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Repair of pyrimidine dimers in radiation-sensitive mutants rad3, rad4, rad6, and rad9 of Saccharomyces cerevisiae. [nicking]

Journal Article:

Abstract

The ability to remove ultraviolet-induced pyrimidine dimers was examined in four radiation-sensitive mutants of Saccharomyces cerevisiae. The susceptibility of DNA from irradiated cells to nicking by either the T4 uv-endonuclease or an endonuclease activity found in crude extracts of Micrococcus luteus was used to measure the presence of dimers in DNA. The rad3 and rad4 mutants are shown to be defective in dimer excision whereas the rad6 and rad9 mutants are proficient in dimer excision.
Authors:
Prakash, L; [1]  Rochester Univ., N.Y. (USA). School of Medicine and Dentistry)
  1. Rochester Univ., N.Y. (USA). Dept. of Radiation Biology and Biophysics
Publication Date:
Oct 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-09-352019; EDB-78-051665
Resource Relation:
Journal Name: Mutat. Res.; (Netherlands); Journal Volume: 45:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DIMERS; BIOLOGICAL REPAIR; DNA; CHEMICAL RADIATION EFFECTS; MUTANTS; RADIOSENSITIVITY; PYRIMIDINES; SACCHAROMYCES CEREVISIAE; BIOASSAY; BIOCHEMICAL REACTION KINETICS; ULTRAVIOLET RADIATION; AZINES; BIOLOGICAL RECOVERY; BIOMASS; CHEMISTRY; ELECTROMAGNETIC RADIATION; ENERGY SOURCES; FUNGI; HETEROCYCLIC COMPOUNDS; KINETICS; MICROORGANISMS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PLANTS; RADIATION CHEMISTRY; RADIATION EFFECTS; RADIATIONS; REACTION KINETICS; RECOVERY; RENEWABLE ENERGY SOURCES; REPAIR; SACCHAROMYCES; YEASTS; 560112* - Radiation Effects on Biochemicals- In Microorganisms- (-1987); 560131 - Radiation Effects on Microorganisms- Basic Studies- (-1987)
OSTI ID:
5159478
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: MUREA
Submitting Site:
INIS
Size:
Pages: 13-20
Announcement Date:

Journal Article:

Citation Formats

Prakash, L, and Rochester Univ., N.Y. (USA). School of Medicine and Dentistry). Repair of pyrimidine dimers in radiation-sensitive mutants rad3, rad4, rad6, and rad9 of Saccharomyces cerevisiae. [nicking]. Netherlands: N. p., 1977. Web.
Prakash, L, & Rochester Univ., N.Y. (USA). School of Medicine and Dentistry). Repair of pyrimidine dimers in radiation-sensitive mutants rad3, rad4, rad6, and rad9 of Saccharomyces cerevisiae. [nicking]. Netherlands.
Prakash, L, and Rochester Univ., N.Y. (USA). School of Medicine and Dentistry). 1977. "Repair of pyrimidine dimers in radiation-sensitive mutants rad3, rad4, rad6, and rad9 of Saccharomyces cerevisiae. [nicking]." Netherlands.
@misc{etde_5159478,
title = {Repair of pyrimidine dimers in radiation-sensitive mutants rad3, rad4, rad6, and rad9 of Saccharomyces cerevisiae. [nicking]}
author = {Prakash, L, and Rochester Univ., N.Y. (USA). School of Medicine and Dentistry)}
abstractNote = {The ability to remove ultraviolet-induced pyrimidine dimers was examined in four radiation-sensitive mutants of Saccharomyces cerevisiae. The susceptibility of DNA from irradiated cells to nicking by either the T4 uv-endonuclease or an endonuclease activity found in crude extracts of Micrococcus luteus was used to measure the presence of dimers in DNA. The rad3 and rad4 mutants are shown to be defective in dimer excision whereas the rad6 and rad9 mutants are proficient in dimer excision.}
journal = {Mutat. Res.; (Netherlands)}
volume = {45:1}
journal type = {AC}
place = {Netherlands}
year = {1977}
month = {Oct}
}