Abstract
A review of the Hiroshima-Nagasaki leukemia experience thirteen years after the atomic bomb explosion in those two cities, and comparisons with other collected series of leukemia cases following radiation has again demonstrated beyond reasonable doubt the leukemogenic effect of ionizing radiation on humans. In spite of the heterogeneity of the various study groups there are surprisingly consistent findings. An increased risk of leukemia following doses probably as low as 50 to 100 rads (air-entry dose) whole body radiation has been demonstrated. Above this dose the increase in incidence of leukemia may be related linearly to dose of radiation. When extrapolated to zero dose this line intersects the expected spontaneous incidence. In the lower range it is impossible to be certain regarding the presence or absence of a threshold. As in other series the acute lymphocytic variety of leukemia in the very young is most increased. Chronic granulocytic leukemia was seen most commonly among the Japanese in the older age groups. The predilection of the various types of leukemia for specific age groups does not appear to be markedly altered although possibly the incidence of chronic granulocytic leukemia has been shifted to younger ages. Males and children in the age group
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Citation Formats
Brill, A B, Tomonaga, Masanobu, and Heyssel, R M.
Leukemia in humans following exposure to ionizing radiation. A summary of the findings in Hiroshima and Nagasaki and comparison with other human experience.
Japan: N. p.,
1960.
Web.
Brill, A B, Tomonaga, Masanobu, & Heyssel, R M.
Leukemia in humans following exposure to ionizing radiation. A summary of the findings in Hiroshima and Nagasaki and comparison with other human experience.
Japan.
Brill, A B, Tomonaga, Masanobu, and Heyssel, R M.
1960.
"Leukemia in humans following exposure to ionizing radiation. A summary of the findings in Hiroshima and Nagasaki and comparison with other human experience."
Japan.
@misc{etde_5240508,
title = {Leukemia in humans following exposure to ionizing radiation. A summary of the findings in Hiroshima and Nagasaki and comparison with other human experience}
author = {Brill, A B, Tomonaga, Masanobu, and Heyssel, R M}
abstractNote = {A review of the Hiroshima-Nagasaki leukemia experience thirteen years after the atomic bomb explosion in those two cities, and comparisons with other collected series of leukemia cases following radiation has again demonstrated beyond reasonable doubt the leukemogenic effect of ionizing radiation on humans. In spite of the heterogeneity of the various study groups there are surprisingly consistent findings. An increased risk of leukemia following doses probably as low as 50 to 100 rads (air-entry dose) whole body radiation has been demonstrated. Above this dose the increase in incidence of leukemia may be related linearly to dose of radiation. When extrapolated to zero dose this line intersects the expected spontaneous incidence. In the lower range it is impossible to be certain regarding the presence or absence of a threshold. As in other series the acute lymphocytic variety of leukemia in the very young is most increased. Chronic granulocytic leukemia was seen most commonly among the Japanese in the older age groups. The predilection of the various types of leukemia for specific age groups does not appear to be markedly altered although possibly the incidence of chronic granulocytic leukemia has been shifted to younger ages. Males and children in the age group below ten appear to be most sensitive to induction of leukemia by irradiation. The increased occurrenc of leukemia in an irradiated population appears to start about eighteen months after the event. In Japan the increased risk has persisted for thirteen years with the time of maximum risk approximately four to eight years following radiation. 128 references, 2 figures, 14 tables.}
place = {Japan}
year = {1960}
month = {Oct}
}
title = {Leukemia in humans following exposure to ionizing radiation. A summary of the findings in Hiroshima and Nagasaki and comparison with other human experience}
author = {Brill, A B, Tomonaga, Masanobu, and Heyssel, R M}
abstractNote = {A review of the Hiroshima-Nagasaki leukemia experience thirteen years after the atomic bomb explosion in those two cities, and comparisons with other collected series of leukemia cases following radiation has again demonstrated beyond reasonable doubt the leukemogenic effect of ionizing radiation on humans. In spite of the heterogeneity of the various study groups there are surprisingly consistent findings. An increased risk of leukemia following doses probably as low as 50 to 100 rads (air-entry dose) whole body radiation has been demonstrated. Above this dose the increase in incidence of leukemia may be related linearly to dose of radiation. When extrapolated to zero dose this line intersects the expected spontaneous incidence. In the lower range it is impossible to be certain regarding the presence or absence of a threshold. As in other series the acute lymphocytic variety of leukemia in the very young is most increased. Chronic granulocytic leukemia was seen most commonly among the Japanese in the older age groups. The predilection of the various types of leukemia for specific age groups does not appear to be markedly altered although possibly the incidence of chronic granulocytic leukemia has been shifted to younger ages. Males and children in the age group below ten appear to be most sensitive to induction of leukemia by irradiation. The increased occurrenc of leukemia in an irradiated population appears to start about eighteen months after the event. In Japan the increased risk has persisted for thirteen years with the time of maximum risk approximately four to eight years following radiation. 128 references, 2 figures, 14 tables.}
place = {Japan}
year = {1960}
month = {Oct}
}