You need JavaScript to view this

Factors influencing insulin and glucagon secretion in lean and genetically obese mice

Journal Article:

Abstract

The control of /sup 125/I-labelled insulin and glucagon secretion from isolated pancreatic islets of lean and genetically obese mice has been compared. The enlarged islets of obese mouse pancreas and islets of obese mice maintained on a restricted diet manifested a greater response to glucose stimulation of insulin secretion than the lean mice islets. The glucagon content of the islets, the secretion of glucagon in a medium containing 150 mg% glucose and the stimulation of glucagon secretion by arginine did not differ significantly in the two groups. Adrenaline stimulated glucagon secretion in vitro from obese mice but not from lean mice. Antiinsulin serum injections into obese mice increased the plasma glucagon levels about twofold and had no effect on glucagon levels in lean mice, although the level of hyperglycaemia was the same in both groups. It is suggested that the suppression of glucagon release by glucose requires a higher concentration of insulin in the obese mouse pancreas than in lean mice.
Authors:
Beloff-Chain, A; Newman, M E; Mansford, K R.L. [1] 
  1. Imperial Coll. of Science and Technology, London (UK). Dept. of Biochemistry
Publication Date:
Jan 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-09-352153; EDB-78-051603
Resource Relation:
Journal Name: Horm. Metab. Res.; (Germany, Federal Republic of); Journal Volume: 9:1
Subject:
59 BASIC BIOLOGICAL SCIENCES; GLUCAGON; SECRETION; HORMONES; INSULIN; METABOLIC DISEASES; TRACER TECHNIQUES; PANCREAS; ADRENALINE; AMINO ACIDS; GLUCOSE; IODINE 125; LABELLING; MICE; STIMULATION; ADRENAL HORMONES; ALDEHYDES; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CARBOXYLIC ACIDS; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; ENDOCRINE GLANDS; GLANDS; HEXOSES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MONOSACCHARIDES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PEPTIDES; POLYPEPTIDES; PROTEINS; RADIOISOTOPES; RODENTS; SACCHARIDES; STEROID HORMONES; SYMPATHOMIMETICS; VERTEBRATES; 550501* - Metabolism- Tracer Techniques
OSTI ID:
5187098
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: HMMRA
Submitting Site:
INIS
Size:
Pages: 33-37
Announcement Date:

Journal Article:

Citation Formats

Beloff-Chain, A, Newman, M E, and Mansford, K R.L. Factors influencing insulin and glucagon secretion in lean and genetically obese mice. Germany: N. p., 1977. Web.
Beloff-Chain, A, Newman, M E, & Mansford, K R.L. Factors influencing insulin and glucagon secretion in lean and genetically obese mice. Germany.
Beloff-Chain, A, Newman, M E, and Mansford, K R.L. 1977. "Factors influencing insulin and glucagon secretion in lean and genetically obese mice." Germany.
@misc{etde_5187098,
title = {Factors influencing insulin and glucagon secretion in lean and genetically obese mice}
author = {Beloff-Chain, A, Newman, M E, and Mansford, K R.L.}
abstractNote = {The control of /sup 125/I-labelled insulin and glucagon secretion from isolated pancreatic islets of lean and genetically obese mice has been compared. The enlarged islets of obese mouse pancreas and islets of obese mice maintained on a restricted diet manifested a greater response to glucose stimulation of insulin secretion than the lean mice islets. The glucagon content of the islets, the secretion of glucagon in a medium containing 150 mg% glucose and the stimulation of glucagon secretion by arginine did not differ significantly in the two groups. Adrenaline stimulated glucagon secretion in vitro from obese mice but not from lean mice. Antiinsulin serum injections into obese mice increased the plasma glucagon levels about twofold and had no effect on glucagon levels in lean mice, although the level of hyperglycaemia was the same in both groups. It is suggested that the suppression of glucagon release by glucose requires a higher concentration of insulin in the obese mouse pancreas than in lean mice.}
journal = {Horm. Metab. Res.; (Germany, Federal Republic of)}
volume = {9:1}
journal type = {AC}
place = {Germany}
year = {1977}
month = {Jan}
}