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Binding of inorganic mercury by subcellular fractions and proteins of rat kidneys

Abstract

Inorganic mercury, administered to rats in a single dose of 0.5 mg Hg/kg is accumulated in the kidneys mainly in the soluble (54 percent) and nuclear (30 percent) fractions, showing decreasing tendency with time. Mitochondrial and microsomal fractions, initially accumulating approximately 11 and 6 percent of total Hg, show a tendency to increase the absolute level of Hg for the first week after administration. In the soluble fraction low-molecular weight, metallothioneinlike proteins are mainly responsible for the accumulation of mercury; in other fractions proteins of higher molecular weight prevail.
Publication Date:
Jan 01, 1976
Product Type:
Journal Article
Reference Number:
ERA-03-032160; EDB-78-061678
Resource Relation:
Journal Name: Arch. Toxikol.; (Germany, Federal Republic of); Journal Volume: 37:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MERCURY; BIOLOGICAL ACCUMULATION; ANIMAL CELLS; BIOCHEMICAL REACTION KINETICS; BIOLOGICAL EFFECTS; CELL NUCLEI; FRACTIONATION; KIDNEYS; MERCURY 203; MICROSOMES; MITOCHONDRIA; MOLECULAR WEIGHT; PROTEINS; RATS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CELL CONSTITUENTS; DAYS LIVING RADIOISOTOPES; ELEMENTS; EVEN-ODD NUCLEI; HEAVY NUCLEI; ISOTOPES; KINETICS; MAMMALS; MERCURY ISOTOPES; METALS; NUCLEI; ORGANIC COMPOUNDS; ORGANOIDS; ORGANS; RADIOISOTOPES; REACTION KINETICS; RODENTS; SEPARATION PROCESSES; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
5165171
Research Organizations:
Medical Adademy of Lodz, Poland
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ATXKA
Submitting Site:
TIC
Size:
Pages: 57-66
Announcement Date:
May 01, 1978

Citation Formats

Komsta-Szumska, E, Chmielnicka, J, and Piotrowski, J K. Binding of inorganic mercury by subcellular fractions and proteins of rat kidneys. Germany: N. p., 1976. Web.
Komsta-Szumska, E, Chmielnicka, J, & Piotrowski, J K. Binding of inorganic mercury by subcellular fractions and proteins of rat kidneys. Germany.
Komsta-Szumska, E, Chmielnicka, J, and Piotrowski, J K. 1976. "Binding of inorganic mercury by subcellular fractions and proteins of rat kidneys." Germany.
@misc{etde_5165171,
title = {Binding of inorganic mercury by subcellular fractions and proteins of rat kidneys}
author = {Komsta-Szumska, E, Chmielnicka, J, and Piotrowski, J K}
abstractNote = {Inorganic mercury, administered to rats in a single dose of 0.5 mg Hg/kg is accumulated in the kidneys mainly in the soluble (54 percent) and nuclear (30 percent) fractions, showing decreasing tendency with time. Mitochondrial and microsomal fractions, initially accumulating approximately 11 and 6 percent of total Hg, show a tendency to increase the absolute level of Hg for the first week after administration. In the soluble fraction low-molecular weight, metallothioneinlike proteins are mainly responsible for the accumulation of mercury; in other fractions proteins of higher molecular weight prevail.}
journal = []
volume = {37:1}
journal type = {AC}
place = {Germany}
year = {1976}
month = {Jan}
}