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Epidemiology of diabetes mellitus in Japan

Technical Report:

Abstract

The clinical and epidemiological features of diabetes mellitus in Japan have been compiled and compared with data from other countries. Diabetes is basically the same in Japan as elsewhere: however, consideration of important differences has led to the following conclusions: The rarity of ketoacidosis in Japan is due to the mild carbohydrate defect present in most diabetics. The mild carbohydrate intolerance in diabetics is probably in part due to a high carbohydrate intake. Diabetic retinopathy is more common in women than in men in Japan; there are limited and conflicting data from the West on this point, but retinopathy, nephropathy and neuropathy occur about as frequently in Japan as in the West. Because of marked dietary differences between Japan and Western countries, these findings suggest that dietary fat has no significance in the pathogenesis of these lesions. Peripheral gangrene is distinctly unusual in Japanese diabetics. This suggests that either: the responsible vascular lesions are different from those responsible for nephropathy and retinopathy; or that small vessel lesions are the same but the lack of large vessel atherosclerosis in the population accounts for the decreased incidence of gangrene. Men have diabetes 2 or 3 times as commonly as women in Japan.  More>>
Publication Date:
Mar 12, 1964
Product Type:
Technical Report
Report Number:
ABCC-05-64
Reference Number:
EDB-84-057623
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; DIABETES MELLITUS; EPIDEMIOLOGY; A-BOMB SURVIVORS; COMPARATIVE EVALUATIONS; DATA COMPILATION; GLOBAL ASPECTS; HUMAN POPULATIONS; JAPAN; MORTALITY; PATHOGENESIS; SEX DEPENDENCE; ASIA; DATA; DISEASES; ENDOCRINE DISEASES; INFORMATION; METABOLIC DISEASES; NUMERICAL DATA; POPULATIONS; 550600* - Medicine
OSTI ID:
5176713
Research Organizations:
Atomic Bomb Casualty Commission, Hiroshima (Japan)
Country of Origin:
Japan
Language:
Japanese and English
Contract Number:
AC01-76EV03081
Other Identifying Numbers:
Other: ON: DE84008391
Availability:
NTIS, PC A02/MF A01.
Submitting Site:
HEDB
Size:
Pages: 24
Announcement Date:

Technical Report:

Citation Formats

Blackard, W G, Omori, Yoshiaki, and Freedman, L R. Epidemiology of diabetes mellitus in Japan. Japan: N. p., 1964. Web.
Blackard, W G, Omori, Yoshiaki, & Freedman, L R. Epidemiology of diabetes mellitus in Japan. Japan.
Blackard, W G, Omori, Yoshiaki, and Freedman, L R. 1964. "Epidemiology of diabetes mellitus in Japan." Japan.
@misc{etde_5176713,
title = {Epidemiology of diabetes mellitus in Japan}
author = {Blackard, W G, Omori, Yoshiaki, and Freedman, L R}
abstractNote = {The clinical and epidemiological features of diabetes mellitus in Japan have been compiled and compared with data from other countries. Diabetes is basically the same in Japan as elsewhere: however, consideration of important differences has led to the following conclusions: The rarity of ketoacidosis in Japan is due to the mild carbohydrate defect present in most diabetics. The mild carbohydrate intolerance in diabetics is probably in part due to a high carbohydrate intake. Diabetic retinopathy is more common in women than in men in Japan; there are limited and conflicting data from the West on this point, but retinopathy, nephropathy and neuropathy occur about as frequently in Japan as in the West. Because of marked dietary differences between Japan and Western countries, these findings suggest that dietary fat has no significance in the pathogenesis of these lesions. Peripheral gangrene is distinctly unusual in Japanese diabetics. This suggests that either: the responsible vascular lesions are different from those responsible for nephropathy and retinopathy; or that small vessel lesions are the same but the lack of large vessel atherosclerosis in the population accounts for the decreased incidence of gangrene. Men have diabetes 2 or 3 times as commonly as women in Japan. If sex-limited inheritance is discarded as a possible reason, it is likely that adult-onset diabetes is more common in men than women except in those countries (the West) where women gain relatively large amounts of weight. The rarity of juvenile diabetes in Japan is best explained by the infrequency of responsible genetic factors. As a consequence, it is likely that juvenile diabetes is caused by different or additional genetic factors which are not significant in adult-onset diabetes. Diabetes prevalance varies sufficiently between different localities in the same country to render the concept of national prevalance of doubtful usefulness. 55 references, 3 figures, 3 tables.}
place = {Japan}
year = {1964}
month = {Mar}
}