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Inhibitory effect of Cystenosine on leukopenia by radiation

Journal Article:

Abstract

Cystenosine, composed of Cysteine and Inosine, was given to the patients with malignant tumors during radiotherapy. As radiotherapy, lineac x-ray /sup 60/Co-..gamma.. ray, and 4 MV-betatron were used. Except betatron, a daily dose of 200 to 250 rads was given four times a week, and a total dose reached 5000 to 6000 rads. Administration of Cystenosine was started simultaneously with the onset of the radiotherapy, and 6 tablets a day were given. Of 40 subjects, the drug was very effective in 45 per cents, effective in 37.5 per cents, and ineffective in 17.5 per cents. The effective rate was 82.5 per cents, if the cases with effective and very effective were considered as effective. Of the patients, in whom irradiation field was larger than 15 x 15 cm, the drug was effective in 67 per cents and ineffective in 33 per cents. On the other hand, it was effective in 95 per cents of the patients, in whom irradiation field was middle or small and the size was under above size. Carcinostatic substances were concomitantly given to many of the patients, in whom malignant lymphoma and breast cancer were metastasized in a large extent. In 7 of 9 patients (77.8  More>>
Authors:
Sakurai, T; Nishio, M; Sako, K; Koizumi, Y; Komura, R [1] 
  1. National Hospital of Sapporo (Japan)
Publication Date:
Jul 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-09-360293; EDB-78-046817
Resource Relation:
Journal Name: Shinyaku To Rinsho; (Japan); Journal Volume: 26:7
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CYSTINE; BIOLOGICAL EFFECTS; GAMMA RADIATION; BIOLOGICAL RADIATION EFFECTS; RADIOTHERAPY; SIDE EFFECTS; X RADIATION; CARCINOMAS; INOSINE; LEUKOCYTES; LEUKOPENIA; LYMPHOMAS; RADIOPROTECTIVE SUBSTANCES; AMINO ACIDS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOXYLIC ACIDS; DISEASES; DISULFIDES; DRUGS; ELECTROMAGNETIC RADIATION; HEMIC DISEASES; HETEROCYCLIC COMPOUNDS; IONIZING RADIATIONS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; NUCLEOSIDES; NUCLEOTIDES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PATHOLOGICAL CHANGES; PURINES; RADIATION EFFECTS; RADIATIONS; RADIOLOGY; RESPONSE MODIFYING FACTORS; RIBOSIDES; SYMPTOMS; THERAPY; 560151* - Radiation Effects on Animals- Man
OSTI ID:
5247531
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: SHRIA
Submitting Site:
INIS
Size:
Pages: 1275-1280
Announcement Date:

Journal Article:

Citation Formats

Sakurai, T, Nishio, M, Sako, K, Koizumi, Y, and Komura, R. Inhibitory effect of Cystenosine on leukopenia by radiation. Japan: N. p., 1977. Web.
Sakurai, T, Nishio, M, Sako, K, Koizumi, Y, & Komura, R. Inhibitory effect of Cystenosine on leukopenia by radiation. Japan.
Sakurai, T, Nishio, M, Sako, K, Koizumi, Y, and Komura, R. 1977. "Inhibitory effect of Cystenosine on leukopenia by radiation." Japan.
@misc{etde_5247531,
title = {Inhibitory effect of Cystenosine on leukopenia by radiation}
author = {Sakurai, T, Nishio, M, Sako, K, Koizumi, Y, and Komura, R}
abstractNote = {Cystenosine, composed of Cysteine and Inosine, was given to the patients with malignant tumors during radiotherapy. As radiotherapy, lineac x-ray /sup 60/Co-..gamma.. ray, and 4 MV-betatron were used. Except betatron, a daily dose of 200 to 250 rads was given four times a week, and a total dose reached 5000 to 6000 rads. Administration of Cystenosine was started simultaneously with the onset of the radiotherapy, and 6 tablets a day were given. Of 40 subjects, the drug was very effective in 45 per cents, effective in 37.5 per cents, and ineffective in 17.5 per cents. The effective rate was 82.5 per cents, if the cases with effective and very effective were considered as effective. Of the patients, in whom irradiation field was larger than 15 x 15 cm, the drug was effective in 67 per cents and ineffective in 33 per cents. On the other hand, it was effective in 95 per cents of the patients, in whom irradiation field was middle or small and the size was under above size. Carcinostatic substances were concomitantly given to many of the patients, in whom malignant lymphoma and breast cancer were metastasized in a large extent. In 7 of 9 patients (77.8 per cents), hematopoietic disturbances were inhibited, and prearranged courses of therapy were effectively completed. Although the variation of the number of the blood platelets was not always parallel to that of leukocytes, interruption of the treatment because of the decrease of the blood platelets was found in none of the patients. Neither subjective not objective side effects were seen after the administration of Cystenosine.}
journal = {Shinyaku To Rinsho; (Japan)}
volume = {26:7}
journal type = {AC}
place = {Japan}
year = {1977}
month = {Jul}
}