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Myocardial myoglobin release after acute myocardial infarction

Journal Article:

Abstract

The magnitude and time course of myoglobin release from the myocardium following infarction was assessed by radioimmunoassay. The assay showed acceptable precision over a working range from 50 to 750 ng cm/sup -3/, provided careful control of the assay temperature was maintained. The use of this radioimmunoassay as an early diagnostic test for infarction and as a potential measure of the extent of necrosis is considered and comparison made with the release of CK-MB, the myocardial specific isoenzyme of creatine kinase. Of the twenty patients studied with myocardial infarction, all had elevated levels of serum myoglobin including those admitted within 3 hours of the onset of pain. In contrast, CK-MB was not detected in the serum within 5 hours of the onset of pain. Peak serum levels of myoglobin (mean 852 +- 365 ng cm/sup -3/) and CK-MB (mean 71 +- 25 mIU cm/sup -3/) were detected at 8-16 hours and 20-24 hours respectively after the onset of pain. A comparison of peak serum levels of myoglobin and CK-MB showed a good correlation (r = 0.84).
Authors:
Robinson, P S; Saltissi, S; Coltart, D J; Croft, D N [1] 
  1. Saint Thomas' Hospital, London (UK)
Publication Date:
Mar 01, 1980
Product Type:
Journal Article
Reference Number:
AIX-11-544345; EDB-80-103296
Resource Relation:
Journal Name: Nucl. Med. Commun.; (United Kingdom); Journal Volume: 1:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; MYOCARDIAL INFARCTION; DIAGNOSTIC TECHNIQUES; MYOGLOBIN; RADIOIMMUNOASSAY; ACCURACY; ANTIGEN-ANTIBODY REACTIONS; COMPARATIVE EVALUATIONS; CREATINE; IODINE 125; ISOENZYMES; LABELLED COMPOUNDS; MAN; AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CARDIOVASCULAR DISEASES; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; ENZYMES; GLOBIN; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PIGMENTS; PORPHYRINS; PRIMATES; PROTEINS; RADIOASSAY; RADIOISOTOPES; TRACER TECHNIQUES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550201 - Biochemistry- Tracer Techniques
OSTI ID:
5179964
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: NMCOD
Submitting Site:
INIS
Size:
Pages: 3-9
Announcement Date:

Journal Article:

Citation Formats

Robinson, P S, Saltissi, S, Coltart, D J, and Croft, D N. Myocardial myoglobin release after acute myocardial infarction. United Kingdom: N. p., 1980. Web.
Robinson, P S, Saltissi, S, Coltart, D J, & Croft, D N. Myocardial myoglobin release after acute myocardial infarction. United Kingdom.
Robinson, P S, Saltissi, S, Coltart, D J, and Croft, D N. 1980. "Myocardial myoglobin release after acute myocardial infarction." United Kingdom.
@misc{etde_5179964,
title = {Myocardial myoglobin release after acute myocardial infarction}
author = {Robinson, P S, Saltissi, S, Coltart, D J, and Croft, D N}
abstractNote = {The magnitude and time course of myoglobin release from the myocardium following infarction was assessed by radioimmunoassay. The assay showed acceptable precision over a working range from 50 to 750 ng cm/sup -3/, provided careful control of the assay temperature was maintained. The use of this radioimmunoassay as an early diagnostic test for infarction and as a potential measure of the extent of necrosis is considered and comparison made with the release of CK-MB, the myocardial specific isoenzyme of creatine kinase. Of the twenty patients studied with myocardial infarction, all had elevated levels of serum myoglobin including those admitted within 3 hours of the onset of pain. In contrast, CK-MB was not detected in the serum within 5 hours of the onset of pain. Peak serum levels of myoglobin (mean 852 +- 365 ng cm/sup -3/) and CK-MB (mean 71 +- 25 mIU cm/sup -3/) were detected at 8-16 hours and 20-24 hours respectively after the onset of pain. A comparison of peak serum levels of myoglobin and CK-MB showed a good correlation (r = 0.84).}
journal = {Nucl. Med. Commun.; (United Kingdom)}
volume = {1:1}
journal type = {AC}
place = {United Kingdom}
year = {1980}
month = {Mar}
}