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Pseudotumoral delayed cerebral radionecrosis

Journal Article:

Abstract

A 60 year-old woman with a scalp epithelioma underwent radiotherapy, the dose being 57 Gray. A first epileptic seizure occurred twenty months later. Neurological examination revealed signs of left hemisphere involvement. ..gamma..EG, angiography, CT scans, demonstrated a pseudotumoral avascular process. On account of the localisation, the patient being right-handed, no surgical procedure was performed. In spite of corticotherapy and anticonvulsive treatment, seizures recurred and neurological signs slowly progressed. The patient died, 22 months after the first seizure, of an associated disseminated carcinoma with cachexia. Neuropathological examination showed a massive lesion presenting all the features of delayed radionecrosis in the left hemisphere: situated mainly in the white matter; numerous vascular abnormalities; wide-spread demyelination; disappearance of oligoglial cells. The Authors recall the clinical and anatomical aspects of this condition for which the only successful treatment is surgical removal when location and size of the lesion permit. Finally, the mechanisms which have been proposed to explain this delayed cerebral radionecrosis are discussed.
Authors:
Ciaudo-Lacroix, C; Lapresle, J [1] 
  1. Centre Hospitalier de Bicetre, 94 - Le Kremlin-Bicetre (France)
Publication Date:
Jan 01, 1985
Product Type:
Journal Article
Reference Number:
FR-85-01561; EDB-85-159060
Resource Relation:
Journal Name: Ann. Med. Interne; (France); Journal Volume: 136:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; DELAYED RADIATION EFFECTS; RADIOTHERAPY; SIDE EFFECTS; NECROSIS; RADIOINDUCTION; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIOLOGY; THERAPY; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)
OSTI ID:
5197943
Country of Origin:
France
Language:
French
Other Identifying Numbers:
Journal ID: CODEN: AMDIB
Submitting Site:
HEDB
Size:
Pages: 137-141
Announcement Date:
Sep 01, 1985

Journal Article:

Citation Formats

Ciaudo-Lacroix, C, and Lapresle, J. Pseudotumoral delayed cerebral radionecrosis. France: N. p., 1985. Web.
Ciaudo-Lacroix, C, & Lapresle, J. Pseudotumoral delayed cerebral radionecrosis. France.
Ciaudo-Lacroix, C, and Lapresle, J. 1985. "Pseudotumoral delayed cerebral radionecrosis." France.
@misc{etde_5197943,
title = {Pseudotumoral delayed cerebral radionecrosis}
author = {Ciaudo-Lacroix, C, and Lapresle, J}
abstractNote = {A 60 year-old woman with a scalp epithelioma underwent radiotherapy, the dose being 57 Gray. A first epileptic seizure occurred twenty months later. Neurological examination revealed signs of left hemisphere involvement. ..gamma..EG, angiography, CT scans, demonstrated a pseudotumoral avascular process. On account of the localisation, the patient being right-handed, no surgical procedure was performed. In spite of corticotherapy and anticonvulsive treatment, seizures recurred and neurological signs slowly progressed. The patient died, 22 months after the first seizure, of an associated disseminated carcinoma with cachexia. Neuropathological examination showed a massive lesion presenting all the features of delayed radionecrosis in the left hemisphere: situated mainly in the white matter; numerous vascular abnormalities; wide-spread demyelination; disappearance of oligoglial cells. The Authors recall the clinical and anatomical aspects of this condition for which the only successful treatment is surgical removal when location and size of the lesion permit. Finally, the mechanisms which have been proposed to explain this delayed cerebral radionecrosis are discussed.}
journal = {Ann. Med. Interne; (France)}
volume = {136:2}
journal type = {AC}
place = {France}
year = {1985}
month = {Jan}
}