous as well as X-ray (75 rads) induced aberrations. The mean spontaneous chromosomal aberration frequency for the 28 patients (9.1%) was significantly (P=0.038) greater than that of controls (6.4%). When patients were categorized into specific clinically designated connective tissue disease subdivisions for comparison with the controls, only X-irradiated cells from the progressive systemic sclerosis group displayed significantly elevated levels of total chromosomal aberrations over those of the control group. The X-irradiated lymphocytes from these patients had an average of 23.6% aberrations per patient, while those of the control group showed an average of 14.9% per patient (P<0.05).}
journal = []
volume = {17:2}
journal type = {AC}
place = {Denmark}
year = {1980}
month = {Jan}
}
title = {Spontaneous and X-ray induced chromosomal aberrations in selected connective tissue diseases}
author = {Burkhardt, W C, Jackson, J F, Songcharoen, S, and Meydrech, E F}
abstractNote = {Chromosome studies were performed on peripheral blood lymphocytes of 28 patients with connective tissue disease (6 with progressive systemic sclerosis, 6 with systemic lupus erythematosus, 6 with anti-nuclear antibody positive rheumatoid arthritis, 6 with anti-nuclear antibody negative rheumatoid arthritis, and 4 with mixed connective tissue disease) and on 17 controls to determine the frequency of spontaneous as well as X-ray (75 rads) induced aberrations. The mean spontaneous chromosomal aberration frequency for the 28 patients (9.1%) was significantly (P=0.038) greater than that of controls (6.4%). When patients were categorized into specific clinically designated connective tissue disease subdivisions for comparison with the controls, only X-irradiated cells from the progressive systemic sclerosis group displayed significantly elevated levels of total chromosomal aberrations over those of the control group. The X-irradiated lymphocytes from these patients had an average of 23.6% aberrations per patient, while those of the control group showed an average of 14.9% per patient (P<0.05).}
journal = []
volume = {17:2}
journal type = {AC}
place = {Denmark}
year = {1980}
month = {Jan}
}