Abstract
The synthesis of phenyl-U-carbon-13 labelled D, L-norepinephrine from catechol-U-/sup 13/C in three steps is described. In the first step, the Friedel-Crafts acylation of the labelled part with N-phthaloylglycylchloride yielded the aromatic ketone adduct. Subsequent hydrolysis and catalytic hydrogenation produced the desired product in a 5% overall yield.
Citation Formats
Weisz, A, and Markey, S P.
Synthesis of DL-norepinephrine-(phenyl-U-/sup 13/C).
United Kingdom: N. p.,
1988.
Web.
doi:10.1002/jlcr.2580250113.
Weisz, A, & Markey, S P.
Synthesis of DL-norepinephrine-(phenyl-U-/sup 13/C).
United Kingdom.
https://doi.org/10.1002/jlcr.2580250113
Weisz, A, and Markey, S P.
1988.
"Synthesis of DL-norepinephrine-(phenyl-U-/sup 13/C)."
United Kingdom.
https://doi.org/10.1002/jlcr.2580250113.
@misc{etde_5216949,
title = {Synthesis of DL-norepinephrine-(phenyl-U-/sup 13/C)}
author = {Weisz, A, and Markey, S P}
abstractNote = {The synthesis of phenyl-U-carbon-13 labelled D, L-norepinephrine from catechol-U-/sup 13/C in three steps is described. In the first step, the Friedel-Crafts acylation of the labelled part with N-phthaloylglycylchloride yielded the aromatic ketone adduct. Subsequent hydrolysis and catalytic hydrogenation produced the desired product in a 5% overall yield.}
doi = {10.1002/jlcr.2580250113}
journal = []
volume = {25:1}
journal type = {AC}
place = {United Kingdom}
year = {1988}
month = {Jan}
}
title = {Synthesis of DL-norepinephrine-(phenyl-U-/sup 13/C)}
author = {Weisz, A, and Markey, S P}
abstractNote = {The synthesis of phenyl-U-carbon-13 labelled D, L-norepinephrine from catechol-U-/sup 13/C in three steps is described. In the first step, the Friedel-Crafts acylation of the labelled part with N-phthaloylglycylchloride yielded the aromatic ketone adduct. Subsequent hydrolysis and catalytic hydrogenation produced the desired product in a 5% overall yield.}
doi = {10.1002/jlcr.2580250113}
journal = []
volume = {25:1}
journal type = {AC}
place = {United Kingdom}
year = {1988}
month = {Jan}
}