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Clinical and histological study of radiation-resistant cancer of the larynx

Abstract

In its early stage, cancer of the larynx is treated mainly by irradiation. A clinical and histological study of the radiation-resistant cancer of the larynx is reported. From 1958 to 1976, 1190 patients with squamous cell carcinoma of the larynx were treated at the Department of Otolaryngology, Osaka University Hospital. Among them, 597 patients (50.2%) were treated by radiation therapy. In 180 patients who had developed local recurrence after initial irradiation, partial or total laryngectomies were performed and 5-year crude survival rates were 71.3%. Gross examination of the specimens and histological studies were performed on these cases, as well as microangiography. The majority of recurrent glottic cancers were located at the anterior commissure and had some subglottic extention. In the supraglottic cancers, marked invasion to the pre-epiglottic space, perichondritis, and edema of the arytenoids were observed. These findings suggested that the unsuccessful radiation therapy was due to the diagnostic failure of the tumor extention. Fixation of the affected vocal cords and ulcer formation were also observed. Histologically, cancer cells invaded deeply the surrounding tissues as scattered cancer nests with marked hypoxic stromal reaction. This study suggests that radiation therapy should be the initial but non-repetitive treatment of choice for earlystage  More>>
Authors:
Maeda, K [1] 
  1. Osaka Univ. (Japan). Faculty of Medicine
Publication Date:
Feb 01, 1979
Product Type:
Journal Article
Reference Number:
AIX-11-502683; EDB-80-098578
Resource Relation:
Journal Name: Nippon Jibi Inkoka Gakkai Kaiho; (Japan); Journal Volume: 82:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD VESSELS; BIOLOGICAL RADIATION EFFECTS; EDEMA; RADIOINDUCTION; LARYNX; RADIOTHERAPY; SIDE EFFECTS; ULCERS; BIOMEDICAL RADIOGRAPHY; BLOOD CIRCULATION; CARCINOMAS; GAMMA RADIATION; IRRADIATION; PATIENTS; RADIOSENSITIVITY; ULTRASTRUCTURAL CHANGES; BIOLOGICAL EFFECTS; BODY; CARDIOVASCULAR SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; MEDICINE; MORPHOLOGICAL CHANGES; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIATIONS; RADIOLOGY; RESPIRATORY SYSTEM; SYMPTOMS; THERAPY; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)
OSTI ID:
5244504
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: NJIGA
Submitting Site:
INIS
Size:
Pages: 141-156
Announcement Date:
Mar 01, 1980

Citation Formats

Maeda, K. Clinical and histological study of radiation-resistant cancer of the larynx. Japan: N. p., 1979. Web.
Maeda, K. Clinical and histological study of radiation-resistant cancer of the larynx. Japan.
Maeda, K. 1979. "Clinical and histological study of radiation-resistant cancer of the larynx." Japan.
@misc{etde_5244504,
title = {Clinical and histological study of radiation-resistant cancer of the larynx}
author = {Maeda, K}
abstractNote = {In its early stage, cancer of the larynx is treated mainly by irradiation. A clinical and histological study of the radiation-resistant cancer of the larynx is reported. From 1958 to 1976, 1190 patients with squamous cell carcinoma of the larynx were treated at the Department of Otolaryngology, Osaka University Hospital. Among them, 597 patients (50.2%) were treated by radiation therapy. In 180 patients who had developed local recurrence after initial irradiation, partial or total laryngectomies were performed and 5-year crude survival rates were 71.3%. Gross examination of the specimens and histological studies were performed on these cases, as well as microangiography. The majority of recurrent glottic cancers were located at the anterior commissure and had some subglottic extention. In the supraglottic cancers, marked invasion to the pre-epiglottic space, perichondritis, and edema of the arytenoids were observed. These findings suggested that the unsuccessful radiation therapy was due to the diagnostic failure of the tumor extention. Fixation of the affected vocal cords and ulcer formation were also observed. Histologically, cancer cells invaded deeply the surrounding tissues as scattered cancer nests with marked hypoxic stromal reaction. This study suggests that radiation therapy should be the initial but non-repetitive treatment of choice for earlystage laryngeal cancers.}
journal = []
volume = {82:2}
journal type = {AC}
place = {Japan}
year = {1979}
month = {Feb}
}