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Radiation induced alterations in the endotoxin of S. typhimurium

Abstract

The lipopolysaccharide (LPS) of S. typhimurium has been shown to be significantly detoxified after in vivo irradiation at 500 krad. Radiation is thus a useful method for converting endotoxin into toxoid. The structural alterations in the detoxified LPS were shown to be mainly in the lipid A molecule, resulting in the loss of ..beta..-hydroxymyristic acid.
Authors:
Nerkar, D P; Govekar, L G; Kumta, U S; Sreenivasan, A [1] 
  1. Bhabha Atomic Research Centre, Bombay (India). Biochemistry and Food Technology Div.
Publication Date:
Sep 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-09-352018; EDB-78-051678
Resource Relation:
Journal Name: Int. J. Radiat. Biol.; (United Kingdom); Journal Volume: 32:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ENDOTOXINS; CHEMICAL RADIATION EFFECTS; LIPOPOLYSACCHARIDES; IN VIVO; MOLECULAR STRUCTURE; SALMONELLA TYPHIMURIUM; TETRADECANOIC ACID; TOXICITY; TOXOIDS; VACCINES; ANTIGENS; BACTERIA; CARBOHYDRATES; CARBOXYLIC ACIDS; CHEMISTRY; LIPIDS; MICROORGANISMS; MONOCARBOXYLIC ACIDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; POLYSACCHARIDES; RADIATION CHEMISTRY; RADIATION EFFECTS; SACCHARIDES; SALMONELLA; TOXIC MATERIALS; TOXINS; 560131* - Radiation Effects on Microorganisms- Basic Studies- (-1987)
OSTI ID:
5186381
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: IJRBA
Submitting Site:
INIS
Size:
Pages: 259-266
Announcement Date:

Citation Formats

Nerkar, D P, Govekar, L G, Kumta, U S, and Sreenivasan, A. Radiation induced alterations in the endotoxin of S. typhimurium. United Kingdom: N. p., 1977. Web. doi:10.1080/09553007714550971.
Nerkar, D P, Govekar, L G, Kumta, U S, & Sreenivasan, A. Radiation induced alterations in the endotoxin of S. typhimurium. United Kingdom. doi:10.1080/09553007714550971.
Nerkar, D P, Govekar, L G, Kumta, U S, and Sreenivasan, A. 1977. "Radiation induced alterations in the endotoxin of S. typhimurium." United Kingdom. doi:10.1080/09553007714550971. https://www.osti.gov/servlets/purl/10.1080/09553007714550971.
@misc{etde_5186381,
title = {Radiation induced alterations in the endotoxin of S. typhimurium}
author = {Nerkar, D P, Govekar, L G, Kumta, U S, and Sreenivasan, A}
abstractNote = {The lipopolysaccharide (LPS) of S. typhimurium has been shown to be significantly detoxified after in vivo irradiation at 500 krad. Radiation is thus a useful method for converting endotoxin into toxoid. The structural alterations in the detoxified LPS were shown to be mainly in the lipid A molecule, resulting in the loss of ..beta..-hydroxymyristic acid.}
doi = {10.1080/09553007714550971}
journal = {Int. J. Radiat. Biol.; (United Kingdom)}
volume = {32:3}
journal type = {AC}
place = {United Kingdom}
year = {1977}
month = {Sep}
}