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Tumor-specific binding of radiolabeled G-22 monoclonal antibody in glioma patients

Journal Article:

Abstract

Iodine-131-labeled G-22 monoclonal antibody F(ab'){sub 2} fragment reacting specifically with a glioma-associated surface glycoprotein was administered to 12 glioma patients to investigate its use in radioimaging of intracranial gliomas. No immediate or delayed side effects were attributable to antibody injection. Nine patients received the radiolabeled complex intravenously. The images of low-grade gliomas were generally poor and disappeared within 4 days. High-contrast images were obtained beyond the 7th day in high-grade gliomas except one case in the pineal region. Three patients received intraventricular or intratumoral administration. Clear images of all tumors were demonstrated from the 2nd until later than the 7th day. One patient with cerebrospinal fluid (CSF) dissemination of brainstem glioma demonstrated negative CSF cytology after intraventricular administration. (author).
Authors:
Publication Date:
Mar 01, 1992
Product Type:
Journal Article
Reference Number:
JPN-92-005282; EDB-92-104734
Resource Relation:
Journal Name: Neurologia Medico-Chirurgica; (Japan); Journal Volume: 32:3
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; RADIOIMMUNODETECTION; IODINE 131; MONOCLONAL ANTIBODIES; AFFINITY; CEREBROSPINAL FLUID; GLIOMAS; GLYCOPROTEINS; LABELLING; UPTAKE; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CENTRAL NERVOUS SYSTEM; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MATERIALS; NEOPLASMS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5229149
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0387-2572; CODEN: NMCHB
Submitting Site:
JPN
Size:
Pages: 125-129
Announcement Date:

Journal Article:

Citation Formats

Yoshida, Jun, Wakabayashi, Toshihiko, Mizuno, Masaaki, Sugita, Kenichiro, Oshima, Motoo, Tadokoro, Masanori, Sakuma, Sadayuki, and Seo, Hisao. Tumor-specific binding of radiolabeled G-22 monoclonal antibody in glioma patients. Japan: N. p., 1992. Web.
Yoshida, Jun, Wakabayashi, Toshihiko, Mizuno, Masaaki, Sugita, Kenichiro, Oshima, Motoo, Tadokoro, Masanori, Sakuma, Sadayuki, & Seo, Hisao. Tumor-specific binding of radiolabeled G-22 monoclonal antibody in glioma patients. Japan.
Yoshida, Jun, Wakabayashi, Toshihiko, Mizuno, Masaaki, Sugita, Kenichiro, Oshima, Motoo, Tadokoro, Masanori, Sakuma, Sadayuki, and Seo, Hisao. 1992. "Tumor-specific binding of radiolabeled G-22 monoclonal antibody in glioma patients." Japan.
@misc{etde_5229149,
title = {Tumor-specific binding of radiolabeled G-22 monoclonal antibody in glioma patients}
author = {Yoshida, Jun, Wakabayashi, Toshihiko, Mizuno, Masaaki, Sugita, Kenichiro, Oshima, Motoo, Tadokoro, Masanori, Sakuma, Sadayuki, and Seo, Hisao}
abstractNote = {Iodine-131-labeled G-22 monoclonal antibody F(ab'){sub 2} fragment reacting specifically with a glioma-associated surface glycoprotein was administered to 12 glioma patients to investigate its use in radioimaging of intracranial gliomas. No immediate or delayed side effects were attributable to antibody injection. Nine patients received the radiolabeled complex intravenously. The images of low-grade gliomas were generally poor and disappeared within 4 days. High-contrast images were obtained beyond the 7th day in high-grade gliomas except one case in the pineal region. Three patients received intraventricular or intratumoral administration. Clear images of all tumors were demonstrated from the 2nd until later than the 7th day. One patient with cerebrospinal fluid (CSF) dissemination of brainstem glioma demonstrated negative CSF cytology after intraventricular administration. (author).}
journal = {Neurologia Medico-Chirurgica; (Japan)}
volume = {32:3}
journal type = {AC}
place = {Japan}
year = {1992}
month = {Mar}
}