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Molecular pharmacology of cell receptors for cardiac glycosides, opiates, ACTH and ion channel modulators

Thesis/Dissertation:

Abstract

The influence of light and oxygen on molecular interactions between the artificial food dye, erythrosine (ERY), and (/sup 3/H)ouabain ((/sup 3/H)OUA) binding sites on (Na/sup +/ + K/sup +/)-ATPase in rat brain and guinea pig heart was investigated. Putative endogenous digitalis-like factors (DLF's) were studied in four in vitro assays for cardiac glycosides. (/sup 3/H)Etorphine binding was characterized in rat brain homogenates, depleted of opioids, from animals acutely and chronically treated with morphine and naloxone, and either unstressed or cold-restraint-stressed. Binding sites for the ion channel modulators (/sup 3/H)verapamil ((/sup 3/H)VER) and (/sup 3/H) phencyclidine ((/sup 3/H)PCP) were characterized in rat brain.
Authors:
Publication Date:
Jan 01, 1986
Product Type:
Thesis/Dissertation
Reference Number:
EDB-88-093463
Resource Relation:
Other Information: Thesis (Ph. D.)
Subject:
59 BASIC BIOLOGICAL SCIENCES; CARDIAC GLYCOSIDES; RECEPTORS; HORMONES; OPIUM; MOLECULAR BIOLOGY; VASODILATORS; ATP-ASE; BIOCHEMICAL REACTION KINETICS; BRAIN; GUINEA PIGS; HEART; OUABAIN; RATS; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ACID ANHYDRASES; ANALGESICS; ANIMALS; BODY; CARBOHYDRATES; CARDIOTONICS; CARDIOVASCULAR AGENTS; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DRUGS; ENZYMES; GLYCOSIDES; HYDROLASES; ISOTOPE APPLICATIONS; KINETICS; LABELLED COMPOUNDS; MAMMALS; MEMBRANE PROTEINS; NARCOTICS; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANS; PHOSPHOHYDROLASES; PROTEINS; REACTION KINETICS; RODENTS; STROPHANTHINS; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques
OSTI ID:
5209078
Research Organizations:
Manitoba Univ., Winnipeg (Canada)
Country of Origin:
Canada
Language:
English
Availability:
National Library of Canada, Ottawa.
Submitting Site:
JMT
Size:
Pages: v
Announcement Date:

Thesis/Dissertation:

Citation Formats

Hnatowich, M R. Molecular pharmacology of cell receptors for cardiac glycosides, opiates, ACTH and ion channel modulators. Canada: N. p., 1986. Web.
Hnatowich, M R. Molecular pharmacology of cell receptors for cardiac glycosides, opiates, ACTH and ion channel modulators. Canada.
Hnatowich, M R. 1986. "Molecular pharmacology of cell receptors for cardiac glycosides, opiates, ACTH and ion channel modulators." Canada.
@misc{etde_5209078,
title = {Molecular pharmacology of cell receptors for cardiac glycosides, opiates, ACTH and ion channel modulators}
author = {Hnatowich, M R}
abstractNote = {The influence of light and oxygen on molecular interactions between the artificial food dye, erythrosine (ERY), and (/sup 3/H)ouabain ((/sup 3/H)OUA) binding sites on (Na/sup +/ + K/sup +/)-ATPase in rat brain and guinea pig heart was investigated. Putative endogenous digitalis-like factors (DLF's) were studied in four in vitro assays for cardiac glycosides. (/sup 3/H)Etorphine binding was characterized in rat brain homogenates, depleted of opioids, from animals acutely and chronically treated with morphine and naloxone, and either unstressed or cold-restraint-stressed. Binding sites for the ion channel modulators (/sup 3/H)verapamil ((/sup 3/H)VER) and (/sup 3/H) phencyclidine ((/sup 3/H)PCP) were characterized in rat brain.}
place = {Canada}
year = {1986}
month = {Jan}
}