Abstract
Experimental measurements have shown that both BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) and CCNU (1-(2-choroethyl)-3-cyclohexyl-1-nitrosourea) are toxic in rat 9L brain tumour cells and also sensitize these cells to the action of ionizing radiation. The interaction of BCNU and CCNU with radiation has been interpreted using a recently developed extension of the molecular theory of cell survival. The experimental results are shown to be compatible with the mathematical equations predicted by the model and the analysis indicates that the sensitizing effect is caused by a synergistic interaction between sublethal damage caused by the nitrosourea compound and the radiation at the molecular level. The analysis of the dependence of the interaction on the time between nitrosourea treatment and radiation indicates that the optimal interaction occurs with a 5 hour interval.
Leenhouts, H P;
Chadwick, K H;
[1]
Deen, D F
[2]
- Association Euratom-ITAL, Wageningen (Netherlands)
- California Univ., San Francisco (USA). Dept. of Neurology
Citation Formats
Leenhouts, H P, Chadwick, K H, and Deen, D F.
Analysis of the interaction between two nitrosourea compounds and X-irradiation in rat brain tumour cells.
United Kingdom: N. p.,
1980.
Web.
doi:10.1080/09553008014550211.
Leenhouts, H P, Chadwick, K H, & Deen, D F.
Analysis of the interaction between two nitrosourea compounds and X-irradiation in rat brain tumour cells.
United Kingdom.
https://doi.org/10.1080/09553008014550211
Leenhouts, H P, Chadwick, K H, and Deen, D F.
1980.
"Analysis of the interaction between two nitrosourea compounds and X-irradiation in rat brain tumour cells."
United Kingdom.
https://doi.org/10.1080/09553008014550211.
@misc{etde_5210068,
title = {Analysis of the interaction between two nitrosourea compounds and X-irradiation in rat brain tumour cells}
author = {Leenhouts, H P, Chadwick, K H, and Deen, D F}
abstractNote = {Experimental measurements have shown that both BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) and CCNU (1-(2-choroethyl)-3-cyclohexyl-1-nitrosourea) are toxic in rat 9L brain tumour cells and also sensitize these cells to the action of ionizing radiation. The interaction of BCNU and CCNU with radiation has been interpreted using a recently developed extension of the molecular theory of cell survival. The experimental results are shown to be compatible with the mathematical equations predicted by the model and the analysis indicates that the sensitizing effect is caused by a synergistic interaction between sublethal damage caused by the nitrosourea compound and the radiation at the molecular level. The analysis of the dependence of the interaction on the time between nitrosourea treatment and radiation indicates that the optimal interaction occurs with a 5 hour interval.}
doi = {10.1080/09553008014550211}
journal = []
volume = {37:2}
journal type = {AC}
place = {United Kingdom}
year = {1980}
month = {Feb}
}
title = {Analysis of the interaction between two nitrosourea compounds and X-irradiation in rat brain tumour cells}
author = {Leenhouts, H P, Chadwick, K H, and Deen, D F}
abstractNote = {Experimental measurements have shown that both BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) and CCNU (1-(2-choroethyl)-3-cyclohexyl-1-nitrosourea) are toxic in rat 9L brain tumour cells and also sensitize these cells to the action of ionizing radiation. The interaction of BCNU and CCNU with radiation has been interpreted using a recently developed extension of the molecular theory of cell survival. The experimental results are shown to be compatible with the mathematical equations predicted by the model and the analysis indicates that the sensitizing effect is caused by a synergistic interaction between sublethal damage caused by the nitrosourea compound and the radiation at the molecular level. The analysis of the dependence of the interaction on the time between nitrosourea treatment and radiation indicates that the optimal interaction occurs with a 5 hour interval.}
doi = {10.1080/09553008014550211}
journal = []
volume = {37:2}
journal type = {AC}
place = {United Kingdom}
year = {1980}
month = {Feb}
}