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Photodynamic activity of polycyclic hydrocarbon

Journal Article:

Abstract

Exposure of Paramecium caudatum to suspensions of 3,4-benzopyrene, followed by long wave ultraviolet irradiation, results in cell death at times related, inter alia, to carcinogen concentration. Prior to death, the cells exhibit progressive immobilization and blebbing. This photodynamic response is a sensitized photo-oxidation, as it is oxygen-dependent and inhibited by anti-oxidants, such as butylated hydroxy anisole and ..cap alpha..-tocopherol. Protection is also afforded by other agents, including Tweens, tryptophan and certain fractions of plasma proteins. No evidence was found for the involvement of peroxides or sulfhydryl groups. The correlations between photodynamic toxicity and carcinogenicity in a large series of polycyclic hydrocarbons is under investigation. Assays of air extracts for photodynamic toxicity are in progress. Significant toxicity has been found in oxygenated besides aromatic fractions.
Authors:
Publication Date:
Jan 01, 1963
Product Type:
Journal Article
Reference Number:
EDB-85-159163
Resource Relation:
Journal Name: Extrait de Acta Union Internationale Contre le Cancer; (France); Journal Volume: 19:3-4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BENZOPYRENE; TOXICITY; PARAMECIUM; SENSITIVITY; ANISOLE; CARCINOGENS; CELL KILLING; PEROXIDES; PHOTOCHEMICAL REACTIONS; POLYCYCLIC AROMATIC HYDROCARBONS; PROTEINS; RESPONSE MODIFYING FACTORS; THIOLS; ULTRAVIOLET RADIATION; ANIMALS; AROMATICS; CHEMICAL REACTIONS; CILIATA; CONDENSED AROMATICS; ELECTROMAGNETIC RADIATION; ETHERS; HYDROCARBONS; INVERTEBRATES; MICROORGANISMS; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; OXYGEN COMPOUNDS; PROTOZOA; RADIATIONS; 560302* - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)
OSTI ID:
5196931
Research Organizations:
Harvard Medical School Boston, MA
Country of Origin:
France
Language:
English
Submitting Site:
HEDB
Size:
Pages: 599-601
Announcement Date:
Aug 01, 1985

Journal Article:

Citation Formats

Epstein, S S. Photodynamic activity of polycyclic hydrocarbon. France: N. p., 1963. Web.
Epstein, S S. Photodynamic activity of polycyclic hydrocarbon. France.
Epstein, S S. 1963. "Photodynamic activity of polycyclic hydrocarbon." France.
@misc{etde_5196931,
title = {Photodynamic activity of polycyclic hydrocarbon}
author = {Epstein, S S}
abstractNote = {Exposure of Paramecium caudatum to suspensions of 3,4-benzopyrene, followed by long wave ultraviolet irradiation, results in cell death at times related, inter alia, to carcinogen concentration. Prior to death, the cells exhibit progressive immobilization and blebbing. This photodynamic response is a sensitized photo-oxidation, as it is oxygen-dependent and inhibited by anti-oxidants, such as butylated hydroxy anisole and ..cap alpha..-tocopherol. Protection is also afforded by other agents, including Tweens, tryptophan and certain fractions of plasma proteins. No evidence was found for the involvement of peroxides or sulfhydryl groups. The correlations between photodynamic toxicity and carcinogenicity in a large series of polycyclic hydrocarbons is under investigation. Assays of air extracts for photodynamic toxicity are in progress. Significant toxicity has been found in oxygenated besides aromatic fractions.}
journal = {Extrait de Acta Union Internationale Contre le Cancer; (France)}
volume = {19:3-4}
journal type = {AC}
place = {France}
year = {1963}
month = {Jan}
}