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Central nervous system in leukemia

Technical Report:

Abstract

The present report summarizes the pertinent clinical and pathologic findings in 165 cases of leukemia in atomic bomb exposed victims autopsied during the period 1949 to 1962 at ABCC in Hiroshima and Nagasaki, Japan. Significant parenchymal hemorrhage occurred most often in acute myelogenous leukemia and was markedly increased in patients dying with high terminal white blood cell counts. Possible mechanisms involved in the pathogenesis of cerebral hemorrhage in leukemia are discussed. Subarachnoid hemorrhage and subdural hematoma were not related to leukocytosis but appeared to be influenced by marked thrombocytopenia. Leukemic infiltrates of a diffuse nature involving the meninges were paradoxically increased in patients receiving adequate chemotherapy. Meningeal tumors did not show this peculiar relationship to therapy and were not found in association with lymphatic leukemia. Infections involving the central nervous system were confined to patients receiving chemotherapy including steroids. 39 references, 3 figures, 4 tables.
Publication Date:
Mar 12, 1964
Product Type:
Technical Report
Report Number:
ABCC-04-64
Reference Number:
EDB-84-057934
Resource Relation:
Other Information: Portions are illegible in microfiche products
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; A-BOMB SURVIVORS; AUTOPSY; LEUKEMIA; PATHOGENESIS; BRAIN; DELAYED RADIATION EFFECTS; HEMORRHAGE; HIROSHIMA; NAGASAKI; ASIA; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; HEMIC DISEASES; HUMAN POPULATIONS; JAPAN; NEOPLASMS; NERVOUS SYSTEM; ORGANS; PATHOLOGICAL CHANGES; POPULATIONS; RADIATION EFFECTS; SYMPTOMS; 560151* - Radiation Effects on Animals- Man; 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man
OSTI ID:
5174963
Research Organizations:
Atomic Bomb Casualty Commission, Hiroshima (Japan)
Country of Origin:
Japan
Language:
Japanese and English
Contract Number:
AC01-76EV03081
Other Identifying Numbers:
Other: ON: DE84008088
Availability:
NTIS, PC A03/MF A01; 1.
Submitting Site:
HEDB
Size:
Pages: 26
Announcement Date:
Apr 01, 1984

Technical Report:

Citation Formats

Phair, J P, Anderson, R E, and Namiki, Hideo. Central nervous system in leukemia. Japan: N. p., 1964. Web.
Phair, J P, Anderson, R E, & Namiki, Hideo. Central nervous system in leukemia. Japan.
Phair, J P, Anderson, R E, and Namiki, Hideo. 1964. "Central nervous system in leukemia." Japan.
@misc{etde_5174963,
title = {Central nervous system in leukemia}
author = {Phair, J P, Anderson, R E, and Namiki, Hideo}
abstractNote = {The present report summarizes the pertinent clinical and pathologic findings in 165 cases of leukemia in atomic bomb exposed victims autopsied during the period 1949 to 1962 at ABCC in Hiroshima and Nagasaki, Japan. Significant parenchymal hemorrhage occurred most often in acute myelogenous leukemia and was markedly increased in patients dying with high terminal white blood cell counts. Possible mechanisms involved in the pathogenesis of cerebral hemorrhage in leukemia are discussed. Subarachnoid hemorrhage and subdural hematoma were not related to leukocytosis but appeared to be influenced by marked thrombocytopenia. Leukemic infiltrates of a diffuse nature involving the meninges were paradoxically increased in patients receiving adequate chemotherapy. Meningeal tumors did not show this peculiar relationship to therapy and were not found in association with lymphatic leukemia. Infections involving the central nervous system were confined to patients receiving chemotherapy including steroids. 39 references, 3 figures, 4 tables.}
place = {Japan}
year = {1964}
month = {Mar}
}