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Multiple daily fractionation in radiotherapy: biological rationale and preliminary clinical experiences

Journal Article:

Abstract

The biological bases of radiation dose fractionation are reviewed and discussed with special emphasis on reassortment. Experimental data on animal model systems are presented to clarify that reassortment has to be added to sublethal damage repair and reoxygenation in the rationale for an optimized radiotherapy course according to tumor cell kinetics. Clinical results on several human tumors treated with twice or thrice daily fractions are described. These results show that some clinically radioresistant tumors (especially if not characterized by a relatively long clinical doubling line) can be satisfactorily dealt with using multiple daily fractionation. Clinical observations indicate that a relatively high cumulative daily dose (200 + 150 + 150 rad) can be safely administered.
Authors:
Arcangeli, G; [1]  Mauro, F; Morelli, D; Nervi, C
  1. Instituto Medico Scientifico, Rome (Italy). Dept. of Oncology
Publication Date:
Sep 01, 1979
Product Type:
Journal Article
Reference Number:
AIX-11-502663; EDB-80-098425
Resource Relation:
Journal Name: Eur. J. Cancer; (United Kingdom); Journal Volume: 15:9
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; FRACTIONATED IRRADIATION; RADIOSENSITIVITY EFFECTS; RADIOTHERAPY; TUMOR CELLS; RADIOSENSITIVITY; BIOLOGICAL REPAIR; CUMULATIVE RADIATION EFFECTS; NEOPLASMS; OPTIMIZATION; RADIATION DOSES; SAFETY; ANIMAL CELLS; BIOLOGICAL RECOVERY; DISEASES; DOSES; IRRADIATION; MEDICINE; NUCLEAR MEDICINE; RADIOLOGY; RECOVERY; REPAIR; THERAPY; 550603* - Medicine- External Radiation in Therapy- (1980-); 560152 - Radiation Effects on Animals- Animals
OSTI ID:
5211746
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EJCAA
Submitting Site:
INIS
Size:
Pages: 1077-1083
Announcement Date:

Journal Article:

Citation Formats

Arcangeli, G, Mauro, F, Morelli, D, and Nervi, C. Multiple daily fractionation in radiotherapy: biological rationale and preliminary clinical experiences. United Kingdom: N. p., 1979. Web.
Arcangeli, G, Mauro, F, Morelli, D, & Nervi, C. Multiple daily fractionation in radiotherapy: biological rationale and preliminary clinical experiences. United Kingdom.
Arcangeli, G, Mauro, F, Morelli, D, and Nervi, C. 1979. "Multiple daily fractionation in radiotherapy: biological rationale and preliminary clinical experiences." United Kingdom.
@misc{etde_5211746,
title = {Multiple daily fractionation in radiotherapy: biological rationale and preliminary clinical experiences}
author = {Arcangeli, G, Mauro, F, Morelli, D, and Nervi, C}
abstractNote = {The biological bases of radiation dose fractionation are reviewed and discussed with special emphasis on reassortment. Experimental data on animal model systems are presented to clarify that reassortment has to be added to sublethal damage repair and reoxygenation in the rationale for an optimized radiotherapy course according to tumor cell kinetics. Clinical results on several human tumors treated with twice or thrice daily fractions are described. These results show that some clinically radioresistant tumors (especially if not characterized by a relatively long clinical doubling line) can be satisfactorily dealt with using multiple daily fractionation. Clinical observations indicate that a relatively high cumulative daily dose (200 + 150 + 150 rad) can be safely administered.}
journal = {Eur. J. Cancer; (United Kingdom)}
volume = {15:9}
journal type = {AC}
place = {United Kingdom}
year = {1979}
month = {Sep}
}