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Leukemia in Hiroshima atomic bomb survivors

Technical Report:

Abstract

This report is intended to provide the basic data pertinent to the leukemia experience observed in the survivors of the Hiroshima atomic explosion. Many of the conclusions in this report are tentative. The one clear fact to emerge is that radiation increases the occurrence rate of leukemia and that the magnitude of increase is dependent on dose received. Additional observations can be made, which, while not definitive in themselves, seem to complement each other, and are corroborated by other experiences in radiation biology. From the data a linear relationship between dose and incidence of leukemia is found. The shape of the relation in the lower dose range is not known with certainty. An approximate minimum time for the appearance of leukemia following radiation is 3 years or less. The data suggest that the time of maximum risk of leukemia may be dependent on the dose of radiation received. In this group the mean latent period is found to lie in the interval between 4 and 8 years following exposure. The length of time during which the increased incidence of leukemia persists is not known. The incidence of the acute leukemias and of chronic granulocytic leukemia is increased in the exposed  More>>
Publication Date:
Mar 01, 1959
Product Type:
Technical Report
Report Number:
ABCC-02-59
Reference Number:
EDB-84-057923
Resource Relation:
Other Information: Portions are illegible in microfiche products
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; A-BOMB SURVIVORS; LEUKEMIA; EPIDEMIOLOGY; ANEMIAS; DELAYED RADIATION EFFECTS; DOSE-RESPONSE RELATIONSHIPS; HEMIC DISEASES; HIROSHIMA; RADIATION HAZARDS; RADIOINDUCTION; ASIA; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; DISEASES; HAZARDS; HEALTH HAZARDS; HUMAN POPULATIONS; JAPAN; NEOPLASMS; POPULATIONS; RADIATION EFFECTS; SYMPTOMS; 560151* - Radiation Effects on Animals- Man; 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man
OSTI ID:
5175034
Research Organizations:
Atomic Bomb Casualty Commission, Hiroshima (Japan)
Country of Origin:
Japan
Language:
Japanese and English
Contract Number:
AC01-76EV03081
Other Identifying Numbers:
Other: ON: DE84008093
Availability:
NTIS, PC A04/MF A01; 1.
Submitting Site:
HEDB
Size:
Pages: 74
Announcement Date:

Technical Report:

Citation Formats

Heyssel, R, Brill, A B, Woodbury, L A, Nishimura, Edwin T, Ghose, Tarunendu, Hoshino, Takashi, and Yamasaki, Mitsuru. Leukemia in Hiroshima atomic bomb survivors. Japan: N. p., 1959. Web.
Heyssel, R, Brill, A B, Woodbury, L A, Nishimura, Edwin T, Ghose, Tarunendu, Hoshino, Takashi, & Yamasaki, Mitsuru. Leukemia in Hiroshima atomic bomb survivors. Japan.
Heyssel, R, Brill, A B, Woodbury, L A, Nishimura, Edwin T, Ghose, Tarunendu, Hoshino, Takashi, and Yamasaki, Mitsuru. 1959. "Leukemia in Hiroshima atomic bomb survivors." Japan.
@misc{etde_5175034,
title = {Leukemia in Hiroshima atomic bomb survivors}
author = {Heyssel, R, Brill, A B, Woodbury, L A, Nishimura, Edwin T, Ghose, Tarunendu, Hoshino, Takashi, and Yamasaki, Mitsuru}
abstractNote = {This report is intended to provide the basic data pertinent to the leukemia experience observed in the survivors of the Hiroshima atomic explosion. Many of the conclusions in this report are tentative. The one clear fact to emerge is that radiation increases the occurrence rate of leukemia and that the magnitude of increase is dependent on dose received. Additional observations can be made, which, while not definitive in themselves, seem to complement each other, and are corroborated by other experiences in radiation biology. From the data a linear relationship between dose and incidence of leukemia is found. The shape of the relation in the lower dose range is not known with certainty. An approximate minimum time for the appearance of leukemia following radiation is 3 years or less. The data suggest that the time of maximum risk of leukemia may be dependent on the dose of radiation received. In this group the mean latent period is found to lie in the interval between 4 and 8 years following exposure. The length of time during which the increased incidence of leukemia persists is not known. The incidence of the acute leukemias and of chronic granulocytic leukemia is increased in the exposed survivors. The chronic granulocytic variety is disproportionately increased in Japanese survivors of the atomic bomb. No effect of radiation on monocytic or chronic lymphatic leukemia incidence is noted. Aplastic anemia, polycythemia vera, and myelofibrosis have been investigated. Myelofibrosis is the only one of this group of diseases in which a suggestive relation to radiation exposure is apparent. The natural history of leukemia following radiation does not seem to differ from that of the spontaneously occurring variety. 17 references, 5 figures, 38 tables.}
place = {Japan}
year = {1959}
month = {Mar}
}